scholarly journals Cerebellar Cortex and Cerebellar Nuclei Are Concomitantly Activated during Eyeblink Conditioning: A 7T fMRI Study in Humans

2015 ◽  
Vol 35 (3) ◽  
pp. 1228-1239 ◽  
Author(s):  
M. Thurling ◽  
F. Kahl ◽  
S. Maderwald ◽  
R. M. Stefanescu ◽  
M. Schlamann ◽  
...  
Keyword(s):  
Cerebellar Cortex ◽  
Eyeblink Conditioning ◽  
Cerebellar Nuclei ◽  
Fmri Study ◽  
7T Fmri

Involvement of the cerebellar cortex and nuclei in verbal and visuospatial working memory: A 7T fMRI study

NeuroImage ◽  
2012 ◽  
Vol 62 (3) ◽  
pp. 1537-1550 ◽  
Author(s):  
M. Thürling ◽  
H. Hautzel ◽  
M. Küper ◽  
M.R. Stefanescu ◽  
S. Maderwald ◽  
...  
Keyword(s):  
Working Memory ◽  
Cerebellar Cortex ◽  
Visuospatial Working Memory ◽  
Fmri Study ◽  
7T Fmri

scholarly journals Activation of the cerebellar cortex and the dentate nucleus in a prism adaptation fMRI study

2013 ◽  
Vol 35 (4) ◽  
pp. 1574-1586 ◽  
Author(s):  
Michael Küper ◽  
Meret J.S. Wünnemann ◽  
Markus Thürling ◽  
Roxana M. Stefanescu ◽  
Stefan Maderwald ◽  
...  
Keyword(s):  
Cerebellar Cortex ◽  
Dentate Nucleus ◽  
Prism Adaptation ◽  
Fmri Study

scholarly journals Changes in membrane properties of rat deep cerebellar nuclear projection neurons during acquisition of eyeblink conditioning

2018 ◽  
Vol 115 (40) ◽  
pp. E9419-E9428 ◽  
Author(s):  
Desheng Wang ◽  
Carrie A. Smith-Bell ◽  
Lauren B. Burhans ◽  
Deidre E. O’Dell ◽  
Roger W. Bell ◽  
...  
Keyword(s):  
Pseudorabies Virus ◽  
Eyeblink Conditioning ◽  
Cerebellar Nuclei ◽  
Membrane Properties ◽  
Projection Neurons ◽  
Adult Rats ◽  
Electrophysiological Properties ◽  
Conditioned Responses ◽  
Sensory Nervous System ◽  
Whole Cell Recordings

Previous studies have shown changes in membrane properties of neurons in rat deep cerebellar nuclei (DCN) as a function of development, but due to technical difficulties in obtaining viable DCN slices from adult animals, it remains unclear whether there are learning-related alterations in the membrane properties of DCN neurons in adult rats. This study was designed to record from identified DCN cells in cerebellar slices from postnatal day 25–26 (P25–26) rats that had a relatively mature sensory nervous system and were able to acquire learning as a result of tone–shock eyeblink conditioning (EBC) and to document resulting changes in electrophysiological properties. After electromyographic electrode implantation at P21 and inoculation with a fluorescent pseudorabies virus (PRV-152) at P22–23, rats received either four sessions of paired delay EBC or unpaired stimulus presentations with a tone conditioned stimulus and a shock unconditioned stimulus or sat in the training chamber without stimulus presentations. Compared with rats given unpaired stimuli or no stimulus presentations, rats given paired EBC showed an increase in conditioned responses across sessions. Whole-cell recordings of both fluorescent and nonfluorescent DCN projection neurons showed that delay EBC induced significant changes in membrane properties of evoked DCN action potentials including a reduced after-hyperpolarization amplitude and shortened latency. Similar findings were obtained in hyperpolarization-induced rebound spikes of DCN neurons. In sum, delay EBC produced significant changes in the membrane properties of juvenile rat DCN projection neurons. These learning-specific changes in DCN excitability have not previously been reported in any species or task.

Cerebellar Grafts Partially Reverse Amino Acid Receptor Changes Observed in the Cerebellum of Mice with Hereditary Ataxia: Quantitative Autoradiographic Studies

1997 ◽  
Vol 6 (3) ◽  
pp. 347-359
Author(s):  
Kalliope Stasi ◽  
Adamantia Mitsacos ◽  
Lazaros C. Triarhou ◽  
Elias D. Kouvelas
Keyword(s):  
Nmda Receptors ◽  
Cerebellar Cortex ◽  
Binding Sites ◽  
Molecular Layer ◽  
Cerebellar Nuclei ◽  
Granule Cell Layer ◽  
Wild Type ◽  
Hereditary Ataxia ◽  
Deep Cerebellar Nuclei ◽  
Muscimol Binding

We used quantitative autoradiography of [3H]CNQX (200 nM), [3H]muscimol (13 nM), and [3H]flunitrazepam (10 nM) binding to study the distribution of non-NMDA and GABAA receptors in the cerebellum of pcd mutant mice with unilateral cerebellar grafts. Nonspecific binding was determined by incubation with 1 mM Glu, 200 μM GABA, or 1 μM clonazepam, respectively. Saturation parameters were defined in wild-type and mutant cerebella. In mutants, non-NMDA receptors were reduced by 38% in the molecular layer and by 47% in the granule cell layer. The reduction of non-NMDA receptors in the pcd cerebellar cortex supports their localization on Purkinje cells. [3H] CNQX binding sites were visualized at higher density in grafts that had migrated to the cerebellar cortex of the hosts (4.1 and 11.0 pmol/mg protein, respectively, at 23 and 37 days after grafting) than in grafts arrested intraparen-chymally (2.6 and 6.2 pmol/mg protein, respectively, at 23 and 37 days after grafting). The pattern of expression of non-NMDA receptors in cortical vs. parenchymal grafts suggests a possible regulation of their levels by transacting elements from host parallel fibers. GABAA binding levels in the grafts for both ligands used were similar to normal molecular layer. Binding was increased in the deep cerebellar nuclei of pcd mutants: the increase in [3H]muscimol binding over normal was 215% and the increase in [3H]flunitrazepam binding was 89%. Such increases in the pcd deep cerebellar nuclei may reflect a denervation-induced supersensitivity subsequent to the loss of Purkinje axon terminal innervation. In the deep nuclei of pcd mutants with unilateral cerebellar grafts, [3H]muscimol binding was 31% lower in the grafted side than in the contralateral nongrafted side at 37 days after transplantation; [3H]fluni-trazepam binding was also lower in the grafted side by 15% compared to the nongrafted side. Such changes in GABAA receptors suggest a significant, albeit partial, normalizing trend of cerebellar grafts on the state of postsynaptic supersensitive receptors in the host cerebellar nuclei.

scholarly journals Hippocampal functional connectivity in Alzheimer’s disease: a resting state 7T fMRI study

2020 ◽  
pp. 1-2 ◽  
Author(s):  
Latha Velayudhan ◽  
Susan Francis ◽  
Richard Dury ◽  
Subhadip Paul ◽  
Sana Bestwn ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Connectivity ◽  
Resting State ◽  
Fmri Study ◽  
7T Fmri
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