Lymph Node Involvement and Related Risk Factors in Patients With Breast Cancer Referred for Radiotherapy: A 20-Year Study on 15000 Women

Objectives: Tumor size and axillary lymph node (LN) involvement are used as prognostic markers and a guide for choosing adjuvant therapy. This study aimed to evaluate LN involvement and related risk factors in patients with breast cancer (BC) referred for radiotherapy. Materials and Methods: Using the census sampling method, 15,000 women with BC referring for radiotherapy were enrolled in this retrospective descriptive study performed at Tabriz University of Medical Sciences during 2000-2020. LN involvement and related risk factors were recorded and analyzed using the t test and ANOVA test at a significance level of P<0.05. Results: The prevalence of LN involvement in this study was 25%. The estrogen receptor status and LN involvement were associated with metastasis. The odds ratio of metastasis in patients with a negative estrogen receptor was about twice that of women with estrogen receptor positivity. Finally, the risk of metastasis in patients presenting with LN involvement was eight times higher than that of patients without LN involvement. Conclusion: In general, estrogen receptor status and LN involvement were associated with metastasis in patients with BC. Thus, these factors can be regarded as a guide to start necessary interventions earlier in at-risk patients.

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Breast Cancer and Ethnicity: Strong Association between Reproductive Risk Factors and Estrogen Receptor Status in Asian Patients?A Retrospective Study

The Breast Journal ◽

10.1111/j.1524-4741.2007.00442.x ◽

2007 ◽

Vol 13 (4) ◽

pp. 352-358 ◽

Cited By ~ 4

Author(s):

Tehillah S. Menes ◽

Junko Ozao ◽

Unsup Kim

Keyword(s):

Breast Cancer ◽

Risk Factors ◽

Estrogen Receptor ◽

Retrospective Study ◽

Estrogen Receptor Status ◽

Strong Association ◽

Reproductive Risk ◽

Receptor Status ◽

Asian Patients ◽

Reproductive Risk Factors

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Risk factors according to estrogen receptor status of breast cancer patients in Trivandrum, South India

International Journal of Cancer ◽

10.1002/ijc.24460 ◽

2009 ◽

Vol 125 (7) ◽

pp. 1663-1670 ◽

Cited By ~ 32

Author(s):

Subhojit Dey ◽

Paolo Boffetta ◽

Anitha Mathews ◽

Paul Brennan ◽

Amr Soliman ◽

...

Keyword(s):

Breast Cancer ◽

Risk Factors ◽

Estrogen Receptor ◽

Cancer Patients ◽

South India ◽

Estrogen Receptor Status ◽

Breast Cancer Patients ◽

Receptor Status

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Association of Interactions Between Mammographic Density Phenotypes and Established Risk Factors With Breast Cancer Risk, by Tumor Subtype and Menopausal Status

American Journal of Epidemiology ◽

10.1093/aje/kwaa131 ◽

2020 ◽

Vol 190 (1) ◽

pp. 44-58

Author(s):

Hongjie Chen ◽

Lusine Yaghjyan ◽

Christopher Li ◽

Ulrike Peters ◽

Bernard Rosner ◽

...

Keyword(s):

Breast Cancer ◽

Risk Factors ◽

Estrogen Receptor ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Mammographic Density ◽

Estrogen Receptor Status ◽

Health Study ◽

Receptor Status ◽

Dense Tissue

Abstract Previous studies suggest that the association between mammographic density (MD) and breast cancer risk might be modified by other breast cancer risk factors. In this study, we assessed multiplicative interactions between MD measures and established risk factors on the risk of invasive breast cancer overall and according to menopausal and estrogen receptor status. We used data on 2,137 cases and 4,346 controls from a nested case-control study within the Nurses’ Health Study (1976–2004) and Nurses’ Health Study II (1989–2007), whose data on percent mammographic density (PMD) and absolute area of dense tissue and nondense tissue (NDA) were available. No interaction remained statistically significant after adjusting for number of comparisons. For breast cancer overall, we observed nominally significant interactions (P < 0.05) between nulliparity and PMD/NDA, age at menarche and area of dense tissue, and body mass index and NDA. Individual nominally significant interactions across MD measures and risk factors were also observed in analyses stratified by either menopausal or estrogen receptor status. Our findings help provide further insights into potential mechanisms underlying the association between MD and breast cancer.

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