scholarly journals Ultrasound Patterns in the First Trimester Diagnosis of Congenital Heart Disease

2021 ◽  
Vol 10 (15) ◽  
pp. 3206
Author(s):  
Catalin G. Herghelegiu ◽  
Anca Maria Panaitescu ◽  
Simona Duta ◽  
Ana Maria Vayna ◽  
Anca Marina Ciobanu ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Fetal Heart ◽  
Color Doppler ◽  
First Trimester ◽  
American Institute ◽  
Color Doppler Flow ◽  
First Trimester Of Pregnancy ◽  
And Child Health

Congenital heart disease (CHD) is the most common birth defect, with a reported prevalence of 5–12 per 1000 live births. Very recently, the American Institute of Ultrasound in Medicine published a guideline recommending the use of the four-chamber and the three-vessel and trachea views to screen for CHD in the first trimester of pregnancy. Our aim is to present abnormal image patterns that are seen in the four-chamber, three-vessel, and trachea views of the fetal heart in the first trimester and to describe their association with specific CHD types. We used a total of 29 cases of CHD from the archives of Filantropia Hospital and the Maternal and Child Health Institute (INSMC) fetal medicine units. We selected cases with a clear and well-documented diagnosis of the CHD type. We identified a series of repeating color doppler flow patterns seen in the four-chamber, three-vessel, and trachea views of the studied cases. Our observations could be developed into a diagnosis algorithm to orientate the examiner to the most likely type of CHD in individual cases.

Generalized Bone Changes and Thrombocytopenic Purpura in Association with Intrauterine Rubella

PEDIATRICS ◽  
1965 ◽  
Vol 36 (2) ◽  
pp. 264-268
Author(s):  
AARON R. RAUSEN ◽  
ROBERT D. LONDON ◽  
ABRAHAM MIZRAHI ◽  
LOUIS Z. COOPER
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Rubella Virus ◽  
Congenital Heart ◽  
Newborn Infants ◽  
First Trimester ◽  
Long Bones ◽  
Thrombocytopenic Purpura ◽  
Bone Changes ◽  
First Trimester Of Pregnancy

Two newborn infants are presented whose mothers had rubella in the first trimester of pregnancy. Both infants were born with thrombocytopenic purpura and suggestive evidence of a hemolytic disorder. The second infant had congenital heart disease as well. Roentgenographic changes in the metaphyseal ends of several long bones, observed in the first infant at 3 days of age, regressed completely by 2 months of age. The second infant had roentgenographic evidence of metaphyseal changes of a lesser degree, limited to the distal ends of the femora. These changes were no longer present at 6 weeks of age. Both infants were shown to be harboring an interfering agent with the characteristics of the rubella virus.

scholarly journals Important roles of transesophageal color doppler flow mapping studies(TEE) in infants with congenital heart disease

1990 ◽  
Vol 15 (2) ◽  
pp. A204 ◽  
Author(s):  
David J. Sahn ◽  
Valdir Moises ◽  
Giovanni Cali ◽  
Lilliam M. Valdes-Cruz ◽  
William Massei ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Color Doppler ◽  
Flow Mapping ◽  
Doppler Flow ◽  
Color Doppler Flow

scholarly journals Analysis of commonly expressed genes between first trimester fetal heart and placenta cell types in the context of congenital heart disease

2022 ◽  
Author(s):  
Rebecca Wilson ◽  
Victor Yuan ◽  
Jennifer Alexander Courtney ◽  
Alyssa Tipler ◽  
James Cnota ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Endothelial Cells ◽  
Heart Disease ◽  
Congenital Heart ◽  
Fetal Heart ◽  
Reduction Process ◽  
Cell Types ◽  
First Trimester ◽  
Cellular Respiration ◽  
Oxidation Reduction

Congenital heart disease (CHD) is often associated with fetal growth abnormalities. During the first trimester of pregnancy, the heart and placenta develop concurrently, and share key developmental pathways. Hence, it is hypothesized that defective morphogenesis of either organ is synergistically linked. However, many studies determined to understand the mechanisms behind CHD overlook the contribution of the placenta. In this study, we aimed to identify commonly expressed genes between first trimester heart and placenta cells using two publicly available single cell sequencing databases. Using a systematic computational approach, we identified 328 commonly expressed genes between heart and placenta endothelial cells and enrichment in pathways including Vasculature Development (GO:0001944, FDR 2.90E-30), and Angiogenesis (GO:0001525, FDR 1.18E-27). We also found, in comparison with fetal heart endothelial cells, 197 commonly expressed genes with placenta extravillous trophoblasts, 128 with cytotrophoblasts and 80 with syncytiotrophoblasts, and included genes such as FLT1, GATA2, ENG and CDH5. Finally, comparison of first trimester cardiomyocytes and placenta cytotrophoblasts revealed 53 commonly expressed genes and enrichment in biological processes integral to cellular function including Cellular Respiration (GO:0045333; FDR 5.05E-08), Ion Transport (GO:0006811; FDR 2.08E-02), and Oxidation-Reduction Process (GO:0055114; FDR 1.58E-07). Overall, our results identify specific genes and cellular pathways common between first trimester fetal heart and placenta cells which if disrupted may concurrently contribute to the developmental perturbations resulting in CHD.

