ASYMMETRICAL GONADAL DIFFERENTIATION AND GONADOBLASTOMA

1975 ◽  
Vol 80 (4) ◽  
pp. 753-760 ◽  
Author(s):  
R. Coco ◽  
H. Chemes ◽  
C. Bergada ◽  
Juan Kraizer
Keyword(s):  
Y Chromosome ◽  
Peripheral Blood ◽  
Exploratory Laparotomy ◽  
Peripheral Blood Lymphocytes ◽  
Pathological Examination ◽  
Gonadal Differentiation ◽  
Fallopian Tubes ◽  
Buccal Smear ◽  
Sex Chromatin ◽  
The Right

ABSTRACT A 1010/12 years old virilized girl with the syndrome of asymmetrical gonadal differentiation is reported. The patient had a negative sex chromatin and positive Y chromatin (bright fluorescent body of Y chromosome) in the buccal smear and 45,X/46,XY karyotype in the peripheral blood lymphocytes. An exploratory laparotomy showed a small uterus, two Fallopian tubes, a tumoural testis on the right side and a streak on the left side. Pathological examination revealed the presence of gonadoblastoma in both gonads. The Y chromatin was identified on histological sections only on the side of the testis, and was absent on the streak and its gonadoblastoma's nests. The distribution of the different cell lines and the fluorescence of the Y chromosome is discussed in relation to gonadal differentiation and the occurrence of gonadoblastoma.

Rapid Y-chromosome-assay sexing of peripheral blood lymphocytes from bovinae of known phenotypic sex

1990 ◽  
Vol 33 (1) ◽  
pp. 246 ◽  
Author(s):  
Charles M. Herr ◽  
Klaus I. Matthaei ◽  
Trevor Steel ◽  
Ken C. Reed
Keyword(s):  
Y Chromosome ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes

scholarly journals Gangrenous ischaemic colitis following lung wedge resection

2019 ◽  
Vol 12 (5) ◽  
pp. e227908 ◽  
Author(s):  
Kazuki Hayashi ◽  
Yasuhiko Ohshio ◽  
Jun Hanaoka
Keyword(s):  
Mesenteric Artery ◽  
Creatine Phosphokinase ◽  
Wedge Resection ◽  
Lower Lobe ◽  
Exploratory Laparotomy ◽  
Pathological Examination ◽  
Ischaemic Colitis ◽  
Intestinal Necrosis ◽  
General Thoracic Surgery ◽  
The Right

A 77-year-old man, who was taking prednisolone 7.5 mg, underwent wedge resection for nodules in the right lower lobe of the lung. The nodules were diagnosed as amyloid tumour. On the sixth postoperative day, sudden tachycardia, fever, creatine phosphokinase increase, renal dysfunction and metabolic acidosis were observed. CT showed no signs of infection, exacerbation of interstitial pneumonia, pulmonary embolism or occlusion in the major vessels of the mesentery. Exploratory laparotomy revealed intestinal necrosis in the inferior mesenteric artery area, and left hemicolectomy was performed. Postoperative pathological examination revealed gangrenous ischaemic colitis. Although gangrenous ischaemic colitis is not a complication specific to general thoracic surgery, it can be fatal. Because of the high risk of developing gangrenous ischaemic colitis in elderly patients and the increase in concomitant diseases, thoracic surgeons should always be mindful of the condition.

scholarly journals Peripheral Lymphocyte Count, Free/Total PSA Ratio, LUTS Predict The Severity of Prostatic Inflammation in BPH Patients

2021 ◽  
Author(s):  
Shun Wan ◽  
Xiao-Hong Sun ◽  
Yong-Shuai Lin ◽  
Fang-Ming Du ◽  
Gong-Jun Guo ◽  
...  
Keyword(s):  
Peripheral Blood Lymphocyte ◽  
Peripheral Blood ◽  
Lymphocyte Count ◽  
Blood Lymphocyte ◽  
Clinical Laboratory ◽  
Multivariate Logistic Regression Analysis ◽  
Peripheral Blood Lymphocytes ◽  
Pathological Examination ◽  
Total Psa ◽  
Prostatic Inflammation

Abstract Objective To study the correlation between peripheral blood lymphocytes, f/t PSA and LUTS symptoms, and prostatic inflammation in BPH patients.Materials and Methods From May 2020 to October 2020, 120 patients (aged 56-85 years) with BPH undergoing elective transurethral resection of the prostate (TURP) were selected. Peripheral blood lymphocyte counts and f/t PSA values were measured preoperatively, and IPSS scores were assessed. Postoperative prostate tissues were sent for pathological examination, and the relationship between peripheral blood lymphocyte count, TPSA, f/t PSA values, relevant clinical laboratory parameters, and relevant LUTS symptoms and the distribution of prostate tissue inflammation was analyzed.Results with the aggravation of prostatic inflammation, IPSS score and TPSA value were lower, while f/t PSA value and lymphocyte count were lower. Multivariate logistic regression analysis of 120 BPH patients showed that age (> = 60) [odds ratio (OR) = 0.29, 95% CI = 0.31-2.10; P = 0.02], IPSS score [OR = 1.24, 95% CI = 1.13-1.37; P < 0.01], TPSA [OR = 1.10, 95% CI = 1.02-1.19; P = 0.02], f/t PSA [OR = 1.03, 95% CI = 0.01-0.15; P = 0.02], and lymphocytes [OR = 1.70, 95% CI = 0.78-3.77; P = 0.04] were related to the formation of prostatic inflammation in BPH patients. Conclusion Peripheral blood lymphocyte count, TPSA, LUTS severity, and f/t PSA ratio can predict the severity of prostatic inflammation, which may be used as diagnostic markers for BPH patients with LUTS symptoms who have prostatitis and promote the development of drug treatment for LUTS symptoms in BPH patients with prostatitis.

