Ang2 inhibitors and Tie2 activators: potential therapeutics in perioperative treatment of early stage cancer

AbstractPlatelets have an important role in tumor angiogenesis, growth, and metastasis. The reciprocal interaction between cancer and platelets results in changes of several platelet characteristics. It is becoming clear that analysis of these platelet features could offer a new strategy in the search for biomarkers of cancer. Here, we review the human studies in which platelet characteristics (e.g., count, volume, protein, and mRNA content) are investigated in early-stage cancer. The main focus of this paper is to evaluate which platelet features are suitable for the development of a blood test that could detect cancer in its early stages.

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Simple and fast isolation of circulating exosomes with chitosan modified shuttle flow microchip towards breast cancer diagnosis

Lab on a Chip ◽

10.1039/d0lc01311k ◽

2021 ◽

Author(s):

Wenwen Chen ◽

Rongkai Cao ◽

Wentao Su ◽

xu zhang ◽

Yuhai Xu ◽

...

Keyword(s):

Breast Cancer ◽

Medical Treatment ◽

Cancer Diagnosis ◽

Biological Samples ◽

Early Stage ◽

Breast Cancer Diagnosis ◽

Early Stage Cancer ◽

Tumor Prognosis ◽

Huge Challenge

Tumor-derived exosomes have been recognized as promising biomarkers for early-stage cancer diagnosis, tumor prognosis monitoring and individual medical treatment. However, separating exosomes from trace biological samples is a huge challenge...

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Genetic clues can be used to predict whether early-stage cancer will form an invasive tumour

Nature ◽

10.1038/d41586-019-00567-2 ◽

2019 ◽

Vol 566 (7744) ◽

pp. 336-337

Author(s):

Heidi Greulich ◽

Andrew D. Cherniack

Keyword(s):

Early Stage ◽

Early Stage Cancer ◽

Invasive Tumour

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Inorganic nanoparticles for the theranostics of cancer

European Journal of Nanomedicine ◽

10.1515/ejnm-2015-0024 ◽

2015 ◽

Vol 7 (4) ◽

Cited By ~ 6

Author(s):

Jyoti Verma ◽

Sumit Lal ◽

Cornelis J.F. Van Noorden

Keyword(s):

Cancer Cells ◽

Patient Survival ◽

Early Stage ◽

Cancer Diagnostics ◽

Inorganic Nanoparticles ◽

Hybrid Nanoparticles ◽

Early Stage Cancer ◽

Organic Shell ◽

Clinical Advances

AbstractTheranostics are a multifunctional approach using nanoparticles for combined diagnostic and therapeutic purposes. The hybrid nanoparticles that are applied for these purposes are composed of an inorganic core and an organic shell. The inorganic core acts as a contrast enhancer and the organic shell acts as a drug releaser. Hybrid nanoparticles can be conjugated with targeting moieties and systematically administered to patients to direct the nanoparticles to specific cells such as cancer cells. Theranostics have the potential to significantly improve early stage cancer diagnostics and patient survival. This review discusses preclinical and clinical advances in applications of inorganic nanoparticles for the theranostics of cancer.

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