Seasonality in live births with congenital heart disease in Malta

1999 ◽  
Vol 9 (4) ◽  
pp. 396-401 ◽  
Author(s):  
Victor Grech
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Pulmonary Stenosis ◽  
First Trimester ◽  
Ventricular Septal Defects ◽  
Live Births ◽  
Septal Defects ◽  
First Trimester Of Pregnancy ◽  
Seasonal Analysis

AbstractThis study was carried out to analyse seasonal variations in live births with congenital heart disease in the overall population of Malta. Included were all patients diagnosed as having congenital heart disease by echocardiography, cardiac catheterization, surgery or post mortem, by 1 year of age, and who were born between in Malta between 1990 and 1994. Results were analysed by χ2 and by Edwards' cyclic method. There were 231 cases of live born congenital heart disease, which were divided into 114 cases not requiring intervention and 117 cases requiring intervention. Although the overall prevalence of congenital heart disease did not demonstrate any seasonal variation, the lesions requiring intervention showed a significant peak in September by Edwards' method (p = 0.03), which was enhanced by seasonal analysis (p = 0.003). These results were confirmed by conventional χ2 and χ2 for trend. The lesions not requiring intervention, which were comprised almost entirely (96%) of mild pulmonary stenosis and small ventricular septal defects, failed to show any seasonal trend. The literature regarding such seasonal trends in these malformations and statistical analysis of seasonality of congenital heart disease are reviewed. An environmental factor such as a maternal viral infection or treatment of such infections during the first trimester of pregnancy from November to January may precipitate congenital heart disease in predisposed Maltese foetuses.

Screening for congenital heart disease with the four-chamber view of the fetal heart

1992 ◽  
Vol 167 (4) ◽  
pp. 1000-1003 ◽  
Author(s):  
Patrizia Vergani ◽  
Silvana Mariani ◽  
Alessandro Ghidini ◽  
Riccardo Schiavina ◽  
Maria Cavallone ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Fetal Heart ◽  
Chamber View

scholarly journals Pattern of Congenital Heart Disease in Children Presenting at Paediatric Cardiology Unit in Chattagram Maa Shishu-O-General Hospital, Chittagong

2018 ◽  
Vol 16 (2) ◽  
pp. 40-43
Author(s):  
Sukhendu Shekhar Sen ◽  
Tanuka Barua ◽  
Dipika Dey ◽  
Mahmood A Chowdhury ◽  
Lutfan Nessa
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Early Detection ◽  
Congenital Heart ◽  
Septal Defect ◽  
Color Doppler ◽  
Mortality And Morbidity ◽  
Diagnostic Facility ◽  
Disease Pattern ◽  
Acyanotic Congenital Heart Disease

Background: Congenital Heart Disease (CHD) is the most common congenital problem in children. Early detection and proper management of congenital heart disease is very important to reduce mortality and morbidity. The purpose of this study was to find out the disease pattern of CHD among children in present situation in a center outside Dhaka.Methods: This study was conducted over a period from March 2016 to June 2017 prospectively and all patients with CHD was diagnosed by Color Doppler Echocardiography aging from 1st day of life to 12 years were included in the study.Results: Acyanotic CHD was most common among CHD. Atrial Septal Defect (ASD) was the commonest acyanotic congenital heart disease 100 (35.7 %) followed by Ventricular Septal Defect (VSD) 77 (27.5 %). Commonest cyanotic CHD was Tetralogy of Fallot (TOF) 9 (3.2 %). Only 25.36 % CHD were diagnosed during neonatal period whereas 54.64 % were diagnosed during the period of 29 days to completion of 12 months. Most of the patient (63.21%) were male.Conclusion: ASD was the commonest acyanotic CHD whereas TOF was the commonest cyanotic CHD. About 80% cases were diagnosed before 1 year of age. With the advancement of diagnostic facility and neonatal care, early detection of CHD is possible and treatment can be started at an earlier age.Chatt Maa Shi Hosp Med Coll J; Vol.16 (2); July 2017; Page 40-43

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