scholarly journals A "Philadelphia-like" Chromosome Derived From the Y in a Patient With Refractory Dysplastic Anemia

Blood ◽  
1973 ◽  
Vol 42 (5) ◽  
pp. 799-804 ◽  
Author(s):  
Dorothy Warburton ◽  
Avrum Bluming
Keyword(s):  
Y Chromosome ◽  
Peripheral Blood ◽  
Acrocentric Chromosome ◽  
Marrow Cell ◽  
Philadelphia Chromosome ◽  
Peripheral Blood Lymphocytes ◽  
Chronic Myelocytic Leukemia ◽  
Fluorescent Staining ◽  
Blood Lymphocytes ◽  
Myelocytic Leukemia

Abstract A small acrocentric chromosome, identical in appearance to the Philadelphia chromosome of chronic myelocytic leukemia, was identified in all karyotyped marrow cell metaphases prepared from a 74-yr-old male with refractory dysplastic anemia. The abnormal chromosome was shown by quinacrine fluorescent staining to be derived from a Y chromosome which has lost the characteristic brilliantly fluorescent material of its long arms. A normal Y chromosome was consistently observed in karyotypes of cultured peripheral blood lymphocytes from this patient.

A MASCULINIZING MIXED GERM CELL TUMOUR (GONOCYTOMA III)

1964 ◽  
Vol 46 (1) ◽  
pp. 1-11 ◽  
Author(s):  
J. Teter ◽  
J. Philip ◽  
Gr. Wecewicz ◽  
J. Potocki
Keyword(s):  
Germ Cell ◽  
Y Chromosome ◽  
Germ Cell Tumour ◽  
Cell Tumour ◽  
Fallopian Tubes ◽  
Primary Amenorrhoea ◽  
Chromatin Pattern ◽  
Sex Chromatin ◽  
Important Evidence

ABSTRACT A case is presented of gonocytoma III (gonadoblastoma), which was diagnosed in a patient, aged 19 years who had been brought up as a woman, and who had primary amenorrhoea, and some signs of masculinization. The sex chromatin pattern was negative, and the urinary gonadotrophin titre was increased. Laparotomy disclosed a uterus, fallopian tubes and bilateral knob-like gonadal tumours. It was found that the karyotype was 46/XY. The authors discuss the pathogenesis of gonocytoma III and believe that the presence of a Y chromosome is important evidence that such dysgenetic gonadal tumours develop in a »testis«.

Prepubertal XY Gonadal Dysgenesis

PEDIATRICS ◽  
1977 ◽  
Vol 59 (4) ◽  
pp. 569-573
Author(s):  
Koichiro Isurugi ◽  
Yoshio Aso ◽  
Hajime Ishida ◽  
Toru Suzuki ◽  
Tadao Kakizoe ◽  
...  
Keyword(s):  
Y Chromosome ◽  
Genetic Predisposition ◽  
Gonadal Dysgenesis ◽  
Ovarian Tumor ◽  
Exploratory Laparotomy ◽  
Physical Development ◽  
Second Child ◽  
Xy Gonadal Dysgenesis ◽  
Cryptorchid Testis ◽  
The Right

Two children had prepubertal XY gonadal dysgenesis. A 7-year-old girl with clitoral enlargement had a left ovarian tumor that contained a dysgerminoma; the right gonad proved to be a gonadoblastoma. The second child (a 2-year-old girl) showed poor physical development and slight virilization of the genitalia. Her bilateral dysgenetic gonads were removed at exploratory laparotomy. The occurrence of gonadal tumors in XY gonadal dysgenesis is increased. It is probably related to the hypergonadotropinism existing from childhood as well as to genetic predisposition of the cryptorchid testis in the presence of a Y chromosome. Our first patient is one of the youngest who had XY gonadal dysgenesis with gonadoblastoma reported. The indication of prophylactic gonadectomy in XY gonadal dysgenesis is emphasized.

A Quantitative Ultrastructural Study of Peripheral Blood Lymphocytes Containing Parallel Tubular Arrays in Epstein-Barr Virus and Cytomegalo-Virus Mononucleosis

1981 ◽  
Vol 39 ◽  
pp. 454-455
Author(s):  
C. M. Payne ◽  
P. M. Tennican
Keyword(s):  
Peripheral Blood ◽  
Lymphocyte Count ◽  
Epstein Barr Virus ◽  
Absolute Lymphocyte Count ◽  
Peripheral Blood Lymphocytes ◽  
Clinical State ◽  
Barr Virus ◽  
The Absolute ◽  
Epstein Barr ◽  
Tubular Arrays

In the normal peripheral circulation there exists a sub-population of lymphocytes which is ultrastructurally distinct. This lymphocyte is identified under the electron microscope by the presence of cytoplasmic microtubular-like inclusions called parallel tubular arrays (PTA) (Figure 1), and contains Fc-receptors for cytophilic antibody. In this study, lymphocytes containing PTA (PTA-lymphocytes) were quantitated from serial peripheral blood specimens obtained from two patients with Epstein -Barr Virus mononucleosis and two patients with cytomegalovirus mononucleosis. This data was then correlated with the clinical state of the patient.It was determined that both the percentage and absolute number of PTA- lymphocytes was highest during the acute phase of the illness. In follow-up specimens, three of the four patients' absolute lymphocyte count fell to within normal limits before the absolute PTA-lymphocyte count.In one patient who was followed for almost a year, the absolute PTA- lymphocyte count was consistently elevated (Figure 2). The estimation of absolute PTA-lymphocyte counts was determined to be valid after a morphometric analysis of the cellular areas occupied by PTA during the acute and convalescent phases of the disease revealed no statistical differences.

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