BEFUNDE AM GENITALTRAKTUS DER RATTE NACH CORTICOTROPIN-INJECTION UND IHRE DEUTUNG UNTER BERÜCKSICHTIGUNG DES ZELLBILDES DER ADENOHYPOPHYSE

1959 ◽  
Vol XXXII (II) ◽  
pp. 167-176 ◽  
Author(s):  
Walter Schätzle
Keyword(s):  
Adult Female ◽  
Single Injection ◽  
Anterior Lobe ◽  
Vaginal Epithelium ◽  
Female Rats ◽  
Normal Adult ◽  
List Type

ABSTRACT In normal adult female rats a single injection of 5 IU corticotrophin was followed by a retention of glucoproteid material in the anterior lobe of the hypophysis and by impairment of the luteinization. In spayed adult female rats the same corticotrophin administration caused stratification and mucification of the vaginal epithelium.

EFFECTS OF SINGLE INJECTIONS OF BOVINE FOLLICULAR FLUID ON GONADOTROPHIN CONCENTRATIONS THROUGHOUT THE OESTROUS CYCLE OF THE RAT

1982 ◽  
Vol 92 (3) ◽  
pp. 425-432 ◽  
Author(s):  
W. P. HERMANS ◽  
M. H. M. DEBETS ◽  
E. C. M. VAN LEEUWEN ◽  
F. H. DE JONG
Keyword(s):  
Adult Female ◽  
Follicular Fluid ◽  
Single Injection ◽  
Oestrous Cycle ◽  
Female Rats ◽  
Follicular Maturation ◽  
Selective Suppression ◽  
Plasma Injection ◽  
Bovine Plasma

A single injection of steroid-free bovine follicular fluid (bFF), which contains inhibin-like activity, was given to adult female rats at 09.00 h on dioestrus-2 (the day after metoestrus), dioestrus-3, pro-oestrus or oestrus. Peripheral concentrations of gonadotrophins were measured at 2-h intervals after injection. Compared with values in control animals treated with bovine plasma, injection of bFF did not influence concentrations of LH. In contrast, at all days studied injection of bFF resulted in suppressed concentrations of FSH, during a period which started between 4 and 10 h after injection and lasted 4–12 h, depending on the day of the cycle. With the exception of pro-oestrus, the period of suppression was followed by one in which fluctuating levels of FSH were found; in general, resulting levels were higher though not significantly increased. This latter effect was most pronounced on dioestrus-2 and dioestrus-3, when levels of FSH, which were already low in control animals, were first suppressed during the 6 h after injection of bFF. These data, in conjunction with results from an earlier study in rats at dioestrus-1, showed that administration of bFF induces a fast and selective suppression of FSH secretion on all days of the cycle. This period of suppression was followed by one with fluctuating levels of FSH which showed a tendency to be higher, indicating that disturbances in FSH secretion, such as are caused by bFF, can be compensated for quickly. In this way the process of follicular maturation might be protected.

THE REACTION OF THE OVARIES AND ADRENAL GLANDS OF FEMALE RATS TO OVARIAN AND MUSCLE HOMOGRAFTS

1951 ◽  
Vol 7 (4) ◽  
pp. 344-348 ◽  
Author(s):  
ANITA M. MANDL ◽  
S. ZUCKERMAN
Keyword(s):  
Body Weight ◽  
Muscle Tissue ◽  
Adult Female ◽  
Adrenal Glands ◽  
Female Rats ◽  
Normal Adult ◽  
Adrenal Weight ◽  
Ovarian Weight ◽  
Adult Rat

The ovaries and adrenal glands of an adult rat hypertrophy after either ovarian or muscle tissue is homografted into the animal. The ovarian weight/body weight and adrenal weight/body weight ratios become significantly higher than those of normal adult female rats derived from the same colony. Anaesthesia also appears to lead to a transitory increase in the weight of the adrenals. The possibility that the ovaries respond to certain non-specific conditions, in the same general way as do the adrenal glands, is discussed.

