Cellular consequences for insulin signal transduction of the naturally occurring AKT2 p.Glu17Lys mutation

2013 ◽  
pp. 1-1
Author(s):  
Marina Minic ◽  
Nuno Rocha ◽  
Ben Challis ◽  
Matthijs Groeneveld ◽  
Stephen O Rahilly ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Insulin Signal Transduction ◽  
Insulin Signal ◽  
Naturally Occurring

scholarly journals Signal Transducer and Activator of Transcription (Stat)-Induced Stat Inhibitor 1 (Ssi-1)/Suppressor of Cytokine Signaling 1 (Socs1) Inhibits Insulin Signal Transduction Pathway through Modulating Insulin Receptor Substrate 1 (Irs-1) Phosphorylation

2001 ◽  
Vol 193 (2) ◽  
pp. 263-270 ◽  
Author(s):  
Yoshinori Kawazoe ◽  
Tetsuji Naka ◽  
Minoru Fujimoto ◽  
Hidetsugu Kohzaki ◽  
Yoshiaki Morita ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Negative Feedback ◽  
Signal Transduction Pathway ◽  
Cytokine Signaling ◽  
Insulin Receptor Substrate ◽  
Signal Transducer ◽  
Transduction Pathway ◽  
Insulin Signal Transduction ◽  
Insulin Signal ◽  
Insulin Signal Transduction Pathway

Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1) is known to function as a negative feedback regulator of cytokine signaling, but it is unclear whether it is involved in other biological events. Here, we show that SSI-1 participates and plays an important role in the insulin signal transduction pathway. SSI-1–deficient mice showed a significantly low level of blood sugar. While the forced expression of SSI-1 reduced the phosphorylation level of insulin receptor substrate 1 (IRS-1), SSI-1 deficiency resulted in sustained phosphorylation of IRS-1 in response to insulin. Furthermore, SSI-1 achieves this inhibition both by binding directly to IRS-1 and by suppressing Janus kinases. These findings suggest that SSI-1 acts as a negative feedback factor also in the insulin signal transduction pathway through the suppression of IRS-1 phosphorylation.

Effect of chronic growth hormone treatment on insulin signal transduction in rat tissues

1997 ◽  
Vol 130 (1-2) ◽  
pp. 33-42 ◽  
Author(s):  
Ana C.P Thirone ◽  
Carla R.O Carvalho ◽  
Sigisfredo L Brenelli ◽  
Lı́cio A Velloso ◽  
Mario J.A. Saad
Keyword(s):  
Signal Transduction ◽  
Growth Hormone ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Rat Tissues ◽  
Insulin Signal Transduction ◽  
Insulin Signal

scholarly journals Insulin Signal Transduction by a Mutant Human Insulin Receptor Lacking the NPEY Sequence

1997 ◽  
Vol 272 (36) ◽  
pp. 22884-22890 ◽  
Author(s):  
Paulos Berhanu ◽  
Celia Anderson ◽  
Matt Hickman ◽  
Theodore P. Ciaraldi
Keyword(s):  
Signal Transduction ◽  
Insulin Receptor ◽  
Human Insulin ◽  
Insulin Signal Transduction ◽  
Insulin Signal ◽  
Human Insulin Receptor

scholarly journals Insulin signal transduction and glucose transport in human adipocytes: effects of obesity and low calorie diet

Diabetologia ◽  
2002 ◽  
Vol 45 (8) ◽  
pp. 1128-1135 ◽  
Author(s):  
Björnholm M. ◽  
Al-Khalili L. ◽  
Dicker A. ◽  
Näslund E. ◽  
Rössner S. ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Glucose Transport ◽  
Human Adipocytes ◽  
Low Calorie ◽  
Insulin Signal Transduction ◽  
Insulin Signal ◽  
Low Calorie Diet ◽  
Calorie Diet

Muscle fiber type-specific defects in insulin signal transduction to glucose transport in diabetic GK rats

Diabetes ◽  
1999 ◽  
Vol 48 (3) ◽  
pp. 664-670 ◽  
Author(s):  
X. M. Song ◽  
Y. Kawano ◽  
A. Krook ◽  
J. W. Ryder ◽  
S. Efendic ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Glucose Transport ◽  
Muscle Fiber ◽  
Fiber Type ◽  
Muscle Fiber Type ◽  
Insulin Signal Transduction ◽  
Insulin Signal ◽  
Gk Rats
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