scholarly journals Temporal Patterns of Fos Expression in the Dentate Gyrus after Spontaneous Seizures in a Mouse Model of Temporal Lobe Epilepsy

2005 ◽  
Vol 25 (31) ◽  
pp. 7210-7220 ◽  
Author(s):  
Z. Peng
Keyword(s):  
Mouse Model ◽  
Temporal Lobe Epilepsy ◽  
Dentate Gyrus ◽  
Temporal Lobe ◽  
Temporal Patterns ◽  
Spontaneous Seizures ◽  
Fos Expression

scholarly journals Seizure frequency correlates with loss of dentate gyrus GABAergic neurons in a mouse model of temporal lobe epilepsy

2017 ◽  
Vol 525 (11) ◽  
pp. 2592-2610 ◽  
Author(s):  
Paul S. Buckmaster ◽  
Emily Abrams ◽  
Xiling Wen
Keyword(s):  
Mouse Model ◽  
Temporal Lobe Epilepsy ◽  
Dentate Gyrus ◽  
Temporal Lobe ◽  
Seizure Frequency ◽  
Gabaergic Neurons

scholarly journals Hilar somatostatin interneuron loss reduces dentate gyrus inhibition in a mouse model of temporal lobe epilepsy

Epilepsia ◽  
2016 ◽  
Vol 57 (6) ◽  
pp. 977-983 ◽  
Author(s):  
Gabrielle Hofmann ◽  
Laura Balgooyen ◽  
Joanna Mattis ◽  
Karl Deisseroth ◽  
Paul S. Buckmaster
Keyword(s):  
Mouse Model ◽  
Temporal Lobe Epilepsy ◽  
Dentate Gyrus ◽  
Temporal Lobe

Changes in Granule Cell Firing Rates Precede Locally Recorded Spontaneous Seizures by Minutes in an Animal Model of Temporal Lobe Epilepsy

2008 ◽  
Vol 99 (5) ◽  
pp. 2431-2442 ◽  
Author(s):  
Mark R. Bower ◽  
Paul S. Buckmaster
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Dentate Gyrus ◽  
Firing Rate ◽  
Temporal Lobe ◽  
Granule Cells ◽  
Neuronal Firing ◽  
Seizure Onset ◽  
Electrographic Seizure ◽  
Firing Rates ◽  
Spontaneous Seizures

Although much is known about persistent molecular, cellular, and circuit changes associated with temporal lobe epilepsy, mechanisms of seizure onset remain unclear. The dentate gyrus displays many persistent epilepsy-related abnormalities and is in the mesial temporal lobe where seizures initiate in patients. However, little is known about seizure-related activity of individual neurons in the dentate gyrus. We used tetrodes to record action potentials of multiple, single granule cells before and during spontaneous seizures in epileptic pilocarpine-treated rats. Subsets of granule cells displayed four distinct activity patterns: increased firing before seizure onset, decreased firing before seizure onset, increased firing only after seizure onset, and unchanged firing rates despite electrographic seizure activity in the immediate vicinity. No cells decreased firing rate immediately after seizure onset. During baseline periods between seizures, action potential waveforms and firing rates were similar among the four subsets of granule cells in epileptic rats and in granule cells of control rats. The mean normalized firing rate of granule cells whose firing rates increased before seizure onset deviated from baseline earliest, beginning 4 min before dentate gyrus electrographic seizure onset, and increased progressively, more than doubling by seizure onset. It is generally assumed that neuronal firing rates increase abruptly and synchronously only when electrographic seizures begin. However, these findings show heterogeneous and gradually building changes in activity of individual granule cells minutes before spontaneous seizures.

scholarly journals Dentate gyrus progenitor cell proliferation after the onset of spontaneous seizures in the tetanus toxin model of temporal lobe epilepsy

2013 ◽  
Vol 54 ◽  
pp. 492-498 ◽  
Author(s):  
Premysl Jiruska ◽  
Anan B.Y. Shtaya ◽  
David M.S. Bodansky ◽  
Wei-Chih Chang ◽  
William P. Gray ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Temporal Lobe Epilepsy ◽  
Dentate Gyrus ◽  
Temporal Lobe ◽  
Tetanus Toxin ◽  
Progenitor Cell ◽  
Spontaneous Seizures ◽  
Progenitor Cell Proliferation

scholarly journals Effects of TRPV1 activation on synaptic excitation in the dentate gyrus of a mouse model of temporal lobe epilepsy

2010 ◽  
Vol 223 (2) ◽  
pp. 529-536 ◽  
Author(s):  
Muthu D. Bhaskaran ◽  
Bret N. Smith
Keyword(s):  
Mouse Model ◽  
Temporal Lobe Epilepsy ◽  
Dentate Gyrus ◽  
Temporal Lobe ◽  
Synaptic Excitation

Naringenin ameliorates kainic acid-induced morphological alterations in the dentate gyrus in a mouse model of temporal lobe epilepsy

Neuroreport ◽  
2016 ◽  
Vol 27 (15) ◽  
pp. 1182-1189 ◽  
Author(s):  
Jungha Park ◽  
Kyoung Hoon Jeong ◽  
Won-Ho Shin ◽  
Young-Seuk Bae ◽  
Un Ju Jung ◽  
...  
Keyword(s):  
Mouse Model ◽  
Temporal Lobe Epilepsy ◽  
Dentate Gyrus ◽  
Kainic Acid ◽  
Temporal Lobe ◽  
Morphological Alterations

scholarly journals Preictal Activity of Subicular, CA1, and Dentate Gyrus Principal Neurons in the Dorsal Hippocampus before Spontaneous Seizures in a Rat Model of Temporal Lobe Epilepsy

2014 ◽  
Vol 34 (50) ◽  
pp. 16671-16687 ◽  
Author(s):  
S. Fujita ◽  
I. Toyoda ◽  
A. K. Thamattoor ◽  
P. S. Buckmaster
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Dentate Gyrus ◽  
Temporal Lobe ◽  
Rat Model ◽  
Dorsal Hippocampus ◽  
Spontaneous Seizures

Environmental enrichment reduces spontaneous seizures in the Q54 transgenic mouse model of temporal lobe epilepsy

Epilepsia ◽  
2011 ◽  
Vol 52 (9) ◽  
pp. e113-e117 ◽  
Author(s):  
Ilaria Manno ◽  
Francesca Macchi ◽  
Matteo Caleo ◽  
Yuri Bozzi
Keyword(s):  
Mouse Model ◽  
Temporal Lobe Epilepsy ◽  
Transgenic Mouse ◽  
Temporal Lobe ◽  
Environmental Enrichment ◽  
Transgenic Mouse Model ◽  
Spontaneous Seizures

Dentate gyrus and hilus transection blocks seizure propagation and granule cell dispersion in a mouse model for mesial temporal lobe epilepsy

Hippocampus ◽  
2011 ◽  
Vol 21 (3) ◽  
pp. 334-343 ◽  
Author(s):  
Johan Pallud ◽  
Ute Häussler ◽  
Mélanie Langlois ◽  
Sophie Hamelin ◽  
Bertrand Devaux ◽  
...  
Keyword(s):  
Mouse Model ◽  
Temporal Lobe Epilepsy ◽  
Dentate Gyrus ◽  
Temporal Lobe ◽  
Granule Cell ◽  
Mesial Temporal Lobe Epilepsy ◽  
Cell Dispersion ◽  
Mesial Temporal Lobe ◽  
Seizure Propagation
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