scholarly journals Role of Fabp7, a Downstream Gene of Pax6, in the Maintenance of Neuroepithelial Cells during Early Embryonic Development of the Rat Cortex

2005 ◽  
Vol 25 (42) ◽  
pp. 9752-9761 ◽  
Author(s):  
Y. Arai
Keyword(s):  
Embryonic Development ◽  
Early Embryonic Development ◽  
Rat Cortex ◽  
Neuroepithelial Cells

scholarly journals Functional role of AKT signaling in bovine early embryonic development: potential link to embryotrophic actions of follistatin

2018 ◽  
Vol 16 (1) ◽  
Author(s):  
Mohamed Ashry ◽  
Sandeep K. Rajput ◽  
Joseph K. Folger ◽  
Jason G. Knott ◽  
Nabil A. Hemeida ◽  
...  
Keyword(s):  
Embryonic Development ◽  
Functional Role ◽  
Akt Signaling ◽  
Early Embryonic Development ◽  
Development Potential ◽  
Potential Link

scholarly journals The role of apoptosis in early embryonic development of the adenohypophysis in rats

2008 ◽  
Vol 4 (1) ◽  
Author(s):  
Jens Weingärtner ◽  
Kristina Lotz ◽  
Andreas Faltermeier ◽  
Oliver Driemel ◽  
Johannes Kleinheinz ◽  
...  
Keyword(s):  
Embryonic Development ◽  
Early Embryonic Development

scholarly journals Role of bone morphogenetic protein signaling in bovine early embryonic development and stage specific embryotropic actions of follistatin†

2020 ◽  
Vol 102 (4) ◽  
pp. 795-805 ◽  
Author(s):  
Sandeep K Rajput ◽  
Chunyan Yang ◽  
Mohamed Ashry ◽  
Joseph K Folger ◽  
Jason G Knott ◽  
...  
Keyword(s):  
Embryonic Development ◽  
Bone Morphogenetic Proteins ◽  
Mammalian Species ◽  
Cell Lineage ◽  
Bmp Signaling ◽  
Early Embryonic Development ◽  
Protein Signaling ◽  
Bovine Embryos ◽  
Embryonic Genome

Abstract Characterization of the molecular factors regulating early embryonic development and their functional mechanisms is critical for understanding the causes of early pregnancy loss in monotocous species (cattle, human). We previously characterized a stage specific functional role of follistatin, a TGF-beta superfamily binding protein, in promoting early embryonic development in cattle. The mechanism by which follistatin mediates this embryotropic effect is not precisely known as follistatin actions in cattle embryos are independent of its classically known activin inhibition activity. Apart from activin, follistatin is known to bind and modulate the activity of the bone morphogenetic proteins (BMPs), which signal through SMAD1/5 pathway and regulate several aspects of early embryogenesis in other mammalian species. Present study was designed to characterize the activity and functional requirement of BMP signaling during bovine early embryonic development and to investigate if follistatin involves BMP signaling for its stage specific embryotropic actions. Immunostaining and western blot analysis demonstrated that SMAD1/5 signaling is activated after embryonic genome activation in bovine embryos. However, days 1–3 follistatin treatment reduced the abundance of phosphorylated SMAD1/5 in cultured embryos. Inhibition of active SMAD1/5 signaling (8–16 cell to blastocyst) using pharmacological inhibitors and/or lentiviral-mediated inhibitory SMAD6 overexpression showed that SMAD1/5 signaling is required for blastocyst production, first cell lineage determination as well as mRNA and protein regulation of TE (CDX2) cell markers. SMAD1/5 signaling was also found to be essential for embryotropic actions of follistatin during days 4–7 but not days 1–3 of embryo development suggesting a role for follistatin in regulation of SMAD1/5 signaling in bovine embryos.

scholarly journals Role of PAFAH1B1 in human spermatogenesis, fertilization and early embryonic development

2015 ◽  
Vol 31 (5) ◽  
pp. 613-624 ◽  
Author(s):  
Gui-Dong Yao ◽  
Sen-Lin Shi ◽  
Wen-Yan Song ◽  
Hai-Xia Jin ◽  
Zhao-Feng Peng ◽  
...  
Keyword(s):  
Embryonic Development ◽  
Early Embryonic Development ◽  
Human Spermatogenesis

scholarly journals Role of Importin Alpha8, a New Member of the Importin Alpha Family of Nuclear Transport Proteins, in Early Embryonic Development in Cattle1

2009 ◽  
Vol 81 (2) ◽  
pp. 333-342 ◽  
Author(s):  
Jyothsna Tejomurtula ◽  
Kyung-Bon Lee ◽  
Swamy K. Tripurani ◽  
George W. Smith ◽  
Jianbo Yao
Keyword(s):  
Embryonic Development ◽  
Nuclear Transport ◽  
Transport Proteins ◽  
Early Embryonic Development ◽  
Importin Alpha

scholarly journals Potential role of intermedin/adrenomedullin 2 in early embryonic development in rats

2011 ◽  
Vol 170 (1-3) ◽  
pp. 65-71 ◽  
Author(s):  
Madhu Chauhan ◽  
Rebekah Elkins ◽  
Meena Balakrishnan ◽  
Chandra Yallampalli
Keyword(s):  
Embryonic Development ◽  
Potential Role ◽  
Early Embryonic Development
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