scholarly journals Elevated serum levels of adiponectin in children, adolescents and young adults with type 1 diabetes and the impact of age, gender, body mass index and metabolic control: a longitudinal study

2007 ◽  
Vol 157 (4) ◽  
pp. 481-489 ◽  
Author(s):  
Angela Galler ◽  
Götz Gelbrich ◽  
Jürgen Kratzsch ◽  
Nicole Noack ◽  
Thomas Kapellen ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Type 1 Diabetes ◽  
Children And Adolescents ◽  
Metabolic Control ◽  
Elevated Serum ◽  
Serum Levels ◽  
Healthy Children ◽  
The Impact

Objective: Adiponectin plays an important role in pathophysiology of obesity, type 2 diabetes and cardiovascular disease. The aim of this study was to determine adiponectin concentrations in children and adolescents with type 1 diabetes in a longitudinal manner and to study the impact of age, gender, body mass index (BMI) and metabolic control. Research design and methods: In this study, 88 children and adolescents with type 1 diabetes were followed longitudinally. At baseline and during follow-up, serum levels of adiponectin were measured by enzyme-linked immunoassay and correlated with clinical data, HbA1c and lipids. Healthy children (n = 259) were chosen as a control group. Results: Serum adiponectin levels were significantly higher in children with type 1 diabetes compared with healthy children (13.1 vs 9.1 μg/ml at baseline, P < 0.001). Adiponectin concentrations inversely correlated with BMI s.d.s (P < 0.001). No significant difference of adiponectin levels regarding gender, diabetes duration or HbA1c was seen. Adiponectin concentrations decreased in males with type 1 diabetes during puberty (P = 0.03) while there was no significant change in females. In a subgroup of patients with new onset type 1 diabetes, adiponectin concentrations were not different from adiponectin levels in control subjects but increased during follow-up (P = 0.007). Stepwise multiple regression analysis showed that most important predictors of adiponectin levels in type 1 diabetes at the end of the study were adiponectin concentration at baseline (β = 0.574, P < 0.001) and BMI s.d.s (β = −0.302, P = 0.001, r2 = 0.56). Conclusions: Children and adolescents with type 1 diabetes have BMI-dependent elevated serum concentrations of adiponectin compared with healthy children.

Anthropometry, Metabolic Control, and Follow-Up in Children and Adolescents with Type 1 Diabetes Mellitus and Biopsy-Proven Celiac Disease

2011 ◽  
Vol 158 (4) ◽  
pp. 589-593.e2 ◽  
Author(s):  
Elke E. Fröhlich-Reiterer ◽  
Stefan Kaspers ◽  
Sabine Hofer ◽  
Edith Schober ◽  
Olga Kordonouri ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Celiac Disease ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Metabolic Control

scholarly journals Increased serum soluble leptin receptor levels in children and adolescents with type 1 diabetes mellitus

2004 ◽  
pp. 475-481 ◽  
Author(s):  
J Kratzsch ◽  
A Deimel ◽  
A Galler ◽  
T Kapellen ◽  
A Klinghammer ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Leptin Receptor ◽  
Serum Levels ◽  
Healthy Children ◽  
Duration Of Diabetes ◽  
Soluble Leptin Receptor

OBJECTIVE: We investigated whether or not serum levels of the soluble leptin receptor (sOB-R) and leptin are related to anthropometric and metabolic changes during pubertal development of children and adolescents with type 1 diabetes mellitus. DESIGN AND METHODS: Blood levels of sOB-R, leptin and HbA1C, as well as body-mass index (BMI), diabetes duration and daily insulin doses, were determined in 212 (97 girls; 115 boys) children with type 1 diabetes mellitus and compared with the sOB-R serum levels in 526 healthy children and adolescents. RESULTS: OB-R serum levels and parallel values of the molar ratio between sOB-R and leptin were significantly higher in children with diabetes than in normal children (P<0.05) in almost all investigated Tanner stages. Furthermore, in the entire group of patients, we demonstrated statistically significant correlations (P<0.02) between sOB-R and the duration of diabetes (r=0.30), HbA1c levels (r=0.32) and the insulin dose (r=0.18). Multiple-regression analysis revealed that HbA1c (12.4%), height (7.9%) and duration of diabetes (8.7%) contributed to 29% variance of sOB-R in diabetic children. CONCLUSIONS: Our data suggest that poor glycemic control in diabetes may lead to increased serum levels of sOB-R. This regulation of sOB-R appears to be independent of leptin, but may have an impact on leptin action. The consequently developing molar excess of sOB-R related to leptin could reduce leptin sensitivity and may, therefore, influence leptin-related anthropometric and metabolic abnormalities.

