Peculiarities of indexes of autonomic regulation of blood circulation and heart rate variability in perimenopausal women

Abstract Funding Acknowledgements Type of funding sources: None. Main funding source(s): North-Western State Medical University named after I.I. Mechnikov Objective to study the features of autonomic regulation of sinus rhythm features of autonomic regulation of cardiac sinus rhythm in patients with Takotsubo syndrome (TTS) during inpatient stay in hospital. Materials and methods. The study included 25 female patients (the median age 57.5 ± 28.5 years) with TTS, diagnosis was based on the InterTAK criteria. On the 5-7th day after admission, the heart rate variability (HRV) was assessed both at rest and cardiac autonomic function tests: the deep breathing test (DBT) and active orthostatic test (AOT) with the usage of a computer diagnostic system «Valenta». RESULTS According to HRV data, initially at rest, the majority of the studied patients predominantly had a parasympathetic impact on the heart rate regulation: in 70% - increased parasympathetic influence, in 17% - increased sympathetic influence, in 13% - a balanced heart rate regulation. When performing a DBT, the predominance of the parasympathetic influence on the heart rate was noted both in spectral parameters and according to the data of time analysis (HF during DBT increased 1.8 times up to 489.6 ± 114.2 ms2 (p <0.05) ; LF decreased 1.7 times up to 254.1 ± 70.3 ms2 (p <0.05); VLF increased 2.8 times up to 402.3 ± 101.8 ms2 (p <0, 05); TP increased 1.4 times up to 1145.9 ± 251.3 ms2; CV increased 1.3 times up to 6.5 ± 0.7% (p <0.05); SDNN increased 1.3 times up to - 58.7 ± 6.6 ms (p <0.05). HRV measured during an AOT showed a paradoxical evaluation in the parasympathetic impact on the heart rate (HF increased by 1.8 times and reached - 488.0 ± 104.7 ms2 (p <0.05); LF decreased by 1.1 times up to 408 , 4 ± 103.6 ms2; VLF increased 1.2 times up to 166.4 ± 52.2 ms2; TP increased 1.3 times up to 1062.8 ± 181.1 ms2 (p <0.05); CV increased 1.6 times up to 8.0 ± 0.9% (p <0.05); SDNN increased 1.4 times up to 62.6 ± 7.5 ms (p <0.05)). Conclusions During the index hospital inpatient stays the majority of patients with TTS have a vegetative imbalance due to increased parasympathetic influence on the heart rate, both at rest and during a deep breathing test and an active orthostatic test. This fact is quite unexpected and requires further study.

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HEART RATE VARIABILITY AND DISPERSION MAPPING OF ECG IN MAGADAN REGION PREINDUCTEES WITH VAGOTONIC TYPE OF AUTONOMIC REGULATION

Human Ecology ◽

10.33396/1728-0869-2018-7-36-42 ◽

2018 ◽

pp. 36-42

Author(s):

A. N. Loskutova ◽

A. L. Maksimov

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Autonomic Regulation ◽

Magadan Region

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HRV as predicting the outcome of acute stroke

Bulletin of Siberian Medicine ◽

10.20538/1682-0363-2008-5-2-444-447 ◽

2008 ◽

Vol 7 (5-2) ◽

pp. 444-447

Author(s):

I. M. Utochkina ◽

Yu. S. Shamurov ◽

V. A. Mironov

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Spectral Analysis ◽

Ischemic Stroke ◽

Acute Stroke ◽

Hemorrhagic Stroke ◽

Fatal Outcome ◽

Autonomic Regulation

To study the peculiarities of parameters autonomic regulation at various types of stroke in the acutest and after the acute stroke periods, and also the degrees of their influence on the forecast at stroke are appreciated results of the spectral analysis of heart rate variability in patients with hemorrhagic stroke and ischemic stroke. The indexes of heart rate variability for patients with a fatal outcome are exposed.

