Prevalence of dental caries in children and adolescents with type 1 diabetes: a systematic review and meta-analysis

Abstract Background Dental caries and type 1 diabetes are responsible for a large burden of global disease; however, the exact prevalence of dental caries among children and adolescents with type 1 diabetes remains controversial, and no quantitative meta-analysis exists. Thus, we performed a meta-analysis to evaluate the prevalence of dental caries among children and adolescents with type 1 diabetes. Methods We performed a systematic search strategy using PubMed, EMBASE and China National Knowledge Infrastructure for relevant studies investigating the prevalence of dental caries in children and adolescents with type 1 diabetes from July 1971 until December 2018. The pooled prevalence with 95% confidence intervals (95%CIs) and subgroup analyses were calculated using a random effects model. Results After screening 358 non-duplicated articles, a total of 10 articles involving 538 individuals were included. The overall prevalence of dental caries among children and adolescents with type 1 diabetes was 67% (95% CI: 0.56–0.77%; I2 = 83%). The prevalence was highest in South America (84%) and lowest in diabetic patients with good metabolic control (47%). Conclusions The prevalence of dental caries was high among children and adolescents with type 1 diabetes. Screening and preventive treatment should be included in dental clinical routines for diabetic children and adolescents, especially in those with poor metabolic control.

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Changes from 1986 to 2018 in the Prevalence of Obesity and Overweight, Metabolic Control and Treatment in Children with Type 1 Diabetes Mellitus

10.21203/rs.3.rs-669040/v1 ◽

2021 ◽

Author(s):

María Teresa Pastor-Fajardo ◽

María Teresa Fajardo-Giménez ◽

Vicente Bosch-Giménez ◽

José Pastor-Rosado

Keyword(s):

Type 1 Diabetes ◽

Children And Adolescents ◽

Metabolic Control ◽

Overweight And Obesity ◽

World Health ◽

Diabetic Patients ◽

Cross Sectional ◽

Diabetic Children ◽

Health Organization

Abstract Background: In recent decades, a global increase in the prevalence of childhood overweight and obesity has been observed in children and adolescents with type 1 diabetes.Methods: This retrospective, cross-sectional, population study examined three groups (1986, 2007, and 2018) of children and adolescents aged <16 years diagnosed with type 1 diabetes. Overweight and obesity were defined according to the World Health Organization recommendations.Results: The prevalence of overweight and obesity in diabetic children and adolescents was 30.2% (95% CI: 23.1-38.3). There was a significant increase from 1986 to 2007 (11.9% to 41.7%, p=0.002) and from 1986 to 2018 (11.9% to 34.8%, p=0.012), but no significant differences were found from 2007 to 2018 (41.7% to 34.8%, p=0.492). The age at diagnosis was lower in the group with excess body mass (p=0.037). No significant differences were observed in age (p=0.690), duration of diabetes (p=0.163), distribution according to sex (p=0.452), metabolic control (HbA1c, p=0.909), or insulin units kg/day (p=0.566), in diabetic patients with overweight or obesity. From 2007 to 2018, the use of insulin analogs (p=0.009) and a higher number of insulin doses (p=0.007) increased significantly, with no increase in the prevalence of overweight and obesity.Conclusions: The evolution of the prevalence of overweight and obesity in diabetic children and adolescents during the study period is a reflection of the epidemic of childhood obesity in a global obesogenic environment.

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Global prevalence of metabolic syndrome among patients with type I diabetes mellitus: a systematic review and meta-analysis

Diabetology & Metabolic Syndrome ◽

10.1186/s13098-021-00641-8 ◽

2021 ◽

Vol 13 (1) ◽

Author(s):

Rebuma Belete ◽

Zerihun Ataro ◽

Ahmedmenewer Abdu ◽

Merga Sheleme

Keyword(s):

Diabetes Mellitus ◽

Metabolic Syndrome ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Meta Analysis ◽

