Prevalence of thyroid dysfunction among type 2 diabetic patients attending the Diabetes Clinic, National Hospital of Sri Lanka

Background: Diabetes mellitus is a very common endocrinal disorders and incidence of thyroid dysfunction also rising in India and world over. Thyroid hormones directly control insulin secretion and insulin clearance. Diabetes also may affect the thyroid function to variable extent first at the level of hypothalamic control of TSH release and second at peripheral tissue by converting T4 to T3. Aims and Objectives: The present study was carried out aiming to evaluate thyroid dysfunction among type 2 diabetes mellitus patients. Material and Methods: Study included total 80 subjects. Thyroid dysfunction was evaluated by investigating the subjects for Total tri-iodo-thyronine (T3), Total thyroxine (T4) and thyroid stimulating hormone (TSH). Plasma glucose was estimated by- GOD-POD method and Thyroid profile was estimated by- CLIA (chemiluminescence immunoassay) system. Statistical analysis was performed using software statistical package for social sciences (SPSS) version 20, unpaired T test, Pearson’s correlation. Results: In type 2 diabetic patients the prevalence of hypothyroidism and subclinical hypothyroidism was found to be 4(10.00%) and 6(15.00%) respectively, while the prevalence of subclinical hyperthyroidism and hyperthyroidism was found to be 0(0.0%) and 1(2.5%) respectively. In non diabetic healthy subjects the prevalence of hypothyroidism and subclinical hypothyroidism was found to be 1(2.5%) and 3(7.5%) respectively while the prevalence of subclinical hyperthyroidism and hyperthyroidism was found to be 0(0.0%) and 0(0.0%) respectively. Conclusion: The prevalence of thyroid dysfunction was found to be higher in type 2 diabetes mellitus subjects as compared to non-diabetic subjects. DOI: http://dx.doi.org/10.3126/ajms.v6i3.10814Asian Journal of Medical Sciences Vol.6(3) 2015 33-37

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Study of Thyroid Function Status in Type 2 Diabetic Patients

KYAMC Journal ◽

10.3329/kyamcj.v10i2.42787 ◽

2019 ◽

Vol 10 (2) ◽

pp. 95-98

Author(s):

Kamrunnahar Alo ◽

Shyamal Chandra Banik ◽

Safayet Ahammed ◽

Ayesha Yasmin ◽

Tania Rahman

Keyword(s):

Thyroid Function ◽

Thyroid Dysfunction ◽

Cross Sectional Study ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Cross Sectional ◽

Medical College ◽

The Difference ◽

Type 2 Diabetic

Background: Thyroid dysfunction specially hypothyroidism may occur in type 2 diabetic patients. Objective: To observe thyroid function status in type 2 diabetic patients Materials and Methods: This cross sectional study was carried out in the Department of Physiology, Sir Salimullah Medical College, Dhaka from July 2016 to June 2017. Total 60 subjects including male and female, age ranged from 40 to 60 years were included in this study, among them 30 were non-diabetic subjects and 30 were type 2 diabetic patients. Results: In this study, mean serum TSH level was significantly (p<0.001) higher and serum FT4 level was significantly (p<0.01) lower in diabetic patients than that of apparently healthy non-diabetic subjects. Serum FT3 level was lower in type 2 diabetic patients in comparison to that of non-diabetic subjects but the difference was not statistically significant. However, among the diabetic patients 10% were subclinical hypothyroid and 6.67% were hypothyroid Conclusion: The present study reveals that hypothyroidism occurs in type 2 diabetic patients. So type 2 diabetic patients should measure thyroid hormone levels routinely to detect thyroid dysfunction. KYAMC Journal Vol. 10, No.-2, July 2019, Page 95-98

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Variability in the presence of the metabolic syndrome in Type 2 diabetic patients attending a diabetes clinic

Diabetes Research and Clinical Practice ◽

10.1016/j.diabres.2003.12.003 ◽

2004 ◽

Vol 65 (2) ◽

pp. 135-142 ◽

Cited By ~ 13

Author(s):

F Relimpio ◽

M.A Martinez-Brocca ◽

A Leal-Cerro ◽

F Losada ◽

M.A Mangas ◽

...

Keyword(s):

Metabolic Syndrome ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Diabetes Clinic ◽

The Metabolic Syndrome ◽

Type 2 Diabetic

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Prevalence and Predictors of Thyroid Dysfunction Among Type 2 Diabetic Patients: A Case–Control Study

International Journal of General Medicine ◽

10.2147/ijgm.s273900 ◽

2020 ◽

Vol Volume 13 ◽

pp. 803-816

Author(s):

Adi H Khassawneh ◽

Abdel-Hameed Al-Mistarehi ◽

Anas M Zein Alaabdin ◽

Laith Khasawneh ◽

Thekraiat M AlQuran ◽

...

Keyword(s):

Thyroid Dysfunction ◽

Case Control Study ◽

Case Control ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Type 2 Diabetic ◽

Control Study

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Cardiovascular Risk Profile of Type 2 Diabetic Patients Cared for by General Practitioners or at a Diabetes Clinic

Journal of Clinical Epidemiology ◽

10.1016/s0895-4356(99)00002-5 ◽

1999 ◽

Vol 52 (5) ◽

pp. 413-417 ◽

Cited By ~ 12

Author(s):

Graziella Bruno ◽

Paolo Cavallo-Perin ◽

Giuseppe Bargero ◽

Milena Borra ◽

Nicola D’Errico ◽

...

