scholarly journals Can ratio of primary tumor diameter to total tumor diameter be a new parameter in the differential diagnosis of agressive and favorable multifocal papillary thyroid microcarcinoma?

2016 ◽  
Author(s):  
Tam Abbas Ali ◽  
Didem Ozdemir ◽  
Neslihan Cuhaci ◽  
Husniye Baser ◽  
Ahmet Dirikoc ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Primary Tumor ◽  
Papillary Thyroid Microcarcinoma ◽  
Tumor Diameter ◽  
Papillary Thyroid ◽  
Thyroid Microcarcinoma

scholarly journals Analysis of risk factors for cervical lymph node metastasis of papillary thyroid microcarcinoma: a study of 268 patients

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Jian-hua Gu ◽  
Yan-na Zhao ◽  
Rong-li Xie ◽  
Wen-juan Xu ◽  
Da-li You ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lymph Node ◽  
Multivariate Regression ◽  
Cervical Lymph Node ◽  
Cervical Lymph Node Metastasis ◽  
Papillary Thyroid Microcarcinoma ◽  
Tumor Diameter ◽  
Papillary Thyroid ◽  
Thyroid Microcarcinoma ◽  
Male Sex

Abstract Background To investigate the risk factors of cervical lymph node (LN) metastasis in papillary thyroid microcarcinoma (PTMC) patients. Methods We retrospectively analyzed the clinicopathologic data of all patients who received standard lobectomy for PTMC at our institution between October 2017 and January 2019. Central LNs were dissected in all patients. Lateral LNs were dissected if metastasis to the lateral LNs was suggested based on pre-op fine-needle aspiration biopsy. The relationship between variables available prior to surgery and cervical LN metastasis was examined using multivariate regression. Results Post-op pathologic examination revealed cervical LN metastasis in 79 (29.5%) patients. Seventy subjects had metastasis only to central LNs, and 4 (1.5%) patients had metastasis only to lateral LNs. Five patients had metastasis to both central and lateral LNs. In comparison to patients without cervical LN metastasis, those with LN metastasis were significantly younger (40.63 ± 13.07 vs. 44.52 ± 12.23 years; P = 0.021) and had significantly larger tumor diameter on pathology (6.7 ± 2.2 vs. 5.9 ± 2.4 mm; P = 0.010). Multivariate regression analysis identified the following independent risks for cervical LN metastasis: male sex (OR 2.362, 95%CI 1.261~4.425; P = 0.007), age (OR 0.977, 95%CI 0.956~0.999; P = 0.042) and ultrasound tumor diameter at > 5 mm (OR 3.172, 95%CI 1.389~7.240; P = 0.006). Conclusion Cervical LN metastasis occurs in a non-insignificant proportion of PTMC patients. Independent risks included male sex, younger age and larger tumor diameter on ultrasound.

Total tumor diameter: the neglected value in papillary thyroid microcarcinoma

2019 ◽  
Vol 43 (5) ◽  
pp. 601-613 ◽  
Author(s):  
J.-W. Feng ◽  
H. Pan ◽  
L. Wang ◽  
J. Ye ◽  
Y. Jiang ◽  
...  
Keyword(s):  
Papillary Thyroid Microcarcinoma ◽  
Tumor Diameter ◽  
Papillary Thyroid ◽  
Thyroid Microcarcinoma

MULTIFOCAL PAPILLARY THYROID MICROCARCINOMA WITH A TOTAL TUMOR DIAMETER> 1 CM INDICATE POOR BIOLOGICAL BEHAVIOR? - THE EVIDENCE IS INSUFFICIENT

2020 ◽  
Author(s):  
Bin Zhou ◽  
Lin Wei ◽  
Jianwu Qin
Keyword(s):  
Lymph Node ◽  
Biological Behavior ◽  
Papillary Thyroid Microcarcinoma ◽  
Tumor Diameter ◽  
Capsular Invasion ◽  
Papillary Thyroid ◽  
Central Lymph Node ◽  
Node Metastasis ◽  
Thyroid Microcarcinoma ◽  
Central Lymph

Objective: Multifocal cancer is not uncommon in papillary thyroid microcarcinoma (PTMC) . Our aim was to investigate the correlation between multifocal PTMC, total tumor diameter (TTD) and clinicopathological features. Methods: In total, 206 patients were included and grouped as stage cT1a or cT1b. The primary tumor diameter (PTD) and TTD (the sum of the maximal diameter of each focus) were calculated. These patients were further subgrouped as TTD ≤1 cm or 1 cm<TTD ≤2 cm. The relationships of clinicopathological features between these groups were analyzed. Results: Multifocal cancer was more likely to occur with stage cT1a than stage cT1b (p=0.028). Stage cT1b PTC was more prone to central lymph node metastasis (CLNM) (p=0.001) and capsular invasion (p<0.001) than stage cT1a. There was no difference in clinicopathological factors, such as sex (p=0.448), age (p=0.227), CLNM (p=0.739), number of CLNMs (p=0.142), capsular invasion (p=0.804), BRAF mutation (p=0.905) or recurrence (p=0.789), between the multifocal PTMC and TTD>1 cm and PTD+ TTD≤1 cm groups. For the comparison of stage cT1a and cT1b tumors with a 1 cm<TTD≤2 cm, the multivariate analysis, stage cT1b tumors were more prone to capsular invasion than stage cT1a tumors (p=0.006), with an OR of 19.013 (95% CI: 2.295-157.478), but there was no significant correlation with CLNM. Conclusions: Tumors in stage cT1b are more prone to capsular invasion and CLNM than those in stage cT1a. For multifocal PTMC, calculating the TTD to evaluate adverse biological behavior is insufficient and limited, and further research is needed. Abbreviations: PTC = Papillary thyroid carcinoma; PTMC = Papillary thyroid microcarcinoma ; ETE = Extrathyroidal extension; ATA = American Thyroid Association; CLNM = Central lymph node metastasis; TTD = Total tumor diameter; CLND = Central lymph node dissection; DTC =Differentiated thyroid carcinoma ; US = Ultrasound; CT = Computed tomography; PTD = Primary tumor diameter ; Tg = Thyroglobulin ; Anti-Tg = Anti-thyroglobulin antibody ; FNA = Fine needle aspiration; SD = Standard deviation; OR = Odds ratio; CI = Confidence interval.

Clinical Characteristics of Papillary Thyroid Microcarcinoma

2010 ◽  
Vol 53 (3) ◽  
pp. 166 ◽  
Author(s):  
Jae Won Kim ◽  
Dong Youl Lee ◽  
Young Up Cho ◽  
Chang Hyo Kim ◽  
Yoon Suk Oh ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Papillary Thyroid Microcarcinoma ◽  
Papillary Thyroid ◽  
Thyroid Microcarcinoma
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