SPECIFIC SECRETORY PROTEIN OF THE FEMALE GENITAL TRACT

ABSTRACT Investigations on the biochemical composition of genital tract secretions during oestrus and early reproductive stages reveal a spectrum of different substrate and time specific patterns, particularly of secretory proteins. Results are presented on the biochemistry, immunological specificity, and endocrinological regulation of rabbit female genital tract secretion proteins. Special attention is drawn upon uteroglobin, which is one of the genital tract specific proteins presumably involved in preimplantational blastocyst development. Since analytical data on rabbit genital tract secretion proteins accumulate, there is consequently a necessity for an approach to comparable studies in the human uterus. Discelectrophoretical patterns and immunochemical test results are presented in this paper which encourage further studies on human genital tract specific proteins with regard to human reproduction, particularly with its contraceptive and fertility problems.

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Immunohistochemical Analysis of Uroplakins, Urothelial Specific Proteins, in Ovarian Brenner Tumors, Normal Tissues, and Benign and Neoplastic Lesions of the Female Genital Tract

American Journal Of Pathology ◽

10.1016/s0002-9440(10)65206-6 ◽

1999 ◽

Vol 155 (4) ◽

pp. 1047-1050 ◽

Cited By ~ 42

Author(s):

Kumiko Ogawa ◽

Sonny L. Johansson ◽

Samuel M. Cohen

Keyword(s):

Genital Tract ◽

Female Genital Tract ◽

Immunohistochemical Analysis ◽

Normal Tissues ◽

Neoplastic Lesions ◽

Specific Proteins ◽

Brenner Tumors ◽

Female Genital

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The Endometrial Microbiome and Its Impact on Human Conception

International Journal of Molecular Sciences ◽

10.3390/ijms23010485 ◽

2022 ◽

Vol 23 (1) ◽

pp. 485

Author(s):

Bruno Toson ◽

Carlos Simon ◽

Inmaculada Moreno

Keyword(s):

Experimental Design ◽

Bacterial Communities ◽

Genital Tract ◽

Current Knowledge ◽

Female Genital Tract ◽

Uterine Cavity ◽

Human Reproduction ◽

Fertility Treatment ◽

Review Current ◽

Female Genital

Changes in the female genital tract microbiome are consistently correlated to gynecological and obstetrical pathologies, and tract dysbiosis can impact reproductive outcomes during fertility treatment. Nonetheless, a consensus regarding the physiological microbiome core inside the uterine cavity has not been reached due to a myriad of study limitations, such as sample size and experimental design variations, and the influence of endometrial bacterial communities on human reproduction remains debated. Understanding the healthy endometrial microbiota and how changes in its composition affect fertility would potentially allow personalized treatment through microbiome management during assisted reproductive therapies, ultimately leading to improvement of clinical outcomes. Here, we review current knowledge regarding the uterine microbiota and how it relates to human conception.

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Bacterial Colonization of the Female Upper Genital Tract

International Journal of Molecular Sciences ◽

10.3390/ijms20143405 ◽

2019 ◽

Vol 20 (14) ◽

pp. 3405 ◽

Cited By ~ 16

Author(s):

Adriana Peric ◽

Jürgen Weiss ◽

Nicolas Vulliemoz ◽

David Baud ◽

Milos Stojanov

Keyword(s):

Genital Tract ◽

Positive Impact ◽

Bacterial Colonization ◽

Female Genital Tract ◽

Reproductive Function ◽

General Assumption ◽

Human Reproduction ◽

Fallopian Tubes ◽

Technical Aspects ◽

Female Genital

Bacteria colonize most of the human body, and the female genital tract is not an exception. While the existence of a vaginal microbiota has been well established, the upper genital tract has been considered a sterile environment, with a general assumption that bacterial presence is associated with adverse clinical manifestation. However, recent metagenomic studies identified specific patterns of microbiota colonizing the uterus, fallopian tubes, ovaries, and placenta. These results need confirmation and further investigations since the data are only scarce. Bacterial colonization of these sites appears different from the vaginal one, despite evidence that vaginal bacteria could ascend to the upper genital tract through the cervix. Are these bacteria only commensal or do they play a role in the physiology of the female upper genital tract? Which are the genera that may have a negative and a positive impact on the female reproductive function? The aim of this review is to critically present all available data on upper genital tract microbiota and discuss its role in human reproduction, ranging from the technical aspects of these types of analyses to the description of specific bacterial genera. Although still very limited, research focusing on genital colonization of bacteria other than the vaginal milieu might bring novel insights into physiopathology of human reproduction.

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