Strength training results in reduced fat accumulation and improved blood lipid profile even in the absence of skeletal muscle hypertrophy in obese rats induced by high-fat diet

2018 ◽  
Author(s):  
Catarina Contreiro ◽  
Andressa Damiani ◽  
Leonardo Caldas ◽  
Breno Nogueira ◽  
Andre Leopoldo ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Lipid Profile ◽  
High Fat Diet ◽  
Muscle Hypertrophy ◽  
Blood Lipid ◽  
High Fat ◽  
Blood Lipid Profile ◽  
Reduced Fat ◽  
Skeletal Muscle Hypertrophy ◽  
Obese Rats

scholarly journals Olive Oil, Palm Oil, and Hybrid Palm Oil Distinctly Modulate Liver Transcriptome and Induce NAFLD in Mice Fed a High-Fat Diet

2018 ◽  
Vol 20 (1) ◽  
pp. 8 ◽  
Author(s):  
Rafael Sales ◽  
Priscylla Medeiros ◽  
Flavia Spreafico ◽  
Patrícia de Velasco ◽  
Fernanda Gonçalves ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Palm Oil ◽  
High Fat Diet ◽  
Protein Localization ◽  
Blood Lipid ◽  
Liver Fat ◽  
High Fat ◽  
Blood Lipid Profile ◽  
High Fat Diets ◽  
Fat Diets

Nonalcoholic fatty liver disease (NAFLD) is highly prevalent worldwide. The most severe form is nonalcoholic steatohepatitis (NASH). Among risk factors for the development of NAFLD is excessive lipid intake. Since palm (P) oil is the most consumed oil in the world, we aimed to investigate the effects of high-fat diets made with P oil, hybrid palm (HP) oil, or olive (O) oil in liver. Twenty-four male mice (C57Bl/6J) were fed a high-fat diet (41% fat) containing P, HP, or O oils for 8 weeks and compared to a control (C) group fed a chow diet. Adiposity was measured with computed tomography. Body, adipose tissue, and liver weights, as well as liver fat (Bligh–Dyer), blood lipid profile, glucose, and liver enzymes were measured. Liver histology (hematoxylin–eosin) and transcriptome (microarray-based) were performed. ANOVA tests with Newman–Keuls were used. Body weight was increased in the P group (p < 0.001) and body fat in the O group (C vs. O p ≤ 0.01, P vs. O p ≤ 0.05, HP vs. O p ≤ 0.05). All high-fat diets disturbed the blood lipid profile and glucose, with marked effects of HP on very low-density lipoprotein cholesterol (VLDL), triglycerides, and alkaline phosphatase (p ≤ 0.001). HP had the highest liver fat (42.76 ± 1.58), followed by P (33.94 ± 1.13). O had a fat amount comparable to C (16.46 ± 0.34, 14.71 ± 0.70, respectively). P and HP oils induced hepatocyte ballooning. Transcriptome alterations of the O group were related to amino acid metabolism and fatty acid (FA) metabolism, the P group to calcium ion homeostasis, and HP oil to protein localization. Both P and HP oils induced NASH in mice via disturbed hepatocyte transcription. This raises concerns about the content of these oils in several industrialized foods.

scholarly journals Strength Training Reduces Fat Accumulation and Improves Blood Lipid Profile Even in the Absence of Skeletal Muscle Hypertrophy in High-Fat Diet-Induced Obese Condition

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Catarina Denise Entringer Contreiro ◽  
Leonardo Carvalho Caldas ◽  
Breno Valentim Nogueira ◽  
André Soares Leopoldo ◽  
Ana Paula Lima-Leopoldo ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Body Composition ◽  
Strength Training ◽  
High Fat Diet ◽  
Muscle Hypertrophy ◽  
The Body ◽  
High Fat ◽  
Metabolic Adaptations ◽  
Obese Rats ◽  
Training Protocol

