scholarly journals Reference intervals for bone turnover markers in Spanish premenopausal women

2014 ◽  
Author(s):  
Nuria Guanabens ◽  
◽  
Xavier Filella ◽  
Ana Monegal ◽  
Carmen Gomez-Vaquero ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Premenopausal Women ◽  
Reference Intervals ◽  
Turnover Markers

Reference intervals of bone turnover markers in healthy premenopausal women: Results from a cross-sectional European study

Bone ◽  
2012 ◽  
Vol 50 (5) ◽  
pp. 1141-1147 ◽  
Author(s):  
Richard Eastell ◽  
Patrick Garnero ◽  
Christine Audebert ◽  
David L. Cahall
Keyword(s):  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Premenopausal Women ◽  
Reference Intervals ◽  
European Study ◽  
Cross Sectional ◽  
Turnover Markers

SAT0486 Reference Intervals for Bone Turnover Markers in Spanish Premenopausal Women

2014 ◽  
Vol 73 (Suppl 2) ◽  
pp. 769.1-769
Author(s):  
N. Guañabens ◽  
X. Filella ◽  
A. Monegal ◽  
C. Gomez-Vaquero ◽  
M. Bonet ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Premenopausal Women ◽  
Reference Intervals ◽  
Turnover Markers

Bone turnover marker reference intervals in young females

2016 ◽  
Vol 54 (4) ◽  
pp. 438-447 ◽  
Author(s):  
Emma T Callegari ◽  
Alexandra Gorelik ◽  
Suzanne M Garland ◽  
Cherie Y Chiang ◽  
John D Wark
Keyword(s):  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Bone Turnover Marker ◽  
Reference Intervals ◽  
Cross Linking ◽  
Young Females ◽  
Procollagen Type ◽  
Turnover Markers ◽  
Carboxy Terminal

Background The use of bone turnover markers in clinical practice and research in younger people is limited by the lack of normative data and understanding of common causes of variation in bone turnover marker values in this demographic. To appropriately interpret bone turnover markers, robust reference intervals specific to age, development and sex are necessary. This study aimed to determine reference intervals of bone turnover markers in females aged 16–25 years participating in the Safe-D study. Methods Participants were recruited through social networking site Facebook and were asked to complete an extensive, online questionnaire and attend a site visit. Participants were tested for serum carboxy-terminal cross-linking telopeptide of type 1 collagen and total procollagen type 1 N-propeptide using the Roche Elecsys automated analyser. Reference intervals were determined using the 2.5th to 97.5th percentiles of normalized bone turnover marker values. Results Of 406 participants, 149 were excluded due to medical conditions or medication use (except hormonal contraception) which may affect bone metabolism. In the remaining 257 participants, the reference interval was 230–1000 ng/L for serum carboxy-terminal cross-linking telopeptide of type 1 collagen and 27–131  µg/L for procollagen type 1 N-propeptide. Both marker concentrations were inversely correlated with age and oral contraceptive pill use. Therefore, intervals specific to these variables were calculated. Conclusions We defined robust reference intervals for cross-linking telopeptide of type 1 collagen and procollagen type 1 N-propeptide in young females grouped by age and contraceptive pill use. We examined bone turnover markers’ relationship with several lifestyle, clinical and demographic factors. Our normative intervals should aid interpretation of bone turnover markers in young females particularly in those aged 16 to 19 years where reference intervals are currently provisional.

Age-related changes and reference intervals of RANKL, OPG, and bone turnover markers in Indian women

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Sandhya Nair ◽  
Sonam Hatkar ◽  
Anushree Patil ◽  
Suchitra Surve ◽  
Beena Joshi ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Reference Intervals ◽  
Indian Women ◽  
Age Related ◽  
Turnover Markers ◽  
Age Related Changes

Age-related reference intervals for bone turnover markers from an Australian reference population

Bone ◽  
2013 ◽  
Vol 55 (2) ◽  
pp. 271-276 ◽  
Author(s):  
N. Jenkins ◽  
M. Black ◽  
E. Paul ◽  
J.A. Pasco ◽  
M.A. Kotowicz ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Reference Population ◽  
Reference Intervals ◽  
Age Related ◽  
Turnover Markers

Determinants of Bone Turnover Markers in Healthy Premenopausal Women

2008 ◽  
Vol 82 (5) ◽  
pp. 341-347 ◽  
Author(s):  
Silvano Adami ◽  
Gerolamo Bianchi ◽  
Maria Luisa Brandi ◽  
Sandro Giannini ◽  
Sergio Ortolani ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Premenopausal Women ◽  
Turnover Markers

scholarly journals Establishing Reference Intervals for Bone Turnover Markers in the Healthy Shanghai Population and the Relationship with Bone Mineral Density in Postmenopausal Women

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Wei-Wei Hu ◽  
Zeng Zhang ◽  
Jin-Wei He ◽  
Wen-Zhen Fu ◽  
Chun Wang ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Turnover ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Reference Intervals ◽  
Type I ◽  
Reference Ranges ◽  
Mineral Density ◽  
Turnover Markers

The reference ranges of bone turnover markers (BTMs) were important during the treatment of osteoporosis, and the associations with bone mineral density (BMD) were controversial. The aim of this study was to establish the reference ranges of N-terminal procollagen of type l collagen (P1NP), osteocalcin (OC), and beta C-terminal cross-linked telopeptides of type I collagen (β-CTX) in Shanghai area and to investigate the relationships between BTMs and BMD in postmenopausal women. 2,799 subjects recruited in Shanghai City were measured BTMs to establish the reference ranges. Additional 520 healthy postmenopausal women were also measured BTMs, these women measured BMD in addition. BTMs were measured using the Roche electrochemiluminescence system. We used the age range of 35 to 45-year-olds to calculate reference intervals. The reference range of OC was 4.91 to 13.90 ng/mL for women and 5.58 to 16.57 ng/mL for men, P1NP was 13.72 to 32.90 ng/mL for women and 16.89 to 42.43 ng/mL for men, andβ-CTX was 0.112 to 0.210 ng/mL for women and 0.100 to 0.378 ng/mL for men. BTMs significantly negatively correlated with lumbar spine and femoral and total hip in postmenopausal women ( = −0.157~−0.217,P< 0.001). We established the normal reference ranges of P1NP, OC, andβ-CTX in the Shanghai area. This study also found that BTMs correlated with BMD and suggested that BTMs were the key determining factors of early BMD decreases.

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