Diabetic Patients ◽

Type I ◽

Pooled Prevalence ◽

Diabetes Patients

Abstract Background The presence of metabolic syndrome among diabetes patients is frequent and is associated with an increased incidence of chronic complications and mortality. Despite several studies have been conducted, there is no overall estimation on the prevalence of metabolic syndrome among type 1 diabetic patients. Therefore, this study aimed to estimate the pooled prevalence of metabolic syndrome among patients with type 1 diabetes mellitus. Methods Medline via PubMed, CINAHL, ScienceDirect, Ovid, Google Scholar, ResearchGate and African Journals Online were searched by limiting publication period from January 2005 to October 2020. Data were extracted with a standardized format prepared in Microsoft Excel and exported to Stata 16.0 for analyses. The I2 statistic was used to check heterogeneity across the included studies. DerSimonian and Laird random-effects model was applied to estimate pooled prevalence and 95% confidence interval across studies. Funnel plot symmetry, Begg’s test and Egger’s regression test were used to determine the presence of publication bias. Subgroup and sensitivity analysis as well as meta-regression were conducted to explore the potential sources of heterogeneity. The study protocol is registered on PROSPERO with reference number: CRD42020213435. Results In this meta-analysis, a total of 27 studies with 45,811 study participants were included. The pooled prevalence of metabolic syndrome was 23.7% with substantial heterogeneity (I2 = 98.2%; P < 0.001). Geographical-based subgroup analysis revealed that the highest prevalence was observed in Australia (27.3%). As per meta-analysis of 17 studies, the pooled prevalence of metabolic syndrome in female type 1 diabetes patients (25.9%) was slightly higher than male T1DM patients (22.5%). Conclusion Nearly a quarter of the type 1 diabetes mellitus patients were affected by metabolic syndrome. Therefore, more attention should be paid to the prevention and control of the epidemic and for the reduction of the morbidity and mortality associated with metabolic syndrome among type 1 diabetes mellitus patients.

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The relation between awareness of personal resources and metabolic control in children and adolescents with type 1 diabetes

Pediatric Diabetes ◽

10.1111/pedi.12177 ◽

2014 ◽

Vol 16 (6) ◽

pp. 454-461 ◽

Cited By ~ 4

Author(s):

Maren Blicke ◽

Ulrike Körner ◽

Patricia Nixon ◽

Burak Salgin ◽

Thomas Meissner ◽

...

Keyword(s):

Type 1 Diabetes ◽

Children And Adolescents ◽

Metabolic Control ◽

Personal Resources

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Faculty Opinions recommendation of Bone Mineral Density and Type 1 Diabetes in Children and Adolescents: A Meta-analysis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.740512255.793588285 ◽

2021 ◽

Author(s):

Madhusmita Misra

Keyword(s):

Bone Mineral Density ◽

Type 1 Diabetes ◽

Children And Adolescents ◽

Bone Mineral ◽

Meta Analysis ◽

Mineral Density

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Association between urinary N-acetyl-beta-glucosaminidase and its isoenzyme patterns and microangiopathy in type 1 diabetes mellitus

Clinical Chemistry ◽

10.1093/clinchem/37.10.1696 ◽

1991 ◽

Vol 37 (10) ◽

pp. 1696-1699 ◽

Cited By ~ 14

Author(s):

C D Agardh ◽

E Agardh ◽

A Isaksson ◽

B Hultberg

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Metabolic Control ◽

Isoenzyme Pattern ◽

Diabetic Patients ◽

Type 1 Diabetic Patients ◽

Isoenzyme Patterns ◽

Apparently Healthy

Abstract Urinary N-acetyl-beta-glucosaminidase (NAG) and its isoenzymes (NAG A and NAG B) in samples from 87 type 1 diabetic patients and 40 apparently healthy reference subjects were studied with enzyme immunoassays. The diabetic patients had higher concentrations of urinary NAG than did the control subjects (P less than 0.01), but the isoenzyme pattern did not differ. There was a positive correlation between metabolic control (Hb A1c concentrations) and total NAG (P less than 0.01), NAG A (P less than 0.01), and NAG B (P less than 0.001). The diabetic patients were divided into three groups, depending on the degree of retinopathy. Subjects with severe forms of retinopathy did not have increased concentrations of urinary NAG unless they had concomitant nephropathy. The isoenzyme pattern was similar irrespective of degree of retinopathy or nephropathy. The results indicate that concentrations of urinary NAG are positively correlated to the degree of nephropathy, whereas there is no such correlation to the degree of retinopathy.

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