A LESSON ABOUT DRUNKARDS IN THE 1879 EDITION OF MCGUFFEY'S FIFTH ECLECTIC READER

PEDIATRICS ◽  
1978 ◽  
Vol 62 (1) ◽  
pp. 116-116
Author(s):  
T. E. C.
Keyword(s):  
Full Length ◽  
Young Reader ◽  
American Education ◽  
Human Being ◽  
Rocky Slope ◽  
Blue Eyes

Many have hailed the McGuffey Eclectic Readers as major influences not only in American education but in American morals and culture as well. It is estimated that 122,000,000 copies were sold between 1836 and 1920. A recurrent lesson in these Readers is the evils of drink. In the 1879 edition of the Fifth Reader, McGuffey chose this piece by John Greenleaf Whittier (1807-1892) to show the young reader the wretched effects of alcohol. . . . One fine morning, not long ago, I strolled down the Merrimac, on the Tewksbury shore. . . . The path winds, green and flower-skirted, among beeches and oaks, through whose boughs you catch glimpses of waters sparkling and dashing below. . . . Half fatigued with my walk, I threw myself down upon a rocky slope of the bank, where the panorama of earth, sky, and water lay clear and distinct about me. . . . Over all a warm but softened sunshine melted down from a slumberous autumnal sky. My revery was disagreeably broken. A low, grunting sound, half bestial, half human attracted my attention. I was not alone. Close beside me, half hidden by a tuft of bushes, lay a human being, stretched out at full length, with his face literally rooted into the gravel. A little boy, five or six years of age, clean and healthful, with his fair brown locks and blue eyes, stood on the bank above, gazing down upon him with an expression of childhood's simple and unaffected pity.

Looking at the Dark Sun: Aspects of Death, War and the Power of Stories in Markus Zusak and Terry Pratchett ’s Novels

Mousaion ◽  
2018 ◽  
Vol 35 (2) ◽  
pp. 28-40
Author(s):  
Dewald Mauritz Steyn
Keyword(s):  
Young Adult ◽  
Young Adult Literature ◽  
Young Reader ◽  
Human Being ◽  
Terry Pratchett

In this article, the author argues that Markus Zusak and Terry Pratchett make use of metafictional strategies as well as their respective anthropomorphic figures of death to allow readers, particularly young ones, to confront difficult topics, providing them with a glimpse of truth as far as their own mortality is concerned. In Zusak’s The Book Thief (2005) and Pratchett’s The Amazing Maurice and His Educated Rodents (2001), death, war and the nature of evil are considered through a fictional lens, allowing a certain amount of distancing between the young reader and these painful realities. Without naively underplaying the actuality of death, Zusak and Pratchett show how stories can ameliorate the traumatic and anxiety-inducing aspects of such events. Zusak challenges people’s notions of what young adult literature can portray, while Pratchett focuses on what it means not only to be a human being, but an ethical sentient being.

In Situ Localization of PPAR Gamma and Uncoupling Protein in Mouse Embryo Sections Using Digoxigenin-Labeled Riboprobes

1996 ◽  
Vol 54 ◽  
pp. 32-33
Author(s):  
C. Jennermann ◽  
S. A. Kliewer ◽  
D. C. Morris
Keyword(s):  
Alkaline Phosphatase ◽  
Room Temperature ◽  
Uncoupling Protein ◽  
Ppar Gamma ◽  
Nuclear Hormone Receptor ◽  
Full Length ◽  
Northern Analysis ◽  
Peroxisome Proliferator

Peroxisome proliferator-activated receptor gamma (PPARg) is a member of the nuclear hormone receptor superfamily and has been shown in vitro to regulate genes involved in lipid metabolism and adipocyte differentiation. By Northern analysis, we and other researchers have shown that expression of this receptor predominates in adipose tissue in adult mice, and appears first in whole-embryo mRNA at 13.5 days postconception. In situ hybridization was used to find out in which developing tissues PPARg is specifically expressed.Digoxigenin-labeled riboprobes were generated using the Genius™ 4 RNA Labeling Kit from Boehringer Mannheim. Full length PPAR gamma, obtained by PCR from mouse liver cDNA, was inserted into pBluescript SK and used as template for the transcription reaction. Probes of average size 200 base pairs were made by partial alkaline hydrolysis of the full length transcripts. The in situ hybridization assays were performed as described previously with some modifications. Frozen sections (10 μm thick) of day 18 mouse embryos were cut, fixed with 4% paraformaldehyde and acetylated with 0.25% acetic anhydride in 1.0M triethanolamine buffer. The sections were incubated for 2 hours at room temperature in pre-hybridization buffer, and were then hybridized with a probe concentration of 200μg per ml at 70° C, overnight in a humidified chamber. Following stringent washes in SSC buffers, the immunological detection steps were performed at room temperature. The alkaline phosphatase labeled, anti-digoxigenin antibody and detection buffers were purchased from Boehringer Mannheim. The sections were treated with a blocking buffer for one hour and incubated with antