scholarly journals Dissociation between CSD-Evoked Metabolic Perturbations and Meningeal Afferent Activation and Sensitization: Implications for Mechanisms of Migraine Headache Onset

2018 ◽  
Vol 38 (22) ◽  
pp. 5053-5066 ◽  
Author(s):  
Jun Zhao ◽  
Dan Levy
Keyword(s):  
Migraine Headache ◽  
Afferent Activation ◽  
Headache Onset

scholarly journals Weather, ambient air pollution, and risk of migraine headache onset among patients with migraine

2019 ◽  
Vol 132 ◽  
pp. 105100 ◽  
Author(s):  
Wenyuan Li ◽  
Suzanne M. Bertisch ◽  
Elizabeth Mostofsky ◽  
Catherine Buettner ◽  
Murray A. Mittleman
Keyword(s):  
Air Pollution ◽  
Migraine Headache ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Headache Onset

scholarly journals Dissociation between CSD-evoked metabolic perturbations and meningeal afferent activation and sensitization: implications for mechanisms of migraine headache onset

2017 ◽  
Author(s):  
Jun Zhao ◽  
Dan Levy
Keyword(s):  
Blood Flow ◽  
Migraine With Aura ◽  
Male Rats ◽  
Unit Recording ◽  
Cortical Blood Flow ◽  
Afferent Activation ◽  
Nociceptive Responses ◽  
Headache Onset ◽  
Meningeal Nociception ◽  
Large Vessels

AbstractThe onset of the headache phase during attacks of migraine with aura, which occur in about 30% of migraineurs, is believed to involve cortical spreading depression (CSD) and the ensuing activation and sensitization of primary afferent neurons that innervate the intracranial meninges, and their related large vessels. The mechanism by which CSD enhances the activity and mechanosensitivity of meningeal afferents remains poorly understood, but may involve cortical metabolic perturbations. We employed extracellular single-unit recording of meningeal afferent activity and monitored changes in cortical blood flow and tissue partial pressure of oxygen (tpO2) in anesthetized male rats to test whether the prolonged cortical hypoperfusion and reduction in tissue oxygenation that occur in the wake of CSD contribute to meningeal nociception. Suppression of CSD-evoked cortical hypoperfusion with the cyclooxygenase inhibitor naproxen blocked the reduction in cortical tpO2, but had no effect on the activation of meningeal afferents. Naproxen, however, distinctly prevented CSD-induced afferent mechanical sensitization. Counteracting the CSD-evoked persistent hypoperfusion and reduced tpO2 by preemptively increasing cortical blood flow using the K(ATP) channel opener levcromakalim did not inhibit the sensitization of meningeal afferents, but prevented their activation. Our data show that the cortical hypoperfusion and reduction in tpO2 that occur in the wake of CSD can be dissociated from the activation and mechanical sensitization of meningeal afferent responses suggesting that the metabolic changes do not contribute directly to these neuronal nociceptive responses.Significance statementCSD-evoked activation and mechanical sensitization of meningeal afferents is thought to mediate the headache phase in migraine with aura. We report that blocking the CSD-evoked cortical hypoperfusion and reduced tpO2 by cyclooxygenase inhibition is associated with the inhibition of the afferent sensitization but not their activation. Normalization of these CSD-evoked metabolic perturbations by activating K(ATP) channels is, however, associated with the inhibition of afferent activation but not sensitization. These results question the contribution of cortical metabolic perturbations to the triggering mechanism underlying meningeal nociception and the ensuing headache in migraine with aura, further point to distinct mechanisms underlying the activation and sensitization of meningeal afferents in migraine and highlight the need to target both processes for an effective migraine therapy.

scholarly journals Perimenstrual headache: Migraine without aura or premenstrual syndrome symptom?

2010 ◽  
Vol 67 (12) ◽  
pp. 969-976 ◽  
Author(s):  
Ana Sundic ◽  
Jasna Zidverc-Trajkovic ◽  
Svetlana Vujovic ◽  
Nadezda Sternic
Keyword(s):  
Premenstrual Syndrome ◽  
Migraine Headache ◽  
Migraine Without Aura ◽  
Tension Type Headache ◽  
Menstrual Migraine ◽  
Menstrually Related Migraine ◽  
Headache Onset ◽  
Perimenstrual Headache ◽  
Type Headache ◽  
Pure Menstrual Migraine

Background/Aim. Definition of menstrual migraine as a specific clinical entity or, maybe, migraine headache with menstrually related occurring, still remains unresolved question. The aim of this study was to investigate if perimenstrual headache in our patients fulfills diagnostic the International Classification of Headache Disorders (ICHD) criteria for migraine without aura or represents a different type of headache which is the symptom of premenstrual syndrome (PMS). Methods. The study included 50 women with headache in perimenstrual period in at least two out of three menstrual cycles, during the last year or longer. Two questionnaires, a questionnaire for headache and a questionnaire for PMS, were used. Results. The majority of all the examined women, 29 of them, had migraine and PMS and 9 women had migraine without PMS. Headache in 38 (76.0%) patients fulfilled diagnostic criteria for menstrual migraine, (26 and 12 women had pure menstrual migraine and menstrually related migraine respectively). Intensity of PMS was not different in a groups of women with different types of headache (p = 0.184): a total number of PMS symptoms was 8.2 ? 4.6 in the group with pure menstrual migraine, 10.8 ? 3.9 in the group with menstrually related migraine and 10.8 ? 6.3 in the group with non-migraine headache. Conclusion. This study shows that headache, occuring in perimenstrual period, is not always migraine, but could fulfill criteria for tension-type headache, as well. Specific characteristics of perimenstrual headache, which could distinguish it as a symptom of PMS, were not found. Expected relation in time of headache onset and menarche was not confirmed.

Episodic primary migraine headache: supplementary prophylaxis with Pycnogenol® prevents attacks and controls oxidative stress

2020 ◽  
Vol 62 (2) ◽  
Author(s):  
Maria R. Cesarone ◽  
Mark Dugall ◽  
Shu Hu ◽  
Gianni Belcaro ◽  
Morio Hosoi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Migraine Headache

Premorbid migraine history as a risk factor for vestibular and oculomotor baseline concussion assessment in pediatric athletes

2019 ◽  
Vol 23 (4) ◽  
pp. 465-470 ◽  
Author(s):  
Ryan N. Moran ◽  
Tracey Covassin ◽  
Jessica Wallace
Keyword(s):  
Risk Factor ◽  
Smooth Pursuit ◽  
Migraine Headache ◽  
Visual Motion ◽  
Assessment Tools ◽  
Motion Sensitivity ◽  
Ocular Reflex ◽  
Migraine Headaches ◽  
Vestibular Ocular Reflex ◽  
History Of

OBJECTIVEMigraine history has recently been identified as a risk factor for concussion and recovery. The authors performed a cross-sectional study examining baseline outcome measures on newly developed and implemented concussion assessment tools in pediatrics. The purpose of this study was to examine the effects of premorbid, diagnosed migraine headaches as a risk factor on vestibular and oculomotor baseline assessment in pediatric athletes.METHODSPediatric athletes between the ages of 8 and 14 years with a diagnosed history of migraine headache (n = 28) and matched controls without a history of diagnosed migraine headache (n = 28) were administered a baseline concussion assessment battery, consisting of the Vestibular/Ocular Motor Screening (VOMS), near point of convergence (NPC), and the King-Devick (K-D) tests. Between-groups comparisons were performed for vestibular symptoms and provocation scores on the VOMS (smooth pursuit, saccades, convergence, vestibular/ocular reflex, visual motion sensitivity), NPC (average distance), and K-D (time).RESULTSIndividuals diagnosed with migraine headaches reported greater VOMS smooth pursuit scores (p = 0.02), convergence scores (p = 0.04), vestibular ocular reflex scores (p value range 0.002–0.04), and visual motion sensitivity scores (p = 0.009). Differences were also observed on K-D oculomotor performance with worse times in those diagnosed with migraine headache (p = 0.02). No differences were reported on NPC distance (p = 0.06) or headache symptom reporting (p = 0.07) prior to the VOMS assessment.CONCLUSIONSPediatric athletes diagnosed with migraine headaches reported higher baseline symptom provocation scores on the VOMS. Athletes with migraine headaches also performed worse on the K-D test, further illustrating the influence of premorbid migraine headaches as a risk factor for elevated concussion assessment outcomes at baseline. Special consideration may be warranted for post-concussion assessment in athletes with migraine headaches.

The Feeding Network of Aplysia

2017 ◽  
pp. 400-422
Author(s):  
Elizabeth C. Cropper ◽  
Jian Jing ◽  
Klaudiusz R. Weiss
Keyword(s):  
Motor Activity ◽  
Task Switching ◽  
Neural Control ◽  
Modular Organization ◽  
Neural Basis ◽  
Distinctive Features ◽  
Afferent Activation ◽  
And Behaviors ◽  
And Behavior ◽  
Activation Phase

This review focuses on the neural control of feeding in Aplysia. Its purpose is to highlight distinctive features of the behavior and to describe their neural basis. In a number of molluscs, food is grasped by a radula that protracts, retracts, and hyperretracts. In Aplysia, however, hyperretraction can require afferent activation. Phase-dependent regulation of sensorimotor transmission occurs in this context. Aplysia also open and close the radula, generating egestive as well as ingestive responses. Thus, the feeding network multitasks. It has a modular organization, and behaviors are constructed by combinations of behavior-specific and behavior-independent neurons. When feeding is initially triggered in Aplysia, responses are poorly defined. Motor activity is not properly configured unless responses are repeatedly induced and modulatory neurotransmitters are released from inputs to the central patter generator (CPG). Persistent effects of modulation have interesting consequences for task switching.

Cerebral Circulatory Changes During Migraine Headache With Aura

1993 ◽  
Vol 4 (3) ◽  
Author(s):  
John Stirling Meyer ◽  
Yasuo Terayama ◽  
Shutaro Takashima ◽  
Katsuyuki Obara
Keyword(s):  
Migraine Headache
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