Glycated haemoglobin and obstetric outcomes among patients with gestational diabetes mellitus: a single center study

Objectives: Insulin receptor substrate 1 (IRS1) is a crucial factor in the insulin signaling pathway. IRS1 gene polymorphism rs1801278 in mothers has been reported to be associated with gestational diabetes mellitus (GDM). However, it is not clear whether IRS1 gene polymorphism rs1801278 in fetuses is associated with their mothers’ GDM morbidity. The purpose of this study is to analyze the association between maternal, fetal, or maternal/fetal IRS1 gene polymorphism rs1801278 and GDM risk. Design: The study was a single-center, prospective cohort study. In total, 213 pairs of GDM mothers/fetuses and 191 pairs of control mothers/fetuses were included in this study. They were recruited after they underwent oral glucose tolerance test during 24–28 weeks of gestation and followed up until delivery. All participants received the conventional interventions (diet and exercise), and no special therapy except routine treatment. Methods: A total of 213 pairs of GDM mothers/fetuses and 191 pairs of normal blood glucose pregnant mothers/fetuses were genotyped using PCR and DNA sequencing from January 2015 to September 2016. Maternal/fetal IRS1 gene polymorphism rs1801278 was analyzed and compared between 2 groups. Results: There were no significant differences in the frequency of individual mothers’ or fetuses’ IRS1 rs1801278 polymorphisms between 2 groups; if both the mothers and fetuses carried A allele, significantly lower GDM morbidity was observed in the mothers. Limitations: The sample size was relatively small as a single-center study. Conclusions: Our study suggested that maternal/fetal rs1801278 polymorphism of IRS1 is a modulating factor in GDM; both mothers/fetuses carrying the A allele of rs1801278 may protect the mothers against the development of GDM.

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Evaluation of perceived fears of COVID-19 virus infection and its relationship to health-related quality of life among patients with diabetes mellitus in Egypt during pandemic: a developing country single-center study

Diabetology International ◽

10.1007/s13340-021-00511-8 ◽

2021 ◽

Author(s):

Mohamed Abdelghani ◽

Mohamed G. Hamed ◽

Amira Said ◽

Eman Fouad

Keyword(s):

Quality Of Life ◽

Diabetes Mellitus ◽

Health Related Quality ◽

Single Center ◽

Single Center Study ◽

Patients With Diabetes ◽

Related Quality ◽

Health Related ◽

Center Study

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A novel dual imprinted conducting nanocubes based flexible sensor for simultaneous detection of hemoglobin and glycated haemoglobin in gestational diabetes mellitus patients

Sensors and Actuators B Chemical ◽

10.1016/j.snb.2019.01.093 ◽

2019 ◽

Vol 285 ◽

pp. 470-478 ◽

Cited By ~ 5

Author(s):

Indu Pandey ◽

Jai Deo Tiwari

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Simultaneous Detection ◽

Glycated Haemoglobin ◽

Flexible Sensor

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Obstructive sleep apnea and excessive daytime sleepiness among patients with type 2 diabetes mellitus: a single-center study from Iran

International Journal of Diabetes in Developing Countries ◽

10.1007/s13410-014-0281-0 ◽

2015 ◽

Vol 35 (S2) ◽

pp. 189-193 ◽

Cited By ~ 1

Author(s):

Khosro Sadeghniiat-Haghighi ◽

Mohammad Reza Mohajeri-Tehrani ◽

Ahmad Khajeh-Mehrizi ◽

Farhad Fathi ◽

Farzad Saremi-Rasouli ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Obstructive Sleep Apnea ◽

Type 2 Diabetes Mellitus ◽

Sleep Apnea ◽

Single Center ◽

Obstructive Sleep ◽

Single Center Study ◽

Center Study

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Gestational diabetes mellitus and obstetric outcomes in a Ghanaian community

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20185424 ◽

2018 ◽

Vol 8 (1) ◽

pp. 204

Author(s):

Ahmed Tijani Bawah ◽

Robert Amadu Ngala ◽

Mohammed Mustapha Seini ◽

Francis Abeku Ussher ◽

Huseini Alidu ◽

...

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnancy Outcome ◽

Obstetric Outcomes ◽

Retrospective Case ◽

Family History Of Diabetes ◽

Maternal Characteristics ◽

History Of ◽

Control Study

Background: This study was aimed at evaluating effect of Gestational diabetes mellitus (GDM) and maternal characteristics on pregnancy outcomes. GDM has several risk factors including; advanced maternal age, ethnic background, obesity and family history of diabetes mellitus. These pregnancy complications are associated with fetal morbidity and mortality and may lead to macrosomia and shoulder dystocia. Others are stillbirth, miscarriages, preterm and small for gestational age babies.Methods: This was a retrospective case-control study which compared maternal characteristics and pregnancy outcome among pregnant women with and without GDM. Diagnosis of GDM was done in accordance with the American Diabetes Association (ADA) criteria. Weight and height were determined and Body mass index (BMI) calculated. Pregnancy outcome was determined at the end of pregnancy and information on maternal characteristics obtained using questionnaire and patient folders.Results: Those who developed GDM were significantly older (OR=1.772; 95% CI=1.432-2.192; P<0.0001) and had higher BMI (OR=1.637; 95% CI=1.004-1.289; P=0.044) than those who did not. A significant number of those who developed GDM also had stillbirths (OR= 5.188; 95% CI=1.093-24.613; p=0.038) and cesarean deliveries (OR=14.362; 95% CI=3.661-56.335; p= 0.001).Conclusions: Women who develop GDM are more likely to deliver stillborn or macrosmic babies and may require surgical intervention in order to have normal deliveries.

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