The National Institute of Child Health and Human Development and Phenylketonuria

PEDIATRICS ◽  
2003 ◽  
Vol 112 (Supplement_4) ◽  
pp. 1514-1515 ◽  
Author(s):  
Duane Alexander
Keyword(s):  
Mental Retardation ◽  
Child Health ◽  
Protective Effect ◽  
Human Development ◽  
Fetal Development ◽  
Newborn Infants ◽  
Adverse Impact ◽  
Term Efficacy

The National Institute of Child Health and Human Development (NICHD) was established shortly after the Guthrie test for screening newborn infants for phenylketonuria (PKU) was introduced. The NICHD supported the study demonstrating the long-term efficacy of screening and a low-phenylalanine diet in preventing mental retardation. With the identification of the adverse impact on fetal development of high intrauterine phenylalanine exposure from a mother with PKU, the NICHD organized and supported the study reported here, demonstrating the protective effect of phenylalanine restriction of the mother’s diet during pregnancy. The study provides clear guidance for the management of pregnancy in women with PKU.

Inhibition of Ras/ERK1/2 pathway contributes to the protective effect of Ginsenoside Re against intimal hyperplasia

2021 ◽  
Author(s):  
Chenying Gao ◽  
Kaina Zhang ◽  
Fanfan Liang ◽  
Wenzhuo Ma ◽  
Xixi Jiang ◽  
...  
Keyword(s):  
Protective Effect ◽  
Endovascular Treatment ◽  
Carotid Stenosis ◽  
Vascular Injury ◽  
Intimal Hyperplasia ◽  
Neointimal Hyperplasia ◽  
Ginsenoside Re ◽  
Term Efficacy

Neointimal hyperplasia is the major cause of carotid stenosis after vascular injury, which restricts the long-term efficacy of endovascular treatment and endarterectomy in preventing stenosis. Ginsenoside Re (Re) is a...

scholarly journals Correlation of Environment, Nutrition, Genetics, Epigenetics, Microbiota with Neonatal Fetus Development

2021 ◽  
Author(s):  
Iván Enrique Naranjo Logroño ◽  
Anthony Alfonso Naranjo Coronel ◽  
Angie Daniela Beltrán Vera ◽  
Ashley Carolina Cuzco Macías
Keyword(s):  
Human Development ◽  
Fetal Development ◽  
Phenotypic Expression ◽  
External Factors ◽  
Neonatal Development ◽  
Palabras Clave ◽  
The Subject ◽  
The Moment ◽  
The Relationship

Introduction: From the moment of conception the human being is predisposed to undergo changes in fetal and neonatal development due to various external factors that occur throughout life and can in the long term influence the phenotypic expression of the new being. Objective: The objective of this work is to determine the relationship between the environment, nutrition, genetics, epigenetics and microbiota with neonatal fetus development and how they influence the phenotypic expression of the new being. Methods: A non-systematic search was performed in electronic databases such as COCHRANE, PUBMED, MEDLINE, etc. The bibliographic research was carried out in the period between October 2019 and January 2020. The studies carried out from 2007 to 2019, in the languages of Spanish and English, were included. Results: We found 51 bibliographic sources related to the subject, of which by means of a last simplification, 30 scientific articles were used that provided important information on the subject, and 21 articles were excluded. Conclusion: Research on methods to detect these interactions and to understand the mechanisms of these interactions is just beginning. However, there is evidence that they play an important role in human development. Keywords: neonatal development, epigenetics, microbiota, fetal development, nutrition. RESUMEN Introducción: Desde el momento de la concepción el ser humano está predispuesto a sufrir cambios en el desarrollo fetal y neonatal debido a diversos factores externos que se presentan a lo largo de la vida y pueden a largo plazo influir en la expresión fenotípica del nuevo ser. Objetivo: El objetivo del presente trabajo es determinar la relación que existe entre el medio ambiente, nutrición, genética, epigenética y microbiota con el desarrollo feto neonatal y como los mismos influyen en la expresión fenotípica del nuevo ser. Métodos: Se realizó una búsqueda no sistemática en bases de datos electrónicas como COCHRANE, PUBMED, MEDLINE, etc. La investigación bibliográfica se realizó en el periodo comprendido entre octubre 2019 y enero 2020. Se incluyeron estudios realizados desde el año 2007 hasta el año 2019, en los idiomas de español e inglés. Resultados: Se encontraron 51 fuentes bibliográficas referentes al tema, de los cuales mediante una última simplificación se utilizaron 30 artículos científicos que aportaron información importante del tema y se excluyeron 21 artículos. Conclusiones: La investigación sobre métodos para detectar estas interacciones y para comprender los mecanismos de estas interacciones apenas está comenzando. Sin embargo, hay evidencia de que estas juegan un papel importante en el desarrollo humano. Palabras clave: desarrollo neonatal, epigenética, microbiota, desarrollo fetal, nutrición.

Phototherapy for Neonatal Hyperbilirubinemia

PEDIATRICS ◽  
1986 ◽  
Vol 78 (1) ◽  
pp. 179-180
Author(s):  
RONALD L. POLAND
Keyword(s):  
Randomized Controlled Trial ◽  
Child Health ◽  
Human Development ◽  
Exchange Transfusion ◽  
Controlled Trial ◽  
Newborn Infants ◽  
Neonatal Hyperbilirubinemia ◽  
Study Group ◽  
Cooperative Study ◽  
Randomized Controlled

To the Editor.— I read with fascination the reports of the 1974-1976 National Institute of Child Health and Human Development Randomized, Controlled Trial of Phototherapy for Neonatal Hyperbilirubinemia.1 The results of this well-designed cooperative study are extremely important for the care of newborn infants. Focusing on the smallest infants reported, we find that the use of prophylactic phototherapy was associated with a significant reduction in the need for exchange transfusion.2 The study group, however, used a liberal set of criteria for exchange transfusion compared to others published recently.3-5

CO2 Laser Offers Long-Term Efficacy

2008 ◽  
Vol 39 (9) ◽  
pp. 31
Author(s):  
ROBIN TURNER
Keyword(s):  
Co2 Laser ◽  
Term Efficacy
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