Re-Envisioning the History of Cellular and Molecular Biology

2021 ◽  
Vol 51 (5) ◽  
pp. 642-654
Author(s):  
Andrew S. Reynolds
Keyword(s):  
Molecular Biology ◽  
History Of

History of Biochemistry and Molecular Biology

Science ◽  
1970 ◽  
Vol 170 (3955) ◽  
pp. 349-351 ◽  
Author(s):  
J. T. Edsall
Keyword(s):  
Molecular Biology ◽  
History Of

scholarly journals DNA Tumor Viruses and Their Contributions to Molecular Biology

2019 ◽  
Vol 93 (9) ◽  
Author(s):  
James M. Pipas
Keyword(s):  
Molecular Biology ◽  
Cancer Biology ◽  
Tumor Viruses ◽  
The World ◽  
Tumor Virus ◽  
History Of ◽  
The Impact

ABSTRACTThis summer marks the 51st anniversary of the DNA tumor virus meetings. Scientists from around the world will gather in Trieste, Italy, to report their latest results and to agree or disagree on the current concepts that define our understanding of this diverse class of viruses. This article offers a brief history of the impact the study of these viruses has had on molecular and cancer biology and discusses obstacles and opportunities for future progress.

A History of Molecular Biology. Michel Morange , Matthew Cobb

2000 ◽  
Vol 75 (3) ◽  
pp. 303-303
Author(s):  
Nathaniel Comfort
Keyword(s):  
Molecular Biology ◽  
History Of

scholarly journals The Sociological Debate of the Life Sciences Research: from Molecular Biology to Human Genome Sequencing

2017 ◽  
Vol 5 (1) ◽  
pp. 53
Author(s):  
Renan Goncalves Leonel Da Silva ◽  
Maria Conceicao Da Costa
Keyword(s):  
Molecular Biology ◽  
Social Studies ◽  
Information And Communication Technology ◽  
Communication Technology ◽  
Life Sciences ◽  
Social Studies Of Science ◽  
Information And Communication ◽  
Human Genome Sequencing ◽  
History Of ◽  
Post War

This paper presents some sociological debates involved in the new field of life sciences at the end of 20th century. From a bibliographic review concerning history of science and Social Studies of Science, it will be presented some particular sociological issues of the research on molecular biology and its historical evolution – the formation of speeches and legitimization; institutional arrangements and alliances in post-war period. We will focuses on the emerging systems of information and communication technology, ICTs. and how it transformed the biomedical research. The goal is to show briefly how molecular biology was built, from the post-war period to the end of the 90’s, and what was the main proceedings of interdisciplinary associations and technoscientific interactions in the life sciences agenda.

scholarly journals Beijerinck's work on tobacco mosaic virus: historical context and legacy

1999 ◽  
Vol 354 (1383) ◽  
pp. 675-685 ◽  
Author(s):  
L. Bos
Keyword(s):  
Molecular Biology ◽  
Tobacco Mosaic Virus ◽  
Mosaic Virus ◽  
Close Association ◽  
Historical Context ◽  
True Nature ◽  
Animal Virus ◽  
Virus Particles ◽  
Contagious Diseases ◽  
History Of

Beijerinck's entirely new concept, launched in 1898, of a filterable contagium vivum fluidum which multiplied in close association with the host's metabolism and was distributed in phloem vessels together with plant nutrients, did not match the then prevailing bacteriological germ theory. At the time, tools and concepts to handle such a new kind of agent (the viruses) were non–existent. Beijerinck's novel idea, therefore, did not revolutionize biological science or immediately alter human understanding of contagious diseases. That is how bacteriological dogma persisted, as voiced by Loeffler and Frosch when showing the filterability of an animal virus (1898), and especially by Ivanovsky who had already in 1892 detected filterability of the agent of tobacco mosaic but kept looking for a microbe and finally (1903) claimed its multiplication in an artificial medium. The dogma was also strongly advocated by Roux in 1903, when writing the first review on viruses, which he named ‘so–called “invisible” microbes’, unwittingly including the agent of bovine pleuropneumonia, only much later proved to be caused by a mycoplasma. In 1904, Baur was the first to advocate strongly the chemical view of viruses. But uncertainty about the true nature of viruses, with their similarities to enzymes and genes, continued until the 1930s when at long last tobacco mosaic virus particles were isolated as an enzyme–like protein (1935), soon to be better characterized as a nucleoprotein (1937). Physicochemical virus studies were a key element in triggering molecular biology which was to provide further means to reveal the true nature of viruses ‘at the threshold of life’. Beijerinck's 1898 vision was not appreciated or verified during his lifetime. But Beijerinck already had a clear notion of the mechanism behind the phenomena he observed. Developments in virology and molecular biology since 1935 indicate how close Beijerinck (and even Mayer, Beijerinck's predecessor in research on tobacco mosaic) had been to the mark. The history of research on tobacco mosaic and the commitments of Mayer, Beijerinck and others demonstrate that progress in science is not only a matter of mere technology but of philosophy as well. Raemaekers' Mayer cartoon, inspired by Beijerinck, artistically represents the crucial question about the reliability of our images of reality, and about the scope of our technological interference with nature.

scholarly journals Novel Therapies in Glioblastoma

2012 ◽  
Vol 2012 ◽  
pp. 1-14 ◽  
Author(s):  
James Perry ◽  
Masahiko Okamoto ◽  
Michael Guiou ◽  
Katsuyuki Shirai ◽  
Allison Errett ◽  
...  
Keyword(s):  
Natural History ◽  
Molecular Biology ◽  
Targeted Therapies ◽  
Conventional Treatment ◽  
Tumor Biology ◽  
Treatment Resistance ◽  
Novel Therapies ◽  
History Of Disease ◽  
History Of ◽  
Poor Outcomes

Conventional treatment of glioblastoma has advanced only incrementally in the last 30 years and still yields poor outcomes. The current strategy of surgery, radiation, and chemotherapy has increased median survival to approximately 15 months. With the advent of molecular biology and consequent improved understanding of basic tumor biology, targeted therapies have become cornerstones for cancer treatment. Many pathways (RTKs, PI3K/AKT/mTOR, angiogenesis, etc.) have been identified in GBM as playing major roles in tumorigenesis, treatment resistance, or natural history of disease. Despite the growing understanding of the complex networks regulating GBM tumors, many targeted therapies have fallen short of expectations. In this paper, we will discuss novel therapies and the successes and failures that have occurred. One clear message is that monotherapies yield minor results, likely due to functionally redundant pathways. A better understanding of underlying tumor biology may yield insights into optimal targeting strategies which could improve the overall therapeutic ratio of conventional treatments.

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