TIME-RELATED SECRETION OF GONADOTROPHINS AFTER A SINGLE INJECTION OF STEROID-FREE BOVINE FOLLICULAR FLUID IN PREPUBERTAL AND ADULT FEMALE RATS

1981 ◽  
Vol 90 (1) ◽  
pp. 69-76 ◽  
Author(s):  
W. P. HERMANS ◽  
M. H. M. DEBETS ◽  
E. C. M. VAN LEEUWEN ◽  
F. H. DE JONG
Keyword(s):  
Adult Female ◽  
Follicular Fluid ◽  
Single Injection ◽  
Female Rats ◽  
Adult Rats ◽  
Total Period ◽  
Normal Number ◽  
Pituitary Secretion ◽  
Old Rats ◽  
Intact Rats

The time-related changes in gonadotrophin concentrations after a single injection of steroid-free bovine follicular fluid (bFF), which contains material with inhibin-like activity, were studied in 25-day-old and adult female rats which either were intact or had been ovariectomized 2 days before. In ovariectomized and intact rats administration of bFF caused a selective suppression of FSH after 4–8 h in 25-day-old rats and after 3–4 h in adult rats. No systematic changes in concentrations of LH after bFF injection were observed. Relative suppression of FSH levels in adult rats was more pronounced and of longer duration than in 25-day-old rats. Moreover, the total period of suppression lasted longer in ovariectomized than in intact rats (12 and 8 h for 25-day-old and 24 and 15 h for adult rats respectively). Hypersecretion of FSH was found in intact rats after the initial suppression; this phenomenon was more pronounced and of longer duration in adult than in 25-day-old rats. No clear change in the numbers of healthy growing follicles was observed after injection of bFF into intact rats. These results indicate that the pituitary secretion of FSH responds quickly and selectively after administration of bFF to intact and ovariectomized, 25-day-old and adult female rats. The hypersecretion of FSH in intact rats might compensate for the initial suppression of this gonadotrophin, and may thus ensure the maturation of a normal number of follicles.

Effects of long-term oral nitrate administration on adiposity in normal adult female rats

Life Sciences ◽  
2018 ◽  
Vol 210 ◽  
pp. 76-85 ◽  
Author(s):  
Fatemeh Bakhtiarzadeh ◽  
Fatemeh Siavoshi ◽  
Sevda Gheibi ◽  
Khosrow Kashfi ◽  
Roghaieh Samadi ◽  
...  
Keyword(s):  
Adult Female ◽  
Female Rats ◽  
Normal Adult

scholarly journals The action of testosterone propionate on normal adult female rats

1937 ◽  
Vol 31 (5) ◽  
pp. 780-785 ◽  
Author(s):  
Vladimir Korenchevsky ◽  
Marjorie Dennison ◽  
Kathleen Hall
Keyword(s):  
Adult Female ◽  
Testosterone Propionate ◽  
Female Rats ◽  
Normal Adult

The Fine Structure of Rat Granulosa Cell Cultures Correlated with Progestin Secretion

1973 ◽  
Vol 31 ◽  
pp. 552-553
Author(s):  
T. M. Crisp ◽  
F.R. Denys
Keyword(s):  
Fine Structure ◽  
Granulosa Cell ◽  
Cell Cultures ◽  
Single Injection ◽  
Surrounding Medium ◽  
Petri Dish ◽  
Female Rats ◽  
Vaginal Smear ◽  
Immature Female ◽  
Serum Gonadotropin

The purpose of this paper is to present observations on the fine structure of rat granulosa cell cultures grown in the presence of an adenohypophyseal explant and to correlate the morphology of these cells with progestin secretion. Twenty-six day old immature female rats were given a single injection of 5 IU pregnant mares serum gonadotropin (PMS) in order to obtain ovaries with large vesicular follicles. At 66 hrs. post-PMS administration (estrus indicated by vaginal smear cytology), the ovaries were removed and placed in a petri dish containing medium 199 and 100 U penicillin/streptomycin (P/S)/ml. Under a 20X magnification dissecting microscope, some 5-8 vesicular follicles/ovary were punctured and the granulosa cells were expressed into the surrounding medium. The cells were transferred to centrifuge tubes and spun down at 1000 rpm for 5 mins.

