Foundations of Neuropsychiatry

PEDIATRICS ◽  
1949 ◽  
Vol 3 (2) ◽  
pp. 253-253
Keyword(s):  
Central Nervous System ◽  
Blood Flow ◽  
Nervous System ◽  
Cerebral Cortex ◽  
Cerebral Blood Flow ◽  
Harvard Medical School ◽  
Massachusetts General Hospital ◽  
Three Dimensional ◽  
The Central Nervous System ◽  
Disease Entities

Gives the facts and correlation needed to understand the simple workings of the central nervous system. Serves as a preface to start the student with three dimensional orientation towards neurology and psychiatry, leading up to a description of the principal disease entities. The chapters on cerebral blood flow, the types of neurons in the autonomic system and the motor areas of the cerebral cortex have been largely rewritten. The author is Bullard Professor of Neuropathology, Harvard Medical School and Psychiatrist in Chief, Massachusetts General Hospital.

Glucuronyl 3-sulfate occurs exclusively on distal unmyelinated terminals of selected sensory neurons in the peripheral nervous system

1995 ◽  
Vol 53 ◽  
pp. 958-959
Author(s):  
S.S. Spicer ◽  
B.A. Schulte
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cerebral Cortex ◽  
Peripheral Nervous System ◽  
Sensory Neurons ◽  
Sensory Nerves ◽  
Tissue Antigens ◽  
The Central Nervous System ◽  
The Brain ◽  
Leu 7

Generation of monoclonal antibodies (MAbs) against tissue antigens has yielded several (VC1.1, HNK- 1, L2, 4F4 and anti-leu 7) which recognize the unique sugar epitope, glucuronyl 3-sulfate (Glc A3- SO4). In the central nervous system, these MAbs have demonstrated Glc A3-SO4 at the surface of neurons in the cerebral cortex, the cerebellum, the retina and other widespread regions of the brain.Here we describe the distribution of Glc A3-SO4 in the peripheral nervous system as determined by immunostaining with a MAb (VC 1.1) developed against antigen in the cat visual cortex. Outside the central nervous system, immunoreactivity was observed only in peripheral terminals of selected sensory nerves conducting transduction signals for touch, hearing, balance and taste. On the glassy membrane of the sinus hair in murine nasal skin, just deep to the ringwurt, VC 1.1 delineated an intensely stained, plaque-like area (Fig. 1). This previously unrecognized structure of the nasal vibrissae presumably serves as a tactile end organ and to our knowledge is not demonstrable by means other than its selective immunopositivity with VC1.1 and its appearance as a densely fibrillar area in H&E stained sections.

Developmental Overview of Central Neuroanatomy

2017 ◽  
Author(s):  
Peggy Mason
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Cerebral Cortex ◽  
Neural Tube ◽  
The Central Nervous System ◽  
Dorsal Telencephalon ◽  
Adult Spinal Cord ◽  
The Brain

The central nervous system develops from a proliferating tube of cells and retains a tubular organization in the adult spinal cord and brain, including the forebrain. Failure of the neural tube to close at the front is lethal, whereas failure to close the tube at the back end produces spina bifida, a serious neural tube defect. Swellings in the neural tube develop into the hindbrain, midbrain, diencephalon, and telencephalon. The diencephalon sends an outpouching out of the cranium to form the retina, providing an accessible window onto the brain. The dorsal telencephalon forms the cerebral cortex, which in humans is enormously expanded by growth in every direction. Running through the embryonic neural tube is an internal lumen that becomes the cerebrospinal fluid–containing ventricular system. The effects of damage to the spinal cord and forebrain are compared with respect to impact on self and potential for improvement.

Monitoring of Transient Central Nervous System Postirradiation Effects by 133Xe Inhalation Regional Cerebral Blood Flow Measurements

Neurosurgery ◽  
1987 ◽  
Vol 21 (6) ◽  
pp. 843-848 ◽  
Author(s):  
Phillip D. Hylton ◽  
Howard O. Reichman ◽  
Roberta Palutsis
Keyword(s):  
Central Nervous System ◽  
Blood Flow ◽  
Nervous System ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Inhalation Technique ◽  
Regional Cerebral Blood ◽  
Whole Brain Irradiation ◽  
Metabolic Derangement ◽  
Flow Measurements

Abstract The early transient postirradiation effects in the central nervous system are well known; however, no specific means of objective follow-up have been devised. The xenon (133Xe) inhalation technique for measurement of regional cerebral blood flow (rCBF) is easily reproducible. Serial rCBF measurements corresponding to the clinical presentation and course of the early postirradiation syndrome have not been previously reported. It is our belief that the global decline in rCBF identified in these patients represents a generalized metabolic derangement induced by whole brain irradiation rather than primary vascular changes. A distinction between tumor recurrence and the early transient postirradiation effects can be made utilizing this technique. It also provides a reproducible monitor of the clinical and metabolic impact of radiotherapy for brain tumors. A series of seven such patients is presented with appropriate case histories and graphic representations of the serial rCBF measurements.

scholarly journals Central nervous system vasculopathy caused by Fabry disease: a case report and literature review

2019 ◽  
Author(s):  
De-Zheng Kong ◽  
Ya-Hui Lian ◽  
Lin-Jing Wang ◽  
Chun-Mei Wang ◽  
Yang-Yang Meng ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Fabry Disease ◽  
Initial Treatment ◽  
Spin Echo ◽  
Three Dimensional ◽  
Young Patients ◽  
Vascular Wall ◽  
Black Blood ◽  
The Central Nervous System

Abstract Background Fabry disease is rare, and often the diagnosis is delayed. Here, we describe a case of Fabry disease resulting in vasculopathy of the central nervous system. Magnetic resonance (MR) black-blood sequence (three-dimensional T1 volumetric isotropic turbo spin echo acquisition), with a unique advantage of imaging the vascular wall, facilitated a clear identification of the vasculopathy. Case presentation A 27-year-old man visited our hospital for the treatment of " double vision 6d." After a series of examinations, the patient was diagnosed with Fabry disease, which caused vasculopathy of the central nervous system. Subsequently, the patient was treated with corticosteroids and his symptoms were attenuated. Two months after the initial treatment, the initial lesion formed in the vascular vessel disappeared, however, a new lesion appeared. Similarly, four months after the initial treatment, although the previous lesion disappeared, a new lesion appeared. Conclusions This case highlights that clinicians should use MR black-blood sequence scan in a timely manner in case of young patients with repeated strokes and migratory lesions. In case of detection of a vascular lesion in combination with other systemic lesions, the possibility of Fabry disease should be considered.

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