Study on Magnetic Behaviour of Iron Oxide Nanoparticle, A Nano Anticancer Drug Delivery Vehicle Synthesized by Modified Chemical Co-Precipitation

2012 ◽  
Vol 3 (8) ◽  
pp. 218-219
Author(s):  
Dr.Naheef.K Dr.Naheef.K ◽  
◽  
RM Chavan RM Chavan
2019 ◽  
Vol 237 ◽  
pp. 121860 ◽  
Author(s):  
Poushali Das ◽  
Sayan Ganguly ◽  
Tarun Agarwal ◽  
Pritiprasanna Maity ◽  
Sabyasachi Ghosh ◽  
...  

Pharmaceutics ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 120 ◽  
Author(s):  
Thai Hoang Thi ◽  
Diem-Huong Nguyen Tran ◽  
Long Bach ◽  
Hieu Vu-Quang ◽  
Duy Nguyen ◽  
...  

Polymer coating has drawn increasing attention as a leading strategy to overcome the drawbacks of superparamagnetic iron oxide nanoparticles (SPIONs) in targeted delivery of anticancer drugs. In this study, SPIONs were modified with heparin-Poloxamer (HP) shell to form a SPION@HP core-shell system for anticancer drug delivery. The obtained formulation was characterized by techniques including transmission electron microscopy (TEM), Fourier transform infrared spectra (FT-IR), vibration sample magnetometer (VSM), proton nuclear magnetic resonance (1H-NMR), and powder X-ray diffraction (XRD). Results showed the successful attachment of HP shell on the surface of SPION core and the inability to cause considerable effects to the crystal structure and unique magnetic nature of SPION. The core-shell system maintains the morphological features of SPIONs and the desired size range. Notably, Doxorubicin (DOX), an anticancer drug, was effectively entrapped into the polymeric shell of SPION@HP, showing a loading efficiency of 66.9 ± 2.7% and controlled release up to 120 h without any initial burst effect. Additionally, MTT assay revealed that DOX-loaded SPION@HP exerted great anticancer effect against HeLa cells and could be safely used. These results pave the way for the application of SPION@HP as an effective targeted delivery system for cancer treatment.


2019 ◽  
Vol 7 (1) ◽  
pp. 143-149 ◽  
Author(s):  
Gang He ◽  
Yan Ma ◽  
Hu Zhou ◽  
Siyuan Sun ◽  
Xianwen Wang ◽  
...  

Monodispersed mesoporous NiS2 nanospheres (mNiS2 NSs) have been successfully developed here through a facile solvothermal method to act as a hydrophobic drug delivery vehicle for synergistic photothermal–chemo treatment of cancer.


2014 ◽  
Vol 196 ◽  
pp. 234-242 ◽  
Author(s):  
Si Eun Baek ◽  
Kwang Hyun Lee ◽  
Yong Serk Park ◽  
Deok-Kun Oh ◽  
Sangtaek Oh ◽  
...  

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