Modification of Pineal Ultrastructure by Exogenous Hormones

1967 ◽  
Vol 25 ◽  
pp. 170-171
Author(s):  
R. A. Turner ◽  
A. E. Rodin ◽  
D. K. Roberts
Keyword(s):  
Electron Microscopy ◽  
Endoplasmic Reticulum ◽  
Rough Endoplasmic Reticulum ◽  
Estradiol Benzoate ◽  
Female Rats ◽  
List Type ◽  
Type Number ◽  
Pregnant Rats ◽  
Gonadal Atrophy ◽  
Pineal Ultrastructure

There have been many reports which establish a relationship between the pineal and sexual structures, including gonadal hypertrophy after pinealectomy, and gonadal atrophy after injection of pineal homogenates or of melatonin. In order to further delineate this relationship the pineals from 5 groups of female rats were studied by electron microscopy:ControlsPregnant ratsAfter 4 weekly injections of 0.1 mg. estradiol benzoate.After 8 daily injections of 150 mcgm. melatonin (pineal hormone).After 8 daily injections of 3 mg. serotonin (melatonin precursor).No ultrastructural differences were evident between the control, and the pregnancy and melatonin groups. However, the estradiol injected animals exhibited a marked increase in the amount and size of rough endoplasmic reticulum within the pineal cells.

CORTICOSTEROID-UMSATZ UND CORTICOSTEROID-PRODUKTION BEI RATTEN UNTER DER BEHANDLUNG MIT ANABOLEN STEROIDEN

1965 ◽  
Vol 48 (2) ◽  
pp. 263-271 ◽  
Author(s):  
Herbert Schriefers ◽  
Gerlinde Scharlau ◽  
Franzis Pohl
Keyword(s):  
Production Rate ◽  
Adult Female ◽  
Anabolic Steroids ◽  
Reduction Rate ◽  
Female Rats ◽  
Adrenal Weight ◽  
Hydrogenase Activity ◽  
Anabolic Effect ◽  
Liver Slices

ABSTRACT After the administration of anabolic steroids to adult female rats in daily doses of 1 mg per animal for 14 days, the following parameters were investigated: the rate of the Δ4-5α-hydrogenase-catalyzed cortisone reduction in liver slices and microsomal fractions, the adrenal weight and the in vitro corticosterone production rate. Among the steroids tested, only 17α-methyl-testosterone and 17α-ethyl-19-nor-testosterone were effective in lowering significantly cortisone reduction rate by liver slices with concomitant decreases in microsomal Δ4-5α-hydrogenase-activity. Testosterone, 19-nor-testosterone, 17α-ethinyl-19-nor-testosterone, 17α-methyl-17β-hydroxy-androsta-1,4-dien-3-one and 1-methyl-17β-hydroxy-androst-1-en-3-one were ineffective or only slightly effective. Adrenal weight and absolute corticosterone production rate (μg/60 min per animal) were decreased after treatment with 17α-methyl-testosterone, 17α-ethyl-19-nor-testosterone and 1-methyl-17β-hydroxy-androst-1-en-3-one. Corticosterone production was decreased with 17α-ethinyl-19-nor-testosterone in spite of an unchanged adrenal weight. The relative corticosterone production rate (μg/60 min · 100 mg adrenal) was in any cases unaffected. According to these results there exists – with the exception of 17α-ethinyl-19-nor-testosterone – a strict parallelism between corticosteroid turnover and corticosterone production rate: unchanged turnover is correlated with unchanged corticosterone production rate, while a decreased turnover is correlated with decreased adrenal activity. The protein-anabolic effect of certain anabolic steroids may be partly due to an anti-catabolic action of these compounds resulting from a decreased corticosteroid inactivation and production rate. Possible mechanisms by which anabolic steroids may affect corticosteroid-balance are discussed.

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