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Effect of fingolimod on cardiac autonomic regulation in patients with multiple sclerosis

Multiple Sclerosis Journal ◽

10.1177/1352458515604384 ◽

2015 ◽

Vol 22 (8) ◽

pp. 1080-1085 ◽

Cited By ~ 14

Author(s):

Sakari Simula ◽

Tomi Laitinen ◽

Tiina M Laitinen ◽

Tuula Tarkiainen ◽

Päivi Hartikainen ◽

...

Keyword(s):

Multiple Sclerosis ◽

Heart Rate ◽

Heart Rate Variability ◽

High Frequency ◽

Frequency Ratio ◽

Low Frequency ◽

Autonomic Regulation ◽

Rr Interval ◽

Cardiac Autonomic Regulation ◽

Multiple Sclerosis Patients

Background: Fingolimod modulates sphingosine-1-phosphate receptors that are also found in cardiovascular tissue. Objective: To investigate the effects of fingolimod on cardiac autonomic regulation prospectively. Methods: Twenty-seven relapsing–remitting multiple sclerosis patients underwent 24-hour electrocardiogram recording before, at the first day of fingolimod treatment (1d) and after three months of continuous dosing (3mo). The time interval between two consecutive R-peaks (RR-interval) was measured. Cardiac autonomic regulation was assessed by the various parameters of heart rate variability. Parasympathetic stimulation prolongs the RR-interval and increases heart rate variability while the effects of sympathetic stimulation are mainly the opposite. The low frequency/high frequency ratio reflects sympathovagal balance. Results: From baseline to 1d, a prolongation of the RR-interval ( P<0.001), an increase in the values of various heart rate variability parameters ( P<0.05 to P<0.001) and a decrease in the low frequency/high frequency ratio ( P<0.05) were demonstrated. At 3mo, although the RR-interval remained longer ( P<0.01), the values of various heart rate variability parameters were lower ( P<0.01 to P<0.001) as compared to baseline. At 3mo, the low frequency/high frequency ratio ( P<0.05) was higher in men than in women although no such difference was found at baseline or at 1d. Conclusions: After an initial increase in parasympathetic regulation, continuous fingolimod dosing shifts cardiac autonomic regulation towards sympathetic predominance, especially in men. Careful follow-up of fingolimod-treated relapsing–remitting multiple sclerosis patients is warranted as sympathetic predominance associates generally with impaired outcome. ClinicalTrials.cov: NCT01704183

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Binary symbolic dynamics analysis to detect stress-associated changes of nonstationary heart rate variability

Scientific Reports ◽

10.1038/s41598-020-72034-2 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Conrad Spellenberg ◽

Peter Heusser ◽

Arndt Büssing ◽

Andreas Savelsbergh ◽

Dirk Cysarz

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Psychological Stress ◽

Symbolic Dynamics ◽

Acute Stress ◽

Stress Test ◽

Autonomic Regulation ◽

Rr Interval ◽

Cardiac Autonomic Regulation ◽

Acute Psychological Stress

Abstract Psychological stress may have harmful physiological effects and result in deteriorating health. Acute psychological stress acts also on cardiac autonomic regulation and may lead to nonstationarities in the interbeat interval series. We address the requirement of stationary RR interval series to calculate frequency domain parameters of heart rate variability (HRV) and use binary symbolic dynamics derived from RR interval differences to overcome this obstacle. 24 healthy subjects (12 female, 20–35 years) completed the following procedure: waiting period, Trier Social Stress Test to induce acute psychological stress, recovery period. An electrocardiogram was recorded throughout the procedure and HRV parameters were calculated for nine 5-min periods. Nonstationarities in RR interval series were present in all periods. During acute stress the average RR interval and SDNN decreased compared to rest before and after the stress test. Neither low frequency oscillations (LF), high frequency oscillations (HF) nor LF/HF could unambiguously reflect changes during acute stress in comparison to rest. Pattern categories derived from binary symbolic dynamics clearly identified acute stress and accompanying alterations of cardiac autonomic regulation. Methods based on RR interval differences like binary symbolic dynamics should be preferred to overcome issues related to nonstationarities.

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