Keyword(s):

Cardiovascular Risk ◽

General Practitioners ◽

Risk Profile ◽

Diabetic Patients ◽

Cardiovascular Risk Profile ◽

Type 2 Diabetic Patients ◽

Diabetes Clinic ◽

Type 2 Diabetic

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Risk Factors for Thyroid Dysfunction among Type 2 Diabetic Patients in a Highly Diabetes Mellitus Prevalent Society

International Journal of Endocrinology ◽

10.1155/2013/417920 ◽

2013 ◽

Vol 2013 ◽

pp. 1-6 ◽

Cited By ~ 15

Author(s):

Metab Al-Geffari ◽

Najlaa A. Ahmad ◽

Ahmad H. Al-Sharqawi ◽

Amira M. Youssef ◽

Dhekra AlNaqeb ◽

...

Keyword(s):

Risk Factors ◽

Thyroid Dysfunction ◽

Female Gender ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Different Types ◽

History Of ◽

Type 2 Diabetic ◽

Saudi Patients

Diabetes and thyroid dysfunction found to exist simultaneously. In this regard, the present study looked into the prevalence of different forms of thyroid dysfunction and their risk factors among Type 2 diabetic Saudi patients.Methodology. A cross-sectional retrospective randomized hospital-based study of 411 Type 2 diabetic Saudi patients of >25 years of age was conducted to test the prevalence of different types of thyroid dysfunction and their risk factors.Results. The prevalence of different types of thyroid dysfunction is 28.5%, of which 25.3% had hypothyroidism, where 15.3%, 9.5%, and 0.5% are clinical, subclinical, and overt hypothyroidism, respectively. The prevalence of hyperthyroidism is 3.2%, of which subclinical cases accounted for 2.7% and overt hyperthyroidism accounted for 0.5%. Risk factors for thyroid dysfunction among Saudi Type 2 diabetic patients are family history of thyroid disease, female gender, and duration of diabetes of >10 years, while the risk was not significant in patients with history of goiter and patients aged >60 years. Smoking and parity show a nonsignificant reduced risk.Conclusion. Thyroid dysfunction is highly prevalent among Saudi Type 2 diabetic patients, and the most significant risk factors are family history of thyroid disease, female gender, and >10 years duration of diabetes.

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Thyroid dysfunction among Greek type 1 and type 2 diabetic patients attending an outpatient clinic

Endocrine Abstracts ◽

10.1530/endoabs.41.ep436 ◽

2016 ◽

Author(s):

Maria Barmpari ◽

Maria Kokkorou ◽

Anastasia Micheli ◽

Irene Alexiou ◽

Elefteria Spanou ◽

...

Keyword(s):

Outpatient Clinic ◽

Thyroid Dysfunction ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Type 2 Diabetic

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Prevalence of Thyroid Dysfunction Among Greek Type 2 Diabetic Patients Attending an Outpatient Clinic

Journal of Clinical Medicine Research ◽

10.4021/jocmr2010.03.281w ◽

2010 ◽

Cited By ~ 14

Author(s):

Athanasia Papazafiropoulou

Keyword(s):

Outpatient Clinic ◽

Thyroid Dysfunction ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Type 2 Diabetic

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Mortality outcomes of different sulphonylurea drugs: the results of a 14-year cohort study of type 2 diabetic patients

Acta Endocrinologica ◽

10.1530/eje-13-0299 ◽

2013 ◽

Vol 169 (1) ◽

pp. 117-126 ◽

Cited By ~ 22

Author(s):

Simona Bo ◽

Anna Castiglione ◽

Ezio Ghigo ◽

Luigi Gentile ◽

Marilena Durazzo ◽

...

Keyword(s):

Cancer Mortality ◽

Diabetic Patients ◽

Diabetes Diagnosis ◽

Type 2 Diabetic Patients ◽

Diabetes Clinic ◽

Specific Mortality ◽

Clinical Records ◽

Type 2 Diabetic

ObjectiveAvailable data about mortality of type 2 diabetic patients treated with different sulphonylureas are scarce and contradictory.DesignWe evaluated the associations between all-cause and cause-specific mortality and treatments with different sulphonylureas in a retrospective cohort of type 2 diabetic patients from a diabetes clinic.MethodsAll 1277 patients treated with sulphonylureas during 1996–1997 were enrolled: 159 patients were treated with tolbutamide, 977 glibenclamide and 141 gliclazide. The baseline data (centralised laboratory parameters, anthropometric data and presence of chronic complications) were abstracted from the clinical records. Information on vital status was collected from demographic files after 14-year follow-up. Adjusted hazard ratios (HR) were estimated with Cox (all-cause mortality) or Fine and Gray models (cause-specific mortality), including several potential confounders.ResultsFive hundred and fifty-six patients died during the follow-up: 262 from cardiovascular causes, 158 from cancer and 136 from other causes. When compared with the glibenclamide users, the gliclazide and tolbutamide users showed a significantly lower cancer mortality (HR=0.30; 95% CI 0.16–0.55, and HR=0.48; 95% CI 0.29–0.79 respectively). These results were strongly confirmed in the 555 patients on sulphonylurea monotherapy. None of the patients who were treated with gliclazide monotherapy died from cancer during the follow-up, and the patients on tolbutamide treatment exhibited a lower cancer mortality than the glibenclamide users (HR=0.40; 95% CI 0.22–0.71). Data did not change after stratification for the duration of sulphonylurea treatment from diabetes diagnosis to the study enrolment.ConclusionsCancer mortality was markedly reduced in the patients on gliclazide and tolbutamide treatment. These results suggest additional benefits for these drugs beyond their blood glucose-lowering effect and strongly advocate for further investigation.

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