Metabotropic Glutamate Receptor 5 Upregulation in A-Fibers after Spinal Nerve Injury: 2-Methyl-6-(Phenylethynyl)-Pyridine (MPEP) Reverses the Induced Thermal Hyperalgesia

Lindsey J. Hudson; Stuart Bevan; Kara McNair; Clive Gentry; Alyson Fox; Rainer Kuhn; Janet Winter

doi:10.1523/jneurosci.22-07-02660.2002

Metabotropic Glutamate Receptor 5 Upregulation in A-Fibers after Spinal Nerve Injury: 2-Methyl-6-(Phenylethynyl)-Pyridine (MPEP) Reverses the Induced Thermal Hyperalgesia

Journal of Neuroscience ◽

10.1523/jneurosci.22-07-02660.2002 ◽

2002 ◽

Vol 22 (7) ◽

pp. 2660-2668 ◽

Cited By ~ 76

Author(s):

Lindsey J. Hudson ◽

Stuart Bevan ◽

Kara McNair ◽

Clive Gentry ◽

Alyson Fox ◽

...

Keyword(s):

Nerve Injury ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Thermal Hyperalgesia ◽

Spinal Nerve ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

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Publisher Correction: Upregulation of prefrontal metabotropic glutamate receptor 5 mediates neuropathic pain and negative mood symptoms after spinal nerve injury in rats

Scientific Reports ◽

10.1038/s41598-018-26993-2 ◽

2018 ◽

Vol 8 (1) ◽

Author(s):

Geehoon Chung ◽

Chae Young Kim ◽

Yeong-Chan Yun ◽

Sang Ho Yoon ◽

Myoung-Hwan Kim ◽

...

Keyword(s):

Neuropathic Pain ◽

Nerve Injury ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Negative Mood ◽

Spinal Nerve ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Mood Symptoms

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Publisher Correction: Upregulation of prefrontal metabotropic glutamate receptor 5 mediates neuropathic pain and negative mood symptoms after spinal nerve injury in rats

Scientific Reports ◽

10.1038/s41598-018-19727-x ◽

2018 ◽

Vol 8 (1) ◽

Author(s):

Geehoon Chung ◽

Chae Young Kim ◽

Yeong-Chan Yun ◽

Sang Ho Yoon ◽

Myoung-Hwan Kim ◽

...

Keyword(s):

Neuropathic Pain ◽

Nerve Injury ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Negative Mood ◽

Spinal Nerve ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Mood Symptoms

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Prostaglandin and Protein Kinase A-Dependent Modulation of Vanilloid Receptor Function by Metabotropic Glutamate Receptor 5: Potential Mechanism for Thermal Hyperalgesia

Journal of Neuroscience ◽

10.1523/jneurosci.22-17-07444.2002 ◽

2002 ◽

Vol 22 (17) ◽

pp. 7444-7452 ◽

Cited By ~ 128

Author(s):

Hui-Juan Hu ◽

Gautam Bhave ◽

Robert W. Gereau

Keyword(s):

Protein Kinase ◽

Protein Kinase A ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Thermal Hyperalgesia ◽

Potential Mechanism ◽

Receptor Function ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Kinase A

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The Effects of MPEP, a Selective Metabotropic Glutamate Receptor 5 Antagonist, on Conditioned Taste Aversion in Rats

PsycEXTRA Dataset ◽

10.1037/e413812005-369 ◽

2002 ◽

Author(s):

Todd R. Schachtman ◽

Carla Bills ◽

Rodica Ghinescu ◽

Kevin Murch ◽

Agnes Simonyi

Keyword(s):

Taste Aversion ◽

Glutamate Receptor ◽

Conditioned Taste Aversion ◽

Metabotropic Glutamate Receptor ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

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Faculty Opinions recommendation of Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718499023.793498248 ◽

2014 ◽

Author(s):

Roland Seifert

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Transmembrane Domain ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Class C

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Faculty Opinions recommendation of Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu5) X-ray Structures.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.732704940.793543297 ◽

2018 ◽

Author(s):

Dario Doller

Keyword(s):

G Protein ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulators ◽

G Protein Coupled Receptor ◽

Metabotropic Glutamate Receptor 5 ◽

X Ray ◽

Metabotropic Glutamate ◽

G Protein Coupled

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Downregulation of metabotropic glutamate receptor 5 alleviates central sensitization by activating autophagy via inhibiting mTOR pathway in a rat model of chronic migraine

Neuroscience Letters ◽

10.1016/j.neulet.2020.135552 ◽

2021 ◽

Vol 743 ◽

pp. 135552

Author(s):

Yingying Niu ◽

Xiaoxu Zeng ◽

Guangcheng Qin ◽

Dunke Zhang ◽

Jiying Zhou ◽

...

Keyword(s):

Chronic Migraine ◽

Glutamate Receptor ◽

Rat Model ◽

Central Sensitization ◽

Metabotropic Glutamate Receptor ◽

Mtor Pathway ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

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Allosteric enhancement of metabotropic glutamate receptor 5 function promotes spatial memory

Neuroscience ◽

10.1016/j.neuroscience.2006.06.043 ◽

2006 ◽

Vol 142 (3) ◽

pp. 691-702 ◽

Cited By ~ 67

Author(s):

D. Balschun ◽

W. Zuschratter ◽

W. Wetzel

Keyword(s):

Spatial Memory ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

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Opposite regulation of metabotropic glutamate receptor 3 and metabotropic glutamate receptor 5 by inflammatory stimuli in cultured microglia and astrocytes

Neuroscience ◽

10.1016/j.neuroscience.2011.12.044 ◽

2012 ◽

Vol 205 ◽

pp. 29-38 ◽

Cited By ~ 26

Author(s):

J.V. Berger ◽

A.O. Dumont ◽

M.C. Focant ◽

M. Vergouts ◽

A. Sternotte ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Metabotropic Glutamate Receptor 3 ◽

Inflammatory Stimuli

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Chronic corticosterone administration down-regulates metabotropic glutamate receptor 5 protein expression in the rat hippocampus

Neuroscience ◽

10.1016/j.neuroscience.2010.06.023 ◽

2010 ◽

Vol 169 (4) ◽

pp. 1567-1574 ◽

Cited By ~ 25

Author(s):

A.H. Iyo ◽

A.M. Feyissa ◽

A. Chandran ◽

M.C. Austin ◽

S. Regunathan ◽

...

Keyword(s):

Protein Expression ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Rat Hippocampus ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate

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