Maternal Serum Vitamin D Levels During Pregnancy and Offspring Neurocognitive Development

Abstract Background: This study was thus undertaken to study the estimation of vitamin D levels in pregnant women and their newborns in DRC and to study its association with various neonatal outcomes. Methods: Observational study done on 569 pregnant women and their newborn babies. Sample obtained from maternal serum and cord blood from the placental end during peripartum period. The data was analysed to estimate the prevalence of vitamin D levels in mothers and newborns and to identify association, if any, between maternal vitamin D levels and neonatal outcomes.Results: 464 mothers had sufficient vitamin D (VDS) levels (>30 ng/dL) and 105 had vitamin D deficiency (VDD) with mean maternal serum vitamin D level of 35.63ng/ml (SD 6.18, range 9.2-39.8). All the newborns (n=569) were vitamin D deficient (<30ng/ml). The percentage of LBW babies born to VDD mothers was 18.09%, which was very similar to the percentage of LBW babies born to VDS mothers (18.31%) (p=0.76456749). The incidence of caesarean section was 58.09% in the vitamin D deficient (VDD) group as compared to 19.61% in the sufficient (VDS) group (p<0.0005). The incidence of preterm births was 10.77% in the sufficient group (VDS) as compared to 17.14% in the vitamin D deficient (VDD) group (p=0.038). Conclusion: Our findings will help health professionals, policy makers, and the general public in Africa aware of the high prevalence of vitamin D deficiency and the associated health risks.

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A Study of Relationship Between Maternal Vitamin D Status and Mode of Delivery in a Tertiary Care Military Hospital

10.21203/rs.3.rs-35417/v1 ◽

2020 ◽

Author(s):

Gurpreet Kaur Dhillon ◽

Suneeta Singh ◽

Harpreet Singh Dhillon ◽

Shibu Sasidharan

Keyword(s):

Vitamin D ◽

Cesarean Section ◽

Vaginal Delivery ◽

Tertiary Care ◽

Mode Of Delivery ◽

Serum Vitamin ◽

Maternal Serum ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

The Relationship

Abstract Background: Vitamin D deficiency has been shown to be related to multiple adverse pregnancy related outcomes. An observational study was undertaken to study the relationship between maternal serum vitamin D levels during peripartum period and outcome in the form of mode of delivery.Methods: This study was done in a tertiary care centre on 569 patients to study the relationship between maternal serum vitamin D levels and mode of delivery categorized into vaginal delivery (VD), (including assisted delivery) and Lower Segment Cesarean Section (LSCS). The primary objective of this project was to assess the vitamin D levels in maternal serum and to study its relationship, if any, with mode of delivery. Results: A total of 569 samples of maternal and neonatal serum were analyzed for serum 25(OH)D levels. 464 (81.54%) mothers had Vitamin D sufficient (VDS) levels ≥30ng/ml and 105 (18.45%) had vitamin D deficient (VDD) levels <30ng/ml. Out of total 569 newborns; LSCS and spontaneous Vaginal Delivery were 152 (26.71%) and 417 (73.28%) respectively. The incidence of LSCS was 19.61% in the vitamin D sufficient group as compared to 58.09% in the vitamin D deficient group (p<0.0005). The mean cord blood 25(OH) D levels of the neonates born by vaginal delivery was 14.05ng/ml (SD 3.86, range 8.2-27) whereas those born by LSCS was 12.11 ng/ml (SD 3.18, range 7.9-22), which was significantly lower (p<0.00000042).Conclusion: The rates of Cesarean section deliveries was 2.96 times higher in mothers who had deficient Vitamin D levels. Also the levels of mean cord blood vitamin D was higher in vaginally delivered newborns.

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Association of serum vitamin D levels with gestational diabetes mellitus

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20212147 ◽

2021 ◽

Vol 10 (6) ◽

pp. 2198

Author(s):

Sharmeen Mahmood ◽

Hasna Hena Pervin ◽

Shereen Yousuf

Keyword(s):

Vitamin D ◽

Pregnant Women ◽

Serum Vitamin ◽

Maternal Serum ◽

Control Group ◽

Case Group ◽

Vitamin D Status ◽

Third Trimester ◽

Serum Vitamin D ◽

Vitamin D Levels

Background: This study was done to evaluate the association of serum vitamin D level with GDM (n=30) and without GDM (n=30). The age and body mass index of the participants along with their gestational age, gravidity and parity were harmonized. The serum vitamin D levels and blood glucose were investigated. The results revealed that, normal pregnant women had significantly higher vitamin D level than their GDM counterparts.Methods: This case-control study was conducted on healthy pregnant women attending routine antenatal care at Bangabandhu Sheikh Mujib medical university from January 2019 to December 2019 recruited at third trimester of gestation. We measured maternal serum vitamin D status (25[OH]D) in third trimester of pregnancy. GDM was diagnosed according to the American diabetes association. guidelines. Vitamin D status was defined as, vitamin D sufficiency (≥30 or ≥75 nmol/L), insufficiency (20-30 and 50-75 nmol/L), were used to categories participants according to their 25[OH]D concentrations. We calculated adjusted odds ratios and 95% confidence intervals (CIs) using logistic regression.Results: The mean serum vitamin D level was lower in case group case 23.4 (17.4±35.1) compared to that in control group 29.7 (15.4±39.8) and the difference between the 2 groups was statistically significant (p≤0.001). Sufficient level of vitamin D was more in control group (66.7%) than that of case group (26.1%). Insufficient level of vitamin D was higher in case (73.3%) group than that of control (33.3%) group. These findings were significant (p=0.021). Respondents with insufficient level of vitamin D have 3.1 times more chance to develop GDM.Conclusions: Serum vitamin D level is reduced in pregnant women having GDM.

