scholarly journals Platelets as messengers of early-stage cancer

2021 ◽  
Author(s):  
Siamack Sabrkhany ◽  
Marijke J. E. Kuijpers ◽  
Mirjam G. A. oude Egbrink ◽  
Arjan W. Griffioen
Keyword(s):  
Tumor Angiogenesis ◽  
Blood Test ◽  
Early Stage ◽  
Human Studies ◽  
Early Stage Cancer ◽  
Reciprocal Interaction ◽  
Early Stages ◽  
New Strategy ◽  
Mrna Content

AbstractPlatelets have an important role in tumor angiogenesis, growth, and metastasis. The reciprocal interaction between cancer and platelets results in changes of several platelet characteristics. It is becoming clear that analysis of these platelet features could offer a new strategy in the search for biomarkers of cancer. Here, we review the human studies in which platelet characteristics (e.g., count, volume, protein, and mRNA content) are investigated in early-stage cancer. The main focus of this paper is to evaluate which platelet features are suitable for the development of a blood test that could detect cancer in its early stages.

Blood test for early-stage cancer

Science ◽  
2017 ◽  
Vol 358 (6360) ◽  
pp. 184.3-184
Author(s):  
Priscilla N. Kelly
Keyword(s):  
Blood Test ◽  
Early Stage ◽  
Early Stage Cancer

Gold Nanoparticle-Enabled Blood Test for Early Stage Cancer Detection and Risk Assessment

2015 ◽  
Vol 7 (12) ◽  
pp. 6819-6827 ◽  
Author(s):  
Tianyu Zheng ◽  
Nickisha Pierre-Pierre ◽  
Xin Yan ◽  
Qun Huo ◽  
Alvin J.O. Almodovar ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Gold Nanoparticle ◽  
Cancer Detection ◽  
Blood Test ◽  
Early Stage ◽  
Early Stage Cancer

Simple and fast isolation of circulating exosomes with chitosan modified shuttle flow microchip towards breast cancer diagnosis

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Wenwen Chen ◽  
Rongkai Cao ◽  
Wentao Su ◽  
xu zhang ◽  
Yuhai Xu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Medical Treatment ◽  
Cancer Diagnosis ◽  
Biological Samples ◽  
Early Stage ◽  
Breast Cancer Diagnosis ◽  
Early Stage Cancer ◽  
Tumor Prognosis ◽  
Huge Challenge

Tumor-derived exosomes have been recognized as promising biomarkers for early-stage cancer diagnosis, tumor prognosis monitoring and individual medical treatment. However, separating exosomes from trace biological samples is a huge challenge...

scholarly journals The expression of microRNA-331-3p and microRNA-23b3 in Egyptian patients with early-stage hepatocellular carcinoma in hepatitis C-related liver cirrhosis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Reham A. Aboelwafa ◽  
Walid Ismail Ellakany ◽  
Marwa A. Gamaleldin ◽  
Marwa A. Saad
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Hepatitis C ◽  
Early Stage ◽  
Group Iii ◽  
Real Time Quantitative Pcr ◽  
Early Stages ◽  
Group I ◽  
Egyptian Patients ◽  
Cirrhotic Patients

Abstract Background Hepatocellular carcinoma and hepatitis C are strongly associated. The current work aimed to study the expression levels of microRNA-331-3p and microRNA-23b-3p as propable biomarkers for detecting liver cancer (HCC) at its early stages in patients with HCV-related liver cirrhosis. The current prospective study included two hundred participants, divided into three groups: group I, 100 patients with HCV-related liver cirrhosis; group II, 50 HCC patients at early stages; and group III, 50 apparentlyhealthy controls. All patients had routine laboratory workup and ultrasound hepatic assessment. Values of microRNA-331-3p and microRNA-23b-3p were measured by real-time quantitative PCR. Results Levels of miR-331-3p were significantly higher in HCC patients than in cirrhotic patients and controls (p < 0.001), while levels of miR-23b-3p were significantly lower in HCC patients compared to cirrhotics and controls (p < 0.001). ROC curve revealed that miR-23b-3p had 80% sensitivity and 74% specificity, miR-331-3p had 66% sensitivity and 61% specificity, and AFP had 64% sensitivity and 61% specificity of 61% in discrimination between HCC patients from controls. Conclusion Serum miR-23b-3p is a more effective predictor than miR-331-3p and AFP for the development of hepatocellular carcinoma in hepatitis C (HCV)-related cirrhotic patients.

scholarly journals Genetic clues can be used to predict whether early-stage cancer will form an invasive tumour

Nature ◽  
2019 ◽  
Vol 566 (7744) ◽  
pp. 336-337
Author(s):  
Heidi Greulich ◽  
Andrew D. Cherniack
Keyword(s):  
Early Stage ◽  
Early Stage Cancer ◽  
Invasive Tumour

Inorganic nanoparticles for the theranostics of cancer

2015 ◽  
Vol 7 (4) ◽  
Author(s):  
Jyoti Verma ◽  
Sumit Lal ◽  
Cornelis J.F. Van Noorden
Keyword(s):  
Cancer Cells ◽  
Patient Survival ◽  
Early Stage ◽  
Cancer Diagnostics ◽  
Inorganic Nanoparticles ◽  
Hybrid Nanoparticles ◽  
Early Stage Cancer ◽  
Organic Shell ◽  
Clinical Advances

AbstractTheranostics are a multifunctional approach using nanoparticles for combined diagnostic and therapeutic purposes. The hybrid nanoparticles that are applied for these purposes are composed of an inorganic core and an organic shell. The inorganic core acts as a contrast enhancer and the organic shell acts as a drug releaser. Hybrid nanoparticles can be conjugated with targeting moieties and systematically administered to patients to direct the nanoparticles to specific cells such as cancer cells. Theranostics have the potential to significantly improve early stage cancer diagnostics and patient survival. This review discusses preclinical and clinical advances in applications of inorganic nanoparticles for the theranostics of cancer.

scholarly journals A combination of platelet features allows detection of early-stage cancer

2017 ◽  
Vol 80 ◽  
pp. 5-13 ◽  
Author(s):  
Siamack Sabrkhany ◽  
Marijke J.E. Kuijpers ◽  
Sander M.J. van Kuijk ◽  
Linda Sanders ◽  
Sharo Pineda ◽  
...  
Keyword(s):  
Early Stage ◽  
Early Stage Cancer
Sign in / Sign up

Export Citation Format

Share Document