Thyroid function is not associated with brown adipose tissue volume and 18F-Fluorodeoxyglucose uptake in young euthyroid adults

2021 ◽  
Author(s):  
Elisa Merchán Ramírez ◽  
Guillermo Sanchez-Delgado ◽  
Cristina Arrizabalaga-Arriazu ◽  
Borja Martinez-Tellez ◽  
Andrea Mendez-Gutierrez ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Thyroid Function ◽  
Cold Exposure ◽  
Thyroid Stimulating Hormone ◽  
Cross Sectional ◽  
Fdg Uptake ◽  
18F Fluorodeoxyglucose ◽  
Brown Adipose ◽  
18F Fdg

Purpose: Thyroid hormones (THs) are important mediators of brown adipose tissue (BAT) differentiation. However, the association of TH concentrations with human BAT is unclear. The present work examines the associations between circulating thyroid-stimulating hormone (TSH) and THs concentrations (i.e. free tri-iodothyronine, FT3, and free thyroxine, FT4), under thermoneutral [22-23ºC] and cold-induced conditions, and BAT volume, 18F-fluorodeoxyglucose (18F-FDG) uptake and mean radiodensity. Methods: A total of 106 young healthy, euthyroid adults (34 men/72 women; 22.0 ± 2.1 years old; 24.9 ± 4.6 kg/m2) participated in this cross-sectional study. BAT volume, 18F-FDG uptake and mean radiodensity were assessed after 2 h of personalized (i.e., contemplating each individual's shivering threshold) cold exposure via positron emission tomography/computerized tomography (PET/CT) static scanning. TSH and THs levels were determined before (thermoneutral) and 1 h after the cold exposure. Results: Cold exposure increased circulating FT4 (P=0.038) and reduced of TSH levels (P≤0.001). Conversely, the FT3 serum concentration was not modified by cold exposure (P=0.435). No associations were found between the TSH and THs thermoneutral (all P>0.289) or cold-induced levels (all P>0.067) and BAT volume,18F-FDG uptake and mean radiodensity. These findings were independent of sex and body mass index. Conclusions: Thyroid function is modulated by cold exposure, yet it is not associated with BAT volume or glucose metabolism assessed after 2h of cold exposure in young healthy, euthyroid adults. 

Determinants of Physiologic 18F-FDG Uptake in Brown Adipose Tissue in Sequential PET/CT Examinations

2010 ◽  
Vol 13 (5) ◽  
pp. 1029-1035 ◽  
Author(s):  
Leonardo Pace ◽  
Emanuele Nicolai ◽  
Domenico D’Amico ◽  
Francesco Ibello ◽  
Anna Maria Della Morte ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Fdg Uptake ◽  
Brown Adipose ◽  
Pet Ct ◽  
18F Fdg

scholarly journals Sleep duration and quality are not associated with brown adipose tissue volume or activity—as determined by 18F-FDG uptake, in young, sedentary adults

SLEEP ◽  
2019 ◽  
Vol 42 (12) ◽  
Author(s):  
Francisco M Acosta ◽  
Guillermo Sanchez-Delgado ◽  
Borja Martinez-Tellez ◽  
Jairo H Migueles ◽  
Francisco J Amaro-Gahete ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Sleep Quality ◽  
Brown Adipose Tissue ◽  
Sleep Duration ◽  
Sleep Disturbances ◽  
Sleep Regulation ◽  
Clinical Trial Registration ◽  
Fdg Uptake ◽  
Brown Adipose ◽  
18F Fdg

Abstract Study Objectives Short sleep duration and sleep disturbances have been related to obesity and metabolic disruption. However, the behavioral and physiological mechanisms linking sleep and alterations in energy balance and metabolism are incompletely understood. In rodents, sleep regulation is closely related to appropriate brown adipose tissue (BAT) thermogenic activity, but whether the same is true in humans has remained unknown. The present work examines whether sleep duration and quality are related to BAT volume and activity (measured by 18F-FDG) and BAT radiodensity in humans. Methods A total of 118 healthy adults (69% women, 21.9 ± 2.2 years, body mass index: 24.9 ± 4.7 kg/m2) participated in this cross-sectional study. Sleep duration and other sleep variables were measured using a wrist-worn accelerometer for seven consecutive days for 24 hours per day. The Pittsburgh Sleep Quality Index was used to assess sleep quality. All participants then underwent a personalized cold exposure to determine their BAT volume, activity, and radiodensity (a proxy of the intracellular triglyceride content), using static positron emission tomography combined with computed tomography (PET/CI) scan. Results Neither sleep duration nor quality was associated with BAT volume or activity (the latter represented by the mean and peak standardized 18F-FDG uptake values) or radiodensity (all p > .1). The lack of association remained after adjusting the analyses for sex, date of PET/CT, and body composition. Conclusions Although experiments in rodent models indicate a strong relationship to exist between sleep regulation and BAT function, it seems that sleep duration and quality may not be directly related to the BAT variables examined in the present work. Clinical Trial Registration NCT02365129 (ClinicalTrials.gov).

