scholarly journals Effect of Laser Radiation on Biomolecules

2020 ◽  
Vol 7 (2) ◽  
pp. 123-128
Author(s):  
E. Prieto ◽  
L. X. Hallado ◽  
A. Guerrero ◽  
I. Álvarez ◽  
C. Cisneros
Keyword(s):  
Laser Radiation ◽  
Radiation Field ◽  
Time Of Flight ◽  
Secondary Electrons ◽  
Rna Molecules ◽  
Nitrogen Bases ◽  
Dna And Rna ◽  
Biological Interest ◽  
Laser Photoionization ◽  
Purines And Pyrimidines

Time of flight laser photoionization has been used to study the response of some molecules of biological interest under laser radiation. One of the questions of great interest today is the effect of radiation on DNA and RNA molecules. Damage to these molecules can be caused directly by radiation or indirectly by secondary electrons created by radiation. As response of the radiation field fragmentation process can occur producing different ions with kinetic energies of a few electron volts. In this paper we present the results of the interaction of 355nm laser with the nitrogen bases adenine(A) and uracil(U) using time-of-flight spectrometry and the comparison of experimental results on the effects of laser radiation in (A) and (U) belonging to two different ring groups, purines and pyrimidines respectively,which are linked to form the AU pair of the RNA.

Conformation change of enzyme molecules in laser radiation field

2007 ◽  
Author(s):  
N. S. Leshenyuk ◽  
M. V. Prigun ◽  
E. E. Apanasevitsh ◽  
G. S. Kruglik
Keyword(s):  
Laser Radiation ◽  
Radiation Field ◽  
Conformation Change ◽  
Laser Radiation Field ◽  
Enzyme Molecules

scholarly journals Modelling the line shape of very low energy peaks of positron beam induced secondary electrons measured using a time of flight spectrometer

2017 ◽  
Vol 791 ◽  
pp. 012030 ◽  
Author(s):  
A J Fairchild ◽  
V A Chirayath ◽  
R W Gladen ◽  
M D Chrysler ◽  
A R Koymen ◽  
...  
Keyword(s):  
Line Shape ◽  
Time Of Flight ◽  
Positron Beam ◽  
Low Energy ◽  
Secondary Electrons

scholarly journals Pyrido[2,3-d]pyrimidin-7(8H)-ones: Synthesis and Biomedical Applications

Molecules ◽  
2019 ◽  
Vol 24 (22) ◽  
pp. 4161 ◽  
Author(s):  
Guillem Jubete ◽  
Raimon Puig de la Bellacasa ◽  
Roger Estrada-Tejedor ◽  
Jordi Teixidó ◽  
José I. Borrell
Keyword(s):  
Biomedical Applications ◽  
Pyridine Ring ◽  
General Structure ◽  
Pyrimidine Ring ◽  
The Body ◽  
Synthetic Methods ◽  
Present Review ◽  
Nitrogen Bases ◽  
Dna And Rna

Pyrido[2,3-d]pyrimidines (1) are a type of privileged heterocyclic scaffolds capable of providing ligands for several receptors in the body. Among such structures, our group and others have been particularly interested in pyrido[2,3-d]pyrimidine-7(8H)-ones (2) due to the similitude with nitrogen bases present in DNA and RNA. Currently there are more than 20,000 structures 2 described which correspond to around 2900 references (half of them being patents). Furthermore, the number of references containing compounds of general structure 2 have increased almost exponentially in the last 10 years. The present review covers the synthetic methods used for the synthesis of pyrido[2,3-d]pyrimidine-7(8H)-ones (2), both starting from a preformed pyrimidine ring or a pyridine ring, and the biomedical applications of such compounds.

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