scholarly journals Neuroprotective Role of a Brain-Enriched Tyrosine Phosphatase, STEP, in Focal Cerebral Ischemia

2013 ◽  
Vol 33 (45) ◽  
pp. 17814-17826 ◽  
Author(s):  
I. Deb ◽  
N. Manhas ◽  
R. Poddar ◽  
S. Rajagopal ◽  
A. M. Allan ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Tyrosine Phosphatase

scholarly journals The regulatory role of NF-κB in autophagy-like cell death after focal cerebral ischemia in mice

Neuroscience ◽  
2013 ◽  
Vol 244 ◽  
pp. 16-30 ◽  
Author(s):  
W.-L. Li ◽  
S.P. Yu ◽  
D. Chen ◽  
S.S. Yu ◽  
Y.-J. Jiang ◽  
...  
Keyword(s):  
Cell Death ◽  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Regulatory Role

scholarly journals Retraction notice to “The role of ASIC1a in neuroprotection elicited by quercetin in focal cerebral ischemia” [Brain Res. Vol. 1383 (2011) 289–299]

2022 ◽  
Vol 1775 ◽  
pp. 147729
Author(s):  
Anand Kumar Pandey ◽  
Puja Panwar Hazari ◽  
Ranjana Patnaik ◽  
Anil Kumar Mishra
Keyword(s):  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Retraction Notice

scholarly journals Dual Role of Fcγ Receptor in Transient Focal Cerebral Ischemia in Mice

Stroke ◽  
2004 ◽  
Vol 35 (4) ◽  
pp. 958-963 ◽  
Author(s):  
Miki Komine-Kobayashi ◽  
Nei Chou ◽  
Hideki Mochizuki ◽  
Atsuhito Nakao ◽  
Yoshikuni Mizuno ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Dual Role ◽  
Fcγ Receptor ◽  
Transient Focal Cerebral Ischemia

scholarly journals Role of rno-miR-124-3p in regulating MCT1 expression in rat brain after permanent focal cerebral ischemia

2019 ◽  
Vol 6 (4) ◽  
pp. 398-406 ◽  
Author(s):  
Shi-ye Xu ◽  
Xu-li Jiang ◽  
Qian Liu ◽  
Jin Xu ◽  
Juan Huang ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Rat Brain ◽  
Focal Cerebral Ischemia

scholarly journals Neuroprotective Role of Transgenic PAF-Acetylhydrolase II in Mouse Models of Focal Cerebral Ischemia

Stroke ◽  
2007 ◽  
Vol 38 (3) ◽  
pp. 1063-1068 ◽  
Author(s):  
Kimiko Umemura ◽  
Ichiro Kato ◽  
Yutaka Hirashima ◽  
Yoko Ishii ◽  
Takao Inoue ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Mouse Models ◽  
Focal Cerebral Ischemia ◽  
Paf Acetylhydrolase

scholarly journals Angiopoietin-2 is Vasoprotective in the Acute Phase of Cerebral Ischemia

2012 ◽  
Vol 33 (3) ◽  
pp. 389-395 ◽  
Author(s):  
Léna Marteau ◽  
Samuel Valable ◽  
Didier Divoux ◽  
Simon A Roussel ◽  
Omar Touzani ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Acute Phase ◽  
Focal Cerebral Ischemia ◽  
Neurovascular Unit ◽  
Protective Role ◽  
Lesion Volume ◽  
Ischemic Lesion ◽  
Vessel Growth ◽  
Angiopoietin 2

Most forms of cerebral ischemia are characterized by damage to the entire neurovascular unit, which leads to an increase in the permeability of the blood–brain barrier (BBB). In response to permanent focal cerebral ischemia in mice, we detected an early concomitant increase in the expression of the vascular endothelial growth factor (VEGF), a key inducer of vascular leakage and pathological blood vessel growth, and of angiopoietin-2 (Ang2), which is closely associated with VEGF in vascular remodeling. Thus, the aim of this study was to evaluate the role of Ang2 alone, or in combination with VEGF, in the acute phase of cerebral ischemia. The effect of these angiogenic factors on the ischemic lesion volume was evaluated by magnetic resonance imaging. We observed that timely administration of VEGF exacerbates ischemic damage. In contrast, Ang2 decreases the ischemic volume and this beneficial effect is maintained in the presence of VEGF. This investigation reports, for the first time, a protective role of Ang2 following cerebral ischemia, an action associated with a reduced BBB permeability. We propose that Ang2 represents a pertinent molecular target for the treatment of cerebral ischemia since acute brain damage may be limited by a pharmacological protection of the vascular compartment.

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