The aim was to investigate the effect of strength training on skeletal muscle morphology and metabolic adaptations in obese rats fed with unsaturated high-fat diet (HFD). The hypothesis was that strength training induces positive metabolic adaptations in obese rats despite impaired muscle hypertrophy. Male Wistar rats (n = 58) were randomized into two groups and fed a standard diet or a high-fat diet (HFD) containing 49.2% of fat. After induction and maintenance to obesity, the rats were divided into four groups: animals distributed in sedentary control (CS), control submitted to strength training protocol (CT), obese sedentary (ObS), and obese submitted to strength training protocol (ObT). The exercise protocol consisted of 10 weeks of training on a vertical ladder (three times a week) with a load attached to the animal’s tail. At the end of 10 weeks, strength training promoted positive changes in the body composition and metabolic parameters in obese animals. Specifically, ObT animals presented a reduction of 22.6% and 14.3% in body fat and adiposity index when compared to ObS, respectively. Furthermore, these rats had lower levels of triglycerides (ObT = 23.1 ± 9.5 vs. ObS = 30.4 ± 6.9 mg/dL) and leptin (ObT = 13.2 ± 7.2 vs. ObS = 20.5 ± 4.3 ng/mL). Training (ObT and CT) induced a greater strength gain when compared with the respective control groups. In addition, the weight of the flexor hallucis longus (FHL) muscle was higher in the ObT group than in the CT group, representing an increase of 26.1%. However, training did not promote hypertrophy as observed by a similar cross-sectional area of the FHL and plantar muscles. Based on these results, high-intensity strength training promoted an improvement of body composition and metabolic profile in obese rats that were fed a high-fat diet without skeletal muscle adaptations, becoming a relevant complementary strategy for the treatment of obesity.

Anti-obesity action of gingerol: effect on lipid profile, insulin, leptin, amylase and lipase in male obese rats induced by a high-fat diet

2014 ◽  
Vol 94 (14) ◽  
pp. 2972-2977 ◽  
Author(s):  
Ganapathy Saravanan ◽  
Ponnusamy Ponmurugan ◽  
Machampalayam Arumugam Deepa ◽  
Balasubramanian Senthilkumar
Keyword(s):  
Lipid Profile ◽  
High Fat Diet ◽  
High Fat ◽  
Obese Rats

Lipid profile lowering effect of SoyproTMfermented with lactic acid bacteria isolated from Kimchi in high-fat diet-induced obese rats

BioFactors ◽  
2008 ◽  
Vol 33 (1) ◽  
pp. 49-60 ◽  
Author(s):  
Na-Hyung Kim ◽  
Hyung-Min Kim ◽  
Hyo-Jin An ◽  
Jae-Young Um ◽  
Phil-Dong Moon ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Lipid Profile ◽  
High Fat Diet ◽  
High Fat ◽  
Lowering Effect ◽  
Obese Rats

scholarly journals Erchen Decoction Mitigates Lipid Metabolism Disorder by the Regulation of PPARγ and LPL Gene in a High-Fat Diet C57BL/6 Mice Model

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Mengting Zhang ◽  
Yanfei Shao ◽  
Bizhen Gao ◽  
Jicheng Chen ◽  
Ping Zhang ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Body Weight ◽  
Lipid Metabolism ◽  
Visceral Fat ◽  
Protein Level ◽  
High Fat Diet ◽  
Blood Lipid ◽  
Abdominal Circumference ◽  
High Fat ◽  
Gene And Protein Expression

Erchen decoction (ECD) is a common treatment prescribed in traditional Chinese medicine (TCM) clinics, which has remarkable efficacy in the treatment of obesity, fatty liver, hyperlipidemia, diabetes, and other diseases caused by phlegm. In this study, we investigated the effect that ECD had on the lipid metabolism induced by high-fat diet in C57BL/6 mice. Body weight, body length, and abdominal circumference were detected. Blood lipid content was measured via biochemical assay kit. The gene and protein expression of PPARγ and LPL in visceral fat and skeletal muscle of mice was measured by real-time PCR and western blot. The research discovered that the phlegm-resolving effect that ECD had on high-fat diet mice was mainly manifested as reduced body weight, Lee’s index, abdominal circumference, and level of TG and TC. Meanwhile, we observed significantly increased PPARγ mRNA and protein level in visceral fat and PPARγ and LPL protein level in skeletal muscle in the ECD group. Contrarily, a decrease in PPARγ mRNA level in skeletal muscle in the ECD group was observed. Therefore, we speculate that ECD regulates the lipid metabolic disorder by decreasing the blood lipid level. Moreover, the potential molecular mechanism of ECD is to promote the expression of PPARγ in visceral fat and skeletal muscle and the expression of LPL in skeletal muscle.

Impaired Insulin Resistance in IF1-Deficient Mice Subjected to a High-Fat Diet with Reduced-Fat Mass and Skeletal Muscle Lipid Accumulation

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1748-P ◽  
Author(s):  
FENGYUAN HUANG ◽  
KEVIN YANG ◽  
KAMALAMMA SAJA ◽  
YICHENG HUANG ◽  
QINGQIANG LONG ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Lipid Accumulation ◽  
High Fat Diet ◽  
High Fat ◽  
Muscle Lipid ◽  
Reduced Fat ◽  
Impaired Insulin ◽  
Skeletal Muscle Lipid ◽  
Deficient Mice
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