THIRTEEN BOYS WITH PROGRESSIVE SEPTIC GRANULOMATOSIS

PEDIATRICS ◽  
1965 ◽  
Vol 35 (3) ◽  
pp. 405-412
Author(s):  
Merl J. Carson ◽  
David L. Chadwick ◽  
Charles A. Brubaker ◽  
Robert S. Cleland ◽  
Benjamin H. Landing
Keyword(s):  
Pulmonary Disease ◽  
Fatal Outcome ◽  
Chronic Pulmonary Disease ◽  
Antibody Synthesis ◽  
Frequent Finding ◽  
Suppurative Lymphadenitis

1. Thirteen boys are described who present a syndrome of chronic suppurative lymphadenitis, chronic dermatitis, chronic pulmonary disease, and hepatosplenomegaly, with an eventually fatal outcome. 2. The cases described appear to have the same basic disorder as those previously reported by Landing and Shirkey and by Bridges, Berendes, and Good. 3. Despite the frequent finding of hypergammaglobulinemia, no defect of antibody synthesis has been demonstrated. 4. The existence of an as yet unidentified physiological defect common to these patients is suggested.

Characteristics and outcomes of acute COVID-19 infection in paediatric and young adult patients with underlying cardiac disease

2021 ◽  
pp. 1-7
Author(s):  
Joshua M. Fisher ◽  
Sarah Badran ◽  
John T. Li ◽  
Jodie K. Votava-Smith ◽  
Patrick M. Sullivan
Keyword(s):  
Risk Factors ◽  
Young Adult ◽  
Pulmonary Disease ◽  
Cardiac Disease ◽  
Single Ventricle ◽  
Cardiac Risk ◽  
Adult Patients ◽  
Chronic Pulmonary Disease ◽  
Cardiac Risk Factors ◽  
Increased Risk

Abstract Objective To describe outcomes of acute coronavirus disease 2019 in paediatric and young adult patients with underlying cardiac disease and evaluate the association between cardiac risk factors and hospitalisation. Study design We conducted a retrospective single-institution review of patients with known cardiac disease and positive severe acute respiratory syndrome coronavirus 2 RT-PCR from 1 March, 2020 to 30 November, 2020. Extracardiac comorbidities and cardiac risk factors were compared between those admitted for coronavirus disease 2019 illness and the rest of the cohort using univariate analysis. Results Forty-two patients with a mean age of 7.7 ± 6.7 years were identified. Six were 18 years of age or more with the oldest being 22 years of age. Seventy-six percent were Hispanic. The most common cardiac diagnoses were repaired cyanotic (n = 7, 16.6%) and palliated single ventricle (n = 7, 16.6%) congenital heart disease. Fourteen patients (33.3%) had underlying syndromes or chromosomal anomalies, nine (21%) had chronic pulmonary disease and eight (19%) were immunosuppressed. Nineteen patients (47.6%) reported no symptoms. Sixteen (38.1%) reported only mild symptoms. Six patients (14.3%) were admitted to the hospital for acute coronavirus disease 2019 illness. Noncardiac comorbidities were associated with an increased risk of hospitalisation (p = 0.02), particularly chronic pulmonary disease (p = 0.01) and baseline supplemental oxygen requirement (p = 0.007). None of the single ventricle patients who tested positive required admission. Conclusions Hospitalisations for coronavirus disease 2019 were rare among children and young adults with underlying cardiac disease. Extracardiac comorbidities like pulmonary disease were associated with increased risk of hospitalisation while cardiac risk factors were not.

scholarly journals Statin for Tuberculosis and Pneumonia in Patients with Asthma–Chronic Pulmonary Disease Overlap Syndrome: A Time-Dependent Population-Based Cohort Study

2018 ◽  
Vol 7 (11) ◽  
pp. 381 ◽  
Author(s):  
Jun-Jun Yeh ◽  
Cheng-Li Lin ◽  
Chung-Y. Hsu ◽  
Zonyin Shae ◽  
Chia-Hung Kao
Keyword(s):  
Pulmonary Disease ◽  
Inhaled Corticosteroids ◽  
Population Based ◽  
Overlap Syndrome ◽  
Time Dependent ◽  
Research Database ◽  
Chronic Pulmonary Disease ◽  
Oral Steroids ◽  
Taiwan National Health Insurance ◽  
Study Participants

We investigated the effects of statins on tuberculosis (TB) and pneumonia risks in asthma–chronic pulmonary disease overlap syndrome (ACOS) patients. We extracted data of patients diagnosed as having ACOS during 2000–2010 from the Taiwan National Health Insurance Research Database and divided them into statin users and nonusers. All study participants were followed up from the index date until death, withdrawal from insurance, or TB and pneumonia occurred (31 December 2011). The cumulative TB and pneumonia incidence was analyzed using Cox proportional regression analysis with time-dependent variables. After adjustments for multiple confounding factors including age, sex, comorbidities, and use of medications [statins, inhaled corticosteroids (ICSs), or oral steroids (OSs)], statin use was associated with significantly lower TB [adjusted hazard ratio (aHR) 0.49, 95% confidence interval (CI) 0.34–0.70] and pneumonia (aHR 0.52, 95% CI 0.41–0.65) risks. Moreover, aHRs (95% CIs) for statins combined with ICSs and OSs were respectively 0.60 (0.31–1.16) and 0.58 (0.40–0.85) for TB and 0.61 (0.39–0.95) and 0.57 (0.45–0.74) for pneumonia. Thus, statin users had lower TB and pneumonia risks than did nonusers, regardless of age, sex, comorbidities, and ICS or OS use. Pneumonia risk was lower among users of statins combined with ICSs or Oss and TB risk was lower among the users of statins combined with OSs.

ADVERSE REACTIONS TO TETRACYCLINE, PENICILLIN AND AN OLEANDOMYCIN-PENICILLIN MIXTURE USED IN THE LONG-TERM THERAPY OF CHRONIC PULMONARY DISEASE

1962 ◽  
Vol 243 (3) ◽  
pp. 341-353 ◽  
Author(s):  
Solomon Sobel ◽  
Edward A. Lichter ◽  
J Calvin Davis ◽  
Harry F. Dowling ◽  
Mark H. Lepper ◽  
...  
Keyword(s):  
Pulmonary Disease ◽  
Adverse Reactions ◽  
Term Therapy ◽  
Chronic Pulmonary Disease ◽  
Long Term Therapy
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