scholarly journals Brown adipose tissue volume and 18F-fluorodeoxyglucose uptake are not associated with energy intake in young human adults

2019 ◽  
Vol 111 (2) ◽  
pp. 329-339 ◽  
Author(s):  
Guillermo Sanchez-Delgado ◽  
Francisco M Acosta ◽  
Borja Martinez-Tellez ◽  
Graham Finlayson ◽  
Catherine Gibbons ◽  
...  
Keyword(s):  
Young Adults ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Energy Intake ◽  
Appetite Regulation ◽  
Fdg Uptake ◽  
Brown Adipose ◽  
Ad Libitum ◽  
18F Fdg ◽  
Meal Consumption

ABSTRACT Background Several studies have explored the role of human brown adipose tissue (BAT) in energy expenditure. However, the link between BAT and appetite regulation needs to be more rigorously examined. Objectives We aimed to investigate the associations of BAT volume and 18F-fluordeoxyglucose (18F-FDG) uptake after a personalized cold exposure with energy intake and appetite-related sensations in young healthy humans. Methods A total of 102 young adults (65 women; age: 22.08 ± 2.17 y; BMI: 25.05 ± 4.93 kg/m 2) took part in this cross-sectional study. BAT volume, BAT 18F-FDG uptake, and skeletal muscle 18F-FDG uptake were assessed by means of static 18F-FDG positron-emission tomography and computed tomography scans after a 2-h personalized exposure to cold. Energy intake was estimated via an objectively measured ad libitum meal and three nonconsecutive 24-h dietary recalls. Appetite-related sensations (i.e., hunger and fullness) were recorded by visual analog scales before and after a standardized breakfast (energy content = 50% of basal metabolic rate) and the ad libitum meal. Body composition was assessed by a whole-body DXA scan. Results BAT volume and 18F-FDG uptake were not associated with quantified ad libitum energy intake (all P > 0.088), nor with habitual energy intake estimated from the 24-h dietary recalls (all P  > 0.683). Lean mass was positively associated with both the energy intake from the ad libitum meal (β: 17.612, R2 = 0.213; P < 0.001) and the habitual energy intake (β: 16.052, R2 = 0.123; P = 0.001). Neither the interaction BAT volume × time elapsed after meal consumption nor that of BAT 18F-FDG uptake × time elapsed after meal consumption had any significant influence on appetite-related sensations after breakfast or after meal consumption (all P > 0.3). Conclusions Neither BAT volume, nor BAT 18F-FDG uptake after cold stimulation, are related to appetite regulation in young adults. These results suggest BAT plays no important role in the regulation of energy intake in humans. This trial was registered at clinicaltrials.gov as NCT02365129.

Pre-medication to block [18F]FDG uptake in the brown adipose tissue of pediatric and adolescent patients

2005 ◽  
Vol 35 (10) ◽  
pp. 984-990 ◽  
Author(s):  
Michael J. Gelfand ◽  
Sara M. O’Hara ◽  
Lois A. Curtwright ◽  
Joseph R. MacLean
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Fdg Uptake ◽  
Brown Adipose ◽  
Adolescent Patients ◽  
18F Fdg

scholarly journals Erratum to: Pre-medication to block [18F]FDG uptake in the brown adipose tissue of pediatric and adolescent patients

2011 ◽  
Vol 41 (4) ◽  
pp. 542-542
Author(s):  
Michael J. Gelfand ◽  
Sara M. O’Hara ◽  
Lois A. Curtwright ◽  
Joseph R. MacLean
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Fdg Uptake ◽  
Brown Adipose ◽  
Adolescent Patients ◽  
18F Fdg

scholarly journals Leucine Potentiates Glucose-mediated 18F-FDG Uptake in Brown Adipose Tissue via β-Adrenergic Activation

