Autoimmune thyroiditis and repeated pregnancy loss: a role for associated autoimmune disorders?

Chromosome analyses in couples with repeated pregnancy loss

Journal of Biosocial Science ◽

10.1017/s0021932000013845 ◽

1982 ◽

Vol 14 (1) ◽

pp. 33-52 ◽

Cited By ~ 2

Author(s):

T. Andrews ◽

D. F. Roberts

Keyword(s):

Pregnancy Loss ◽

Abnormal Karyotype ◽

Control Series ◽

Chromosome Anomalies ◽

Reproductive Loss ◽

Obvious Reason ◽

Repeated Pregnancy Loss

SummaryCytogenetic investigations were undertaken on 120 couples in Newcastle with repeated pregnancy loss for which no anatomical or other obvious reason could be established. The level of major chromosome anomalies was high, with 6·7% of couples showing one member with an abnormal karyotype. One major anomaly occurred in a control series of 240 random newborns. The couples also showed an elevated incidence of chromosomal heteromorphisms. Similar studies in the literature are reviewed. It seems that major chromosome anomalies make an appreciable contribution to repeated reproductive loss, but proof of the involvement of minor chromosome variants though suspected is less clear.

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No mitochondrial DNA deletions but more D-loop point mutations in repeated pregnancy loss

Journal of Assisted Reproduction and Genetics ◽

10.1007/s10815-010-9435-2 ◽

2010 ◽

Vol 27 (11) ◽

pp. 641-648 ◽

Cited By ~ 12

Author(s):

Seyed Mohammad Seyedhassani ◽

Massoud Houshmand ◽

Seyed Mehdi Kalantar ◽

Glayol Modabber ◽

Abbas Aflatoonian

Keyword(s):

Mitochondrial Dna ◽

Pregnancy Loss ◽

Point Mutations ◽

Dna Deletions ◽

D Loop ◽

Repeated Pregnancy Loss

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Abnormal Thyroid Function and Recurrent Pregnancy Loss

Nepal Journal of Obstetrics and Gynaecology ◽

10.3126/njog.v9i1.11184 ◽

2014 ◽

Vol 9 (1) ◽

pp. 29-32

Author(s):

A Shrestha ◽

CD Chawla

Keyword(s):

Longitudinal Study ◽

Thyroid Function ◽

Autoimmune Thyroiditis ◽

Pregnancy Loss ◽

Recurrent Pregnancy Loss ◽

Thyroid Stimulating Hormone ◽

Thyroid Disorder ◽

Positive Message ◽

Effect Of Treatment ◽

Tsh Levels

Aims: The aim of our study was to observe the benefit of screening for thyroid function amongst women with recurrent pregnancy loss and effect of treatment for thyroid disorder on pregnancy outcome. Methods: This was a longitudinal study conducted from June 2012 to December 2013. One hundred and three patients with recurrent pregnancy loss without features of thyroid disorder were included. They were investigated for thyroid stimulating hormone (TSH), free tri iodothyronin (FT3), free thyroxine (FT4) levels and for auto-antibodies against thyroperoxidase (anti TPO). The patients with abnormal TSH levels were treated with thyroxine depending on the level of TSH. Results: TSH, FT3, FT4 and anti TPO levels were measured. Amongst 103 ladies, thirty-eight (36.89%) had high levels of TSH. Thirty-five (33.98%) of them underwent test for anti TPO, of which two (5.71%) had autoimmune thyroiditis. Nine (8.73%) out of 103 had high FT4 levels. Ladies with diagnosis of hypothyroidism underwent treatment and 17 (44.73%) out of 38 had conceived. Conclusions: Of 103 women with recurrent pregnancy loss, abnormal thyroid function was detected in 47. Seventeen (44.73%) of them with increased TSH level conceived after treatment with thyroxine, which gives a positive message that hypothyroidism is a treatable cause for recurrent pregnancy loss. DOI: http://dx.doi.org/10.3126/njog.v9i1.11184 NJOG 2014 Jan-Jun; 2(1):29-32

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Analysis of Blimp-1 and PD-1/PD-L1 Immune Checkpoint in an Autoimmune Thyroiditis Animal Model

International Journal of Endocrinology ◽

10.1155/2020/6543593 ◽

2020 ◽

Vol 2020 ◽

pp. 1-11

Author(s):

Xue Zhang ◽

Xiaoshu Lv ◽

Mengya Chen ◽

Haixia Liu

Keyword(s):

Signaling Pathway ◽

Autoimmune Thyroiditis ◽

Pregnancy Loss ◽

B Lymphocyte ◽

Fetal Loss ◽

Control Group ◽

Autoimmune Thyroid ◽

Female Mice ◽

Maturation Protein ◽

Cell Death Protein

Objective. B lymphocyte-induced maturation protein 1 (Blimp-1) and programmed cell death protein 1 (PD-1) have opposing roles in the development of T cells; however, the mechanism of autoimmune thyroiditis- (AIT-) associated abortion is unclear. The present study investigated the expression of Blimp-1 and PD-1/PD-ligand 1 (PD-L1) in AIT-associated pregnancy loss and elucidated the related signaling pathway involving in the inflammatory response. Methods. An experimental fetal loss model with autoimmune thyroiditis was established after murine thyroglobulin- (mTg-) immunized CBA/J female mice mating with Balb/c males. ELISA was employed to investigate the TgAb level in the serum of CBA/J female mice. The expression of Blimp-1, PD-1/PD-L1, mammalian target protein rapamycin (mTOR), and Foxp3 proteins in the placenta and spleen was detected through immunofluorescence staining and western blotting. Results. ELISA indicated that the serum TgAb level in the mTg group was higher than that in the control group (P<0.001). Fetal resorption rates increased in the mTg group compared with those in the control group (45.63% vs. 3.1%, P<0.05). Blimp-1 levels in the placenta and spleen were higher in the AIT-related miscarriage group than in the control group. However, the expression of PD-1/PD-L1 and Foxp3 was significantly decreased in the placenta and spleen in the AIT-related miscarriage group. Conclusion. Blimp-1 participates in the pathogenesis of autoimmune thyroid disease-associated pregnancy loss through the inflammatory immune response, which is potentially mediated through the PD-1/PD-L1 signaling pathway.

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Vitiligo in Children and Adolescents: a Lliterature Review / Vitiligo kod dece i omladine - pregled literature

Serbian Journal of Dermatology and Venerology ◽

10.2478/v10249-011-0026-8 ◽

2010 ◽

Vol 2 (3) ◽

pp. 95-104

Author(s):

Sonja Prćić ◽

Verica Đuran ◽

Dragan Katanić

Keyword(s):

Children And Adolescents ◽

Autoimmune Thyroiditis ◽

Thyroid Dysfunction ◽

Social Acceptance ◽

Pediatric Population ◽

Age Groups ◽

Autoimmune Disorders ◽

Self Image ◽

Annual Screening

Abstract Vitiligo is an acquired, often hereditary skin depigmentation disorder, characterized by discrete, well-circumscribed, chalk-white macules or patches. It affects all age groups, but in more than half of the patients it occurs before the age of twenty, when self-image is being formed and social acceptance is of great importance. Although similar to the disease in adults, vitiligo in children and adolescents does have differences in epidemiology, association with other endocrine and/or autoimmune disorders, and treatment. This is a review of vitiligo in the pediatric population, emphasizing key differences with vitiligo in adults. According to the literature reports, we suggest that children and adolescents with vitiligo, especially non-segmental type, should perform annual screening for thyroid dysfunction, particularly for parameters of autoimmune thyroiditis.

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