Impact of childhood type 1 diabetes on maternal work-family relations

2018 ◽  
Vol 31 (5) ◽  
pp. 569-576 ◽  
Author(s):  
Shlomit Shalitin ◽  
Efrat Hershtik ◽  
Moshe Phillip ◽  
Michal-Yackobovitz Gavan ◽  
Rachel Gali Cinamon
Keyword(s):  
Type 1 Diabetes ◽  
Working Mothers ◽  
Diabetes Management ◽  
Working Hours ◽  
Healthy Children ◽  
Organizational Resources ◽  
Work Family ◽  
The Impact

Abstract Background: The aim of the study was to evaluate work-family conflict (WFC) and work-family facilitation (WFF) of working mothers of children with type 1 diabetes (T1D) compared with those of working mothers of children under follow-up not requiring treatment and of healthy children, and to explore the impact of organizational resources and the characteristics of the child and his disease on this interface. Methods: The study included 157 working mothers: 50 mothers of children with T1D, 50 mothers of children on medical follow-up without chronic illness and 57 mothers of healthy children. The participants completed validated questionnaires including the WFC scale, WFF scale, organizational resources support scale, life and work satisfaction questionnaire, a background demographic questionnaire and a child health questionnaire. Mothers of children with T1D also completed a questionnaire relating to diabetes management. Results: Almost half of the mothers of children with T1D found it necessary to reduce their working hours or to change their workplace. This group also reported a significantly higher level of colleague support. There were no significant differences in WFC and WFF between mothers of children with T1D and controls. Conclusions: This study demonstrates the effect of raising a T1D child on the mother’s vocational behavior. Despite the additional burden, work is a source of enrichment for these mothers.

The impact of real-time continuous glucose monitoring on metabolic control in children with type 1 diabetes

2020 ◽  
Author(s):  
Ruxandra Calapod Ioana ◽  
Irina Bojoga ◽  
Duta Simona Gabriela ◽  
Ana-Maria Stancu ◽  
Amalia Arhire ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Real Time ◽  
Metabolic Control ◽  
Continuous Glucose Monitoring ◽  
Glucose Monitoring ◽  
The Impact

scholarly journals Prevalence of dental caries in children and adolescents with type 1 diabetes: a systematic review and meta-analysis

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Yan Wang ◽  
Lin Xing ◽  
Hui Yu ◽  
LiJuan Zhao
Keyword(s):  
Type 1 Diabetes ◽  
Dental Caries ◽  
Children And Adolescents ◽  
Metabolic Control ◽  
Meta Analysis ◽  
Preventive Treatment ◽  
Diabetic Patients ◽  
China National Knowledge Infrastructure ◽  
Pooled Prevalence

Abstract Background Dental caries and type 1 diabetes are responsible for a large burden of global disease; however, the exact prevalence of dental caries among children and adolescents with type 1 diabetes remains controversial, and no quantitative meta-analysis exists. Thus, we performed a meta-analysis to evaluate the prevalence of dental caries among children and adolescents with type 1 diabetes. Methods We performed a systematic search strategy using PubMed, EMBASE and China National Knowledge Infrastructure for relevant studies investigating the prevalence of dental caries in children and adolescents with type 1 diabetes from July 1971 until December 2018. The pooled prevalence with 95% confidence intervals (95%CIs) and subgroup analyses were calculated using a random effects model. Results After screening 358 non-duplicated articles, a total of 10 articles involving 538 individuals were included. The overall prevalence of dental caries among children and adolescents with type 1 diabetes was 67% (95% CI: 0.56–0.77%; I2 = 83%). The prevalence was highest in South America (84%) and lowest in diabetic patients with good metabolic control (47%). Conclusions The prevalence of dental caries was high among children and adolescents with type 1 diabetes. Screening and preventive treatment should be included in dental clinical routines for diabetic children and adolescents, especially in those with poor metabolic control.

New glycemic metrics and traditional clinical and laboratory profiles of children and adolescents with type 1 diabetes mellitus in an outpatient follow-up

2021 ◽  
Vol 173 ◽  
pp. 108680
Author(s):  
Ricardo Rodrigues ◽  
Isabela Cristina Borges Rossi ◽  
Bruno Franco Rossi ◽  
Débora Cristiane Gomes ◽  
Nilson Penha-Silva
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents

The relation between awareness of personal resources and metabolic control in children and adolescents with type 1 diabetes

2014 ◽  
Vol 16 (6) ◽  
pp. 454-461 ◽  
Author(s):  
Maren Blicke ◽  
Ulrike Körner ◽  
Patricia Nixon ◽  
Burak Salgin ◽  
Thomas Meissner ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Children And Adolescents ◽  
Metabolic Control ◽  
Personal Resources
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