Biomedicines ◽  
2020 ◽  
Vol 8 (6) ◽  
pp. 159
Author(s):  
Brenda Huska ◽  
Sarah Niccoli ◽  
Christopher P. Phenix ◽  
Simon J. Lees
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Whole Body ◽  
Fdg Uptake ◽  
Standardized Uptake Values ◽  
Positron Emission ◽  
Brown Adipose ◽  
18F Fdg ◽  
Adrenergic Activation

Significant depots of brown adipose tissue (BAT) have been identified in many adult humans through positron emission tomography (PET), with the amount of BAT being inversely correlated with obesity. As dietary activation of BAT has implications for whole body glucose metabolism, leucine was used in the present study to determine its ability to promote BAT activation resulting in increased glucose uptake. In order to assess this, 2-deoxy-2-(fluorine-18)fluoro-d-glucose (18F-FDG) uptake was measured in C57BL/6 mice using microPET after treatment with leucine, glucose, or both in interscapular BAT (IBAT). Pretreatment with propranolol (PRP) was used to determine the role of β-adrenergic activation in glucose and leucine-mediated 18F-FDG uptake. Analysis of maximum standardized uptake values (SUVMAX) determined that glucose administration increased 18F-FDG uptake in IBAT by 25.3%. While leucine did not promote 18F-FDG uptake alone, it did potentiate glucose-mediated 18F-FDG uptake, increasing 18F-FDG uptake in IBAT by 22.5%, compared to glucose alone. Pretreatment with PRP prevented the increase in IBAT 18F-FDG uptake following the combination of glucose and leucine administration. These data suggest that leucine is effective in promoting BAT 18F-FDG uptake through β-adrenergic activation in combination with glucose.

The Presence of Active Brown Adipose Tissue Determines Cold-Induced Energy Expenditure and Oxylipin Profiles in Humans

2020 ◽  
Vol 105 (7) ◽  
pp. 2203-2216 ◽  
Author(s):  
Oana C Kulterer ◽  
Laura Niederstaetter ◽  
Carsten T Herz ◽  
Alexander R Haug ◽  
Andrea Bileck ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Energy Expenditure ◽  
Brown Adipose Tissue ◽  
Cold Exposure ◽  
Fdg Pet ◽  
Brown Adipose ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Abstract Background Accumulating evidence links brown adipose tissue (BAT) to increased cold-induced energy expenditure (CIEE) and regulation of lipid metabolism in humans. BAT has also been proposed as a novel source for biologically active lipid mediators including polyunsaturated fatty acids (PUFAs) and oxylipins. However, little is known about cold-mediated differences in energy expenditure and various lipid species between individuals with detectable BAT positive (BATpos) and those without BAT negative (BATneg). Methods Here we investigated a unique cohort of matched BATpos and BATneg individuals identified by 18F-fluorodeoxyglucose positron emission tomography combined with computed tomography ([18F]-FDG PET/CT). BAT function, CIEE, and circulating oxylipins, were analyzed before and after short-term cold exposure using [18F]-FDG PET/CT, indirect calorimetry, and high-resolution mass spectrometry, respectively. Results We found that active BAT is the major determinant of CIEE since only BATpos individuals experienced significantly increased energy expenditure in response to cold. A single bout of moderate cold exposure resulted in the dissipation of an additional 20 kcal excess energy in BATpos but not in BATneg individuals. The presence of BAT was associated with a unique systemic PUFA and oxylipin profile characterized by increased levels of anti-inflammatory omega-3 fatty acids as well as cytochrome P450 products but decreased concentrations of some proinflammatory hydroxyeicosatetraenoic acids when compared with BATneg individuals. Notably, cold exposure raised circulating levels of various lipids, including the recently identified BAT-derived circulating factors (BATokines) DiHOME and 12-HEPE, only in BATpos individuals. Conclusions In summary, our data emphasize that BAT in humans is a major contributor toward cold-mediated energy dissipation and a critical organ in the regulation of the systemic lipid pool.

Brown adipose tissue 18F-FDG uptake in pediatric PET/CT imaging

2010 ◽  
Vol 41 (6) ◽  
pp. 759-768 ◽  
Author(s):  
Terence S. Hong ◽  
Amer Shammas ◽  
Martin Charron ◽  
Katherine A. Zukotynski ◽  
Laura A. Drubach ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Ct Imaging ◽  
Fdg Uptake ◽  
Brown Adipose ◽  
Pet Ct ◽  
18F Fdg
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