scholarly journals Do We Need Alternative Screening Approaches for Cervical Cancer During Covid-19 Pandemic?

2021 ◽  
Vol 9 (4) ◽  
pp. 228-229
Author(s):  
Mertihan Kurdoğlu ◽  
Arash Khaki
Keyword(s):  
Cervical Cancer ◽  
Screening Approaches

scholarly journals Evidence-Based, Alternative Cervical Cancer Screening Approaches in Low-Resource Settings

2009 ◽  
Vol 35 (03) ◽  
pp. 147-154 ◽  
Author(s):  
Jacqueline Sherris ◽  
Scott Wittet ◽  
Amy Kleine ◽  
John Sellors ◽  
Silvana Luciani ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Cervical Cancer Screening ◽  
Evidence Based ◽  
Low Resource Settings ◽  
Low Resource ◽  
Screening Approaches

scholarly journals Different cervical cancer screening approaches in a Chinese multicentre study

2009 ◽  
Vol 100 (3) ◽  
pp. 532-537 ◽  
Author(s):  
N Li ◽  
J-F Shi ◽  
S Franceschi ◽  
W-H Zhang ◽  
M Dai ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Multicentre Study ◽  
Cervical Cancer Screening ◽  
Screening Approaches

Cervical cancer prevention for all the world's women: Genuine promise resides in skilled quality management rather than novel screening approaches

2007 ◽  
Vol 35 (3) ◽  
pp. 187-191 ◽  
Author(s):  
Eric J. Suba ◽  
Amber D. Donnelly ◽  
Lisa M. Furia ◽  
My Linh D. Huynh ◽  
Stephen S. Raab ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Quality Management ◽  
Cancer Prevention ◽  
Cervical Cancer Prevention ◽  
Screening Approaches

scholarly journals Challenges of false positive and negative results in cervical cancer screening

2020 ◽  
Author(s):  
David Robert Grimes ◽  
Edward M.A. Corry ◽  
Talía Malagón ◽  
Ciaran O’Riain ◽  
Eduardo L. Franco ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Predictive Value ◽  
False Positive ◽  
Hpv Vaccination ◽  
Life Time ◽  
Hpv Infection ◽  
Vaccination Rates ◽  
The Cost ◽  
Screening Approaches

ABSTRACTObjectiveTo quantify the impact and accuracy of different screening approaches for cervical cancer, including liquid based cytology (LBC), molecular testing for human papillomavirus (HPV) infection, and their combinations via parallel co-testing and sequential triage. The secondary goal was to predict the effect of differing coverage rates of HPV vaccination on the performance of screening tests and in the interpretation of their results.DesignModelling study.Main outcomes measuredDifferent screening modalities were compared in terms of number of cases of Cervical intra-epithelial neoplasia (CIN) grade 2 and 3 detected and missed, as well as the number of false positives leading to excess colposcopy, and number of tests required to achieve a given level of accuracy. The positive predictive value (PPV) and negative predictive value (NPV) of different modalities were simulated under varying levels of HPV vaccination.ResultsThe model predicted that in a typical population, primary LBC screening misses 4.9 (95% Confidence Interval (CI) 3.5-CIN 2 / 3 cases per 1000 women, and results in 95 (95% CI: 93-97%) false positives leading to excess colposcopy. For primary HPV testing, 2.0 (95% CI: 1.9-2.1) cases were missed per 1000 women, with 99 (95% CI: 98-101) excess colposcopies undertaken. Co-testing markedly reduced missed cases to 0.5 (95% CI: 0.3-0.7) per 1000 women, but at the cost of dramatically increasing excess colposcopy referral to 184 per 1000 women (95% CI: 182-188). Conversely, triage testing with reflex screening substantially reduced excess colposcopy to 9.6 cases per 1000 women (95% CI: 9.3 - 10) but at the cost of missing more cases (6.4 per 1000 women, 95% CI: 5.1 - 8.0). Over a life-time of screening, women who always attend annual and 3-year co-testing were predicted to have a virtually 100% chance of falsely detecting a CIN 2 / 3 case, while 5 year co-testing has a 93.8% chance of a false positive over screening life-time. For annual, 3 year, and 5 year triage testing (either LBC with HPV reflex or vice versa), lifetime risk of a false positive is 35.1%, 13.4%, and 8.3% respectively. HPV vaccination rates adversely impact the PPV, while increasing the NPV of various screening modalities. Results of this work indicate that as HPV vaccination rates increase, HPV based screening approaches result in fewer unnecessary colposcopies than LBC approaches.ConclusionThe clinical relevance of cervical cancer screening is crucially dependent upon the prevalence of cervical dysplasia and/or HPV infection or vaccination in a given population, as well as the sensitivity and specificity of various modalities. Although screening is life-saving, false negatives and positives will occur, and over-testing may cause significant harm, including potential over-treatment.

A combined ultrastructural and gene molecular research for the relationship between human uterine cervical carcinoma and human papillomavirus

1990 ◽  
Vol 48 (3) ◽  
pp. 204-205
Author(s):  
Kun Lee ◽  
Jingyi Si ◽  
Ricai Han ◽  
Wei Zhang ◽  
Bingbing Tan ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Intraepithelial Neoplasia ◽  
Hpv Infection ◽  
Dot Blot ◽  
Homologous Sequences ◽  
Normal Cervical Epithelium ◽  
The Relationship ◽  
Chronic Cervicitis

There are more supports for the view that human papillomavirus (HPV) infection might be an etiological factor in the development of cervical cancer when the association of persistent condylomata is considered. Biopsies from 318 cases with squamous cell carcinoma of uterine cervix, 48 with cervical and vulvar condylomata, 14 with cervical intraepithelial neoplasia (CIN), 34 with chronic cervicitis and 24 normal cervical epithelium were collected from 5 geographic regions of China with different cervical cancer mortalities. All specimens were prepared for Dot blot, Southern blot and in situ DNA-DNA hybridizations by using HPV-11, 16, 18 DNA labelled with 32P and 3H as probes to detect viral homologous sequences in samples. Among them, 32 cases with cervical cancer, 27 with condyloma and 10 normal cervical epitheliums were randomly chosen for comparative EM observation. The results showed that: 1), 192 out of 318 (60.4%) cases of cervical cancer were positive for HPV-16 DNA probe (Table I)

Water-soluble amphiphilic ruthenium(ii) polypyridyl complexes as potential light-activated therapeutic agents

2020 ◽  
Vol 56 (65) ◽  
pp. 9332-9335
Author(s):  
Sandra Estalayo-Adrián ◽  
Salvador Blasco ◽  
Sandra A. Bright ◽  
Gavin J. McManus ◽  
Guillermo Orellana ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Therapeutic Agents ◽  
Water Soluble ◽  
Polypyridyl Complexes ◽  
Cervical Cancer Cells

Two new water-soluble amphiphilic Ru(ii) polypyridyl complexes were synthesised and their photophysical and photobiological properties evaluated; both complexes showed a rapid cellular uptake and phototoxicity against HeLa cervical cancer cells.

Stanniocalcin 1 enhanced sensitization of cervical cancer CaSki cells to anti-tumor drugs

2010 ◽  
Vol 34 (8) ◽  
pp. S49-S49
Author(s):  
Ya‑Lin Li ◽  
Feng‑Jie Guo ◽  
Jia‑Jia Wang ◽  
Yue‑Hui Li ◽  
Yan‑Hong Liu ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Tumor Drugs

The effect of multidisciplinary team integration on treatment completion disparities in women undergoing treatment for cervical cancer

2020 ◽  
Vol 159 ◽  
pp. 179-180
Author(s):  
A.L. Beavis ◽  
A.F. Rositch ◽  
A. Romero-Sackey ◽  
A. Viswanathan ◽  
A.N. Fader ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Multidisciplinary Team ◽  
Treatment Completion ◽  
Team Integration

Low-income minority women at risk for cervical cancer: a process to improve adherence to follow-up recommendations

2001 ◽  
Vol 116 (6) ◽  
pp. 608-616 ◽  
Author(s):  
Virginia A Cardin ◽  
Richard M Grimes ◽  
Zhi Dong Jiang ◽  
Nancy Pomeroy ◽  
Luther Harrell ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
At Risk ◽  
Low Income ◽  
Minority Women
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