Generalized Bone Changes and Thrombocytopenic Purpura in Association with Intrauterine Rubella

PEDIATRICS ◽  
1965 ◽  
Vol 36 (2) ◽  
pp. 264-268
Author(s):  
AARON R. RAUSEN ◽  
ROBERT D. LONDON ◽  
ABRAHAM MIZRAHI ◽  
LOUIS Z. COOPER
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Rubella Virus ◽  
Congenital Heart ◽  
Newborn Infants ◽  
First Trimester ◽  
Long Bones ◽  
Thrombocytopenic Purpura ◽  
Bone Changes ◽  
First Trimester Of Pregnancy

Two newborn infants are presented whose mothers had rubella in the first trimester of pregnancy. Both infants were born with thrombocytopenic purpura and suggestive evidence of a hemolytic disorder. The second infant had congenital heart disease as well. Roentgenographic changes in the metaphyseal ends of several long bones, observed in the first infant at 3 days of age, regressed completely by 2 months of age. The second infant had roentgenographic evidence of metaphyseal changes of a lesser degree, limited to the distal ends of the femora. These changes were no longer present at 6 weeks of age. Both infants were shown to be harboring an interfering agent with the characteristics of the rubella virus.

Seasonality in live births with congenital heart disease in Malta

1999 ◽  
Vol 9 (4) ◽  
pp. 396-401 ◽  
Author(s):  
Victor Grech
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Pulmonary Stenosis ◽  
First Trimester ◽  
Ventricular Septal Defects ◽  
Live Births ◽  
Septal Defects ◽  
First Trimester Of Pregnancy ◽  
Seasonal Analysis

AbstractThis study was carried out to analyse seasonal variations in live births with congenital heart disease in the overall population of Malta. Included were all patients diagnosed as having congenital heart disease by echocardiography, cardiac catheterization, surgery or post mortem, by 1 year of age, and who were born between in Malta between 1990 and 1994. Results were analysed by χ2 and by Edwards' cyclic method. There were 231 cases of live born congenital heart disease, which were divided into 114 cases not requiring intervention and 117 cases requiring intervention. Although the overall prevalence of congenital heart disease did not demonstrate any seasonal variation, the lesions requiring intervention showed a significant peak in September by Edwards' method (p = 0.03), which was enhanced by seasonal analysis (p = 0.003). These results were confirmed by conventional χ2 and χ2 for trend. The lesions not requiring intervention, which were comprised almost entirely (96%) of mild pulmonary stenosis and small ventricular septal defects, failed to show any seasonal trend. The literature regarding such seasonal trends in these malformations and statistical analysis of seasonality of congenital heart disease are reviewed. An environmental factor such as a maternal viral infection or treatment of such infections during the first trimester of pregnancy from November to January may precipitate congenital heart disease in predisposed Maltese foetuses.

scholarly journals Ultrasound Patterns in the First Trimester Diagnosis of Congenital Heart Disease

2021 ◽  
Vol 10 (15) ◽  
pp. 3206
Author(s):  
Catalin G. Herghelegiu ◽  
Anca Maria Panaitescu ◽  
Simona Duta ◽  
Ana Maria Vayna ◽  
Anca Marina Ciobanu ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Fetal Heart ◽  
Color Doppler ◽  
First Trimester ◽  
American Institute ◽  
Color Doppler Flow ◽  
First Trimester Of Pregnancy ◽  
And Child Health

Congenital heart disease (CHD) is the most common birth defect, with a reported prevalence of 5–12 per 1000 live births. Very recently, the American Institute of Ultrasound in Medicine published a guideline recommending the use of the four-chamber and the three-vessel and trachea views to screen for CHD in the first trimester of pregnancy. Our aim is to present abnormal image patterns that are seen in the four-chamber, three-vessel, and trachea views of the fetal heart in the first trimester and to describe their association with specific CHD types. We used a total of 29 cases of CHD from the archives of Filantropia Hospital and the Maternal and Child Health Institute (INSMC) fetal medicine units. We selected cases with a clear and well-documented diagnosis of the CHD type. We identified a series of repeating color doppler flow patterns seen in the four-chamber, three-vessel, and trachea views of the studied cases. Our observations could be developed into a diagnosis algorithm to orientate the examiner to the most likely type of CHD in individual cases.

GASTRIC RESPONSE TO SPECIFIC DISEASE IN INFANTS

PEDIATRICS ◽  
1966 ◽  
Vol 38 (5) ◽  
pp. 874-878
Author(s):  
Gordon B. Avery ◽  
Judson G. Randolph ◽  
Thomas Weaver
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Newborn Infants ◽  
Chloride Concentration ◽  
Acid Formation ◽  
Total Acidity ◽  
Pepsin Activity ◽  
Specific Disease ◽  
Normal Acidity

1. A method of gastric analysis has been developed for the study of newborn infants. Results obtained with this method have shown it to reflect more accurately the ongoing secretory activity of the stomach. Previous methods of sampling left significant and varying amounts of acidity behind in the stomach rendering much of the available data inconclusive. 2. For the first time, gastric function has been correlated with specific disease states in the infant. 3. The volume, pH, total acidity, chloride content, and pepsin activity have been found to vary independently of one another. 4. Pneumonia and bronchiolitis, two conditions producing compromised respiratory function, were characterized by decreased total acidity, a more alkaline pH, and decreased pepsin activity. 5. Infants with short gut after bowel resection displayed highly significant increases in total gastric acidity and rate of acid formation, and a lower gastric pH. 6. Infants with acyanotic congenital heart disease showed significantly decreased pepsin content and increased chloride concentration despite normal acidity. Conversely, the few infants with cyanotic congenital heart disease studied had decreased volume of gastric juice and rate of acid formation.

RESPIRATORY RATE, TIDAL VOLUME AND VENTILATION OF NEWBORN INFANTS IN THE PRONE AND SUPINE POSITIONS

PEDIATRICS ◽  
1961 ◽  
Vol 28 (3) ◽  
pp. 388-393
Author(s):  
W. T. Bruns ◽  
K. O. Loken ◽  
A. A. Siebens
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Tidal Volume ◽  
Respiratory Rate ◽  
Prone Position ◽  
Congenital Heart ◽  
Newborn Infants ◽  
Periodic Breathing ◽  
Continuous Recording ◽  
Body Plethysmograph

The respiratory rate, tidal volume and ventilation were measured in newborn infants with a body plethysmograph. A continuous recording revealed that, with one exception, no significant change occurred in these parameters when seven mature infants were turned from supine to prone position or vice versa. Two mature infants with periodic breathing, one of whom had congenital heart disease, exhibited periods of apnea when placed from the supine into the prone position.

Accelerated Idioventricular Rhythm in Three Newborn Infants With Congenital Heart Disease

CHEST Journal ◽  
1993 ◽  
Vol 104 (1) ◽  
pp. 322-323 ◽  
Author(s):  
Masao Nakagawa ◽  
Takao Yoshihara ◽  
Atsuko Matsumura ◽  
Touru Fusaoka ◽  
Kenji Hamaoka
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Newborn Infants ◽  
Idioventricular Rhythm
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