Thyroid dysfunction in type 2 diabetic patients

Background: Diabetes mellitus is a very common endocrinal disorders and incidence of thyroid dysfunction also rising in India and world over. Thyroid hormones directly control insulin secretion and insulin clearance. Diabetes also may affect the thyroid function to variable extent first at the level of hypothalamic control of TSH release and second at peripheral tissue by converting T4 to T3. Aims and Objectives: The present study was carried out aiming to evaluate thyroid dysfunction among type 2 diabetes mellitus patients. Material and Methods: Study included total 80 subjects. Thyroid dysfunction was evaluated by investigating the subjects for Total tri-iodo-thyronine (T3), Total thyroxine (T4) and thyroid stimulating hormone (TSH). Plasma glucose was estimated by- GOD-POD method and Thyroid profile was estimated by- CLIA (chemiluminescence immunoassay) system. Statistical analysis was performed using software statistical package for social sciences (SPSS) version 20, unpaired T test, Pearson’s correlation. Results: In type 2 diabetic patients the prevalence of hypothyroidism and subclinical hypothyroidism was found to be 4(10.00%) and 6(15.00%) respectively, while the prevalence of subclinical hyperthyroidism and hyperthyroidism was found to be 0(0.0%) and 1(2.5%) respectively. In non diabetic healthy subjects the prevalence of hypothyroidism and subclinical hypothyroidism was found to be 1(2.5%) and 3(7.5%) respectively while the prevalence of subclinical hyperthyroidism and hyperthyroidism was found to be 0(0.0%) and 0(0.0%) respectively. Conclusion: The prevalence of thyroid dysfunction was found to be higher in type 2 diabetes mellitus subjects as compared to non-diabetic subjects. DOI: http://dx.doi.org/10.3126/ajms.v6i3.10814Asian Journal of Medical Sciences Vol.6(3) 2015 33-37

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Study of Thyroid Function Status in Type 2 Diabetic Patients

KYAMC Journal ◽

10.3329/kyamcj.v10i2.42787 ◽

2019 ◽

Vol 10 (2) ◽

pp. 95-98

Author(s):

Kamrunnahar Alo ◽

Shyamal Chandra Banik ◽

Safayet Ahammed ◽

Ayesha Yasmin ◽

Tania Rahman

Keyword(s):

Thyroid Function ◽

Thyroid Dysfunction ◽

Cross Sectional Study ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Cross Sectional ◽

Medical College ◽

The Difference ◽

Type 2 Diabetic

Background: Thyroid dysfunction specially hypothyroidism may occur in type 2 diabetic patients. Objective: To observe thyroid function status in type 2 diabetic patients Materials and Methods: This cross sectional study was carried out in the Department of Physiology, Sir Salimullah Medical College, Dhaka from July 2016 to June 2017. Total 60 subjects including male and female, age ranged from 40 to 60 years were included in this study, among them 30 were non-diabetic subjects and 30 were type 2 diabetic patients. Results: In this study, mean serum TSH level was significantly (p<0.001) higher and serum FT4 level was significantly (p<0.01) lower in diabetic patients than that of apparently healthy non-diabetic subjects. Serum FT3 level was lower in type 2 diabetic patients in comparison to that of non-diabetic subjects but the difference was not statistically significant. However, among the diabetic patients 10% were subclinical hypothyroid and 6.67% were hypothyroid Conclusion: The present study reveals that hypothyroidism occurs in type 2 diabetic patients. So type 2 diabetic patients should measure thyroid hormone levels routinely to detect thyroid dysfunction. KYAMC Journal Vol. 10, No.-2, July 2019, Page 95-98

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Prevalence and Predictors of Thyroid Dysfunction Among Type 2 Diabetic Patients: A Case–Control Study

International Journal of General Medicine ◽

10.2147/ijgm.s273900 ◽

2020 ◽

Vol Volume 13 ◽

pp. 803-816

Author(s):

Adi H Khassawneh ◽

Abdel-Hameed Al-Mistarehi ◽

Anas M Zein Alaabdin ◽

Laith Khasawneh ◽

Thekraiat M AlQuran ◽

...

Keyword(s):

Thyroid Dysfunction ◽

Case Control Study ◽

Case Control ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Type 2 Diabetic ◽

Control Study

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Risk Factors for Thyroid Dysfunction among Type 2 Diabetic Patients in a Highly Diabetes Mellitus Prevalent Society

International Journal of Endocrinology ◽

10.1155/2013/417920 ◽

2013 ◽

Vol 2013 ◽

pp. 1-6 ◽

Cited By ~ 15

Author(s):

Metab Al-Geffari ◽

Najlaa A. Ahmad ◽

Ahmad H. Al-Sharqawi ◽

Amira M. Youssef ◽

Dhekra AlNaqeb ◽

...

Keyword(s):

Risk Factors ◽

Thyroid Dysfunction ◽

Female Gender ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Different Types ◽

History Of ◽

Type 2 Diabetic ◽

Saudi Patients

Diabetes and thyroid dysfunction found to exist simultaneously. In this regard, the present study looked into the prevalence of different forms of thyroid dysfunction and their risk factors among Type 2 diabetic Saudi patients.Methodology. A cross-sectional retrospective randomized hospital-based study of 411 Type 2 diabetic Saudi patients of >25 years of age was conducted to test the prevalence of different types of thyroid dysfunction and their risk factors.Results. The prevalence of different types of thyroid dysfunction is 28.5%, of which 25.3% had hypothyroidism, where 15.3%, 9.5%, and 0.5% are clinical, subclinical, and overt hypothyroidism, respectively. The prevalence of hyperthyroidism is 3.2%, of which subclinical cases accounted for 2.7% and overt hyperthyroidism accounted for 0.5%. Risk factors for thyroid dysfunction among Saudi Type 2 diabetic patients are family history of thyroid disease, female gender, and duration of diabetes of >10 years, while the risk was not significant in patients with history of goiter and patients aged >60 years. Smoking and parity show a nonsignificant reduced risk.Conclusion. Thyroid dysfunction is highly prevalent among Saudi Type 2 diabetic patients, and the most significant risk factors are family history of thyroid disease, female gender, and >10 years duration of diabetes.

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