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Maternal serum vitamin D levels and pregnancy outcomes: from Lagos, Nigeria

Journal of Obstetrics and Gynaecology ◽

10.1080/01443615.2016.1196483 ◽

2016 ◽

Vol 37 (1) ◽

pp. 25-28 ◽

Cited By ~ 7

Author(s):

Abidoye Gbadegesin ◽

Adekunle Sobande ◽

Oluwole Adedeji ◽

Elizabeth Disu ◽

Oluwatosin Korede ◽

...

Keyword(s):

Vitamin D ◽

Pregnancy Outcomes ◽

Serum Vitamin ◽

Maternal Serum ◽

Serum Vitamin D ◽

Vitamin D Levels

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A study of relationship between maternal serum vitamin D levels during peripartum period and neonatal birth weight

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20202621 ◽

2020 ◽

Vol 7 (7) ◽

pp. 1584

Author(s):

Gurpreet K. Dhillon ◽

Sunil K. Rai ◽

Harpreet S. Dhillon ◽

Shibu Sasidharan

Keyword(s):

Vitamin D ◽

Birth Weight ◽

Serum Vitamin ◽

Maternal Serum ◽

Serum Samples ◽

Serum Vitamin D ◽

Neonatal Birth Weight ◽

Vitamin D Levels ◽

Peripartum Period ◽

The Relationship

Background: An observational study was undertaken to study the relationship between maternal serum vitamin D levels during peripartum period and neonatal birth weight.Methods: This study was done on 569 patients to study the relationship between maternal serum vitamin D levels during peripartum period and neonatal birth weight. The data included was maternal serum samples (taken during peri-partum period) and neonatal birth weight. The primary objective of this project was to assess the vitamin D levels in maternal serum and to study its relationship, if any, with birth weight in the neonates.Results: A total of 569 samples of maternal serum were analyzed for serum 25(OH)D levels out of which 457(80%) mothers were found to have sufficient, 101(18%) insufficient and 11(2%) deficient Vitamin D levels as per US Endocrinological society guidelines. Out of total 569 newborns, 104 (18.27%) were low birth weight (LBW) and 465 (81.27%) were normal birth weight (NBW). Out of total LBW (104), 19(18.27%) were born to vitamin D deficient (VDD) mothers and 85 (81.72%) were born to vitamin D sufficient (VDS) mothers. Out of total NBW(465), 86(18.45%) were born to VDD mothers and 379 (81.17%) were born to VDS mothers. These results were not statistically significant (p=0.76456749).Conclusions: Maternal 25(OH)-vitamin D status during late pregnancy did not have any statistically significant effect on the neonatal birth weight.

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The Assessment of Vitamin D Levels in Pregnant Women is not Associated to Fetal Growth Restriction: A Cross Sectional Study

Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics ◽

10.1055/s-0041-1735158 ◽

2021 ◽

Vol 43 (10) ◽

pp. 743-748

Author(s):

Vivian Macedo Gomes Marçal ◽

Francisco Lázaro Pereira Sousa ◽

Silvia Daher ◽

Raquel Margiotte Grohmann ◽

Alberto Borges Peixoto ◽

...

Keyword(s):

Vitamin D ◽

Pregnant Women ◽

Gestational Age ◽

Serum Vitamin ◽

Cross Sectional Study ◽

Maternal Serum ◽

Sectional Study ◽

Cross Sectional ◽

Serum Vitamin D ◽

Vitamin D Levels

Abstract Objective To assess maternal serum levels of vitamin D in fetuses appropriate for gestational age (AGA), small for gestational age (SGA), and with fetal growth restriction (FGR) according to estimated fetal weight (EFW). Methods This cross-sectional study included 87 pregnant women between 26 and 36 weeks of gestation: 38 in the AGA group, 24 in the SGA group, and 25 in the FGR group. Maternal serum vitamin D levels were assessed using the chemiluminescence method. The Fisher exact test was used to compare the results between the groups. Results The mean ± standard deviation (SD) of maternal age (years) and body mass index (kg/m2) in the AGA, SGA, and FGR groups were 25.26 ± 8.40 / 26.57 ± 4.37; 25.04 ± 8.44 / 26.09 ± 3.94; and 25.48 ± 7.52 / 26.24 ± 4.66, respectively (p > 0.05). The maternal serum vitamin D levels (mean ± SD) of the AGA, SGA, and FGR groups were 22.47 ± 8.35 ng/mL, 24.80 ± 10.76 ng/mL, and 23.61 ± 9.98 ng/mL, respectively, but without significant differences between the groups (p = 0.672). Conclusion Maternal serum vitamin D levels did not present significant differences among pregnant women with AGA, SGA, or FGR fetuses between 26 and 36 weeks of gestation according to EFW.

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