EXTRAPOLATION OF THE VISUAL SCENE IN THE DESIGN OF INTERIOR SPACES

The current research deals with the study of extrapolating the visual scene in the design of internal spaces on the grounds that design is a language whose context must be understood in order to access the meanings and connotations through its design symbols in order to extrapolate that visual scene. Extrapolation of the visual landscape in the design of interior spaces)? Therefore, the aim was to reveal the role of extrapolating the visual scene in the design of spaces, and the first chapter included the importance of research, the need for it and its terminology, while the second chapter included a detail of the theoretical framework on which we relied and which consisted of two studies, and through these investigations indicators were reached for the theoretical framework that pour In the topic of the research, which helped in arriving at the method of research methodology adopted in the third chapter, which included the research procedures, while the fourth chapter included a review of the results, the most prominent of which was that there is a relatively verified expression of the identity of space as requirements in extrapolating the visual scene of the first model. The function of the design visual scene was related to a reciprocal interaction between the function of space and the identity of the place, to accommodate extrapolation according to the nature of its priorities that acquire the appropriate space form.

Home in question: Uncovering meanings, desires and dilemmas of non-home

What is the opposite of home? Is it necessarily something ‘negative’? Similar questions, far from having a self-evident answer, make for a fruitful entry point for research into the social experience of home. Central to this article is a novel conceptualization of non-home, against the background of the pre-existing criticisms of the normative, romanticized and depoliticized understandings of home. This article draws from fieldwork on the everyday dwelling experience of migrants and asylum seekers to illustrate the volitional dimension of non-home. Not attaching a sense of home to a dwelling place or set of relationships is not merely a consequence of poor housing conditions. It may also involve an active choice – at least at some points of the life course, in certain household conditions. In this sense, non-home is more than a matter of absence, dispossession, reconfiguration or implosion of home. In questioning the normative view of home as inherently positive and desirable, this conceptualization highlights the reciprocal interaction between home and non-home as mutually interdependent constructs.

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability

SIRT6 is an NAD+-dependent deacetylase that plays an important role in mitosis fidelity and genome stability. In the present study, we found that SIRT6 overexpression leads to mitosis defects and aneuploidy. We identified SIRT6 as a novel substrate of anaphase-promoting complex/cyclosome (APC/C), which is a master regulator of mitosis. Both CDH1 and CDC20, co-activators of APC/C, mediated SIRT6 degradation via the ubiquitination-proteasome pathway. Reciprocally, SIRT6 also deacetylated CDH1 at lysine K135 and promoted its degradation, resulting in an increase in APC/C-CDH1-targeted substrates, dysfunction in centrosome amplification, and chromosome instability. Our findings demonstrate the importance of SIRT6 for genome integrity during mitotic progression and reveal how SIRT6 and APC/C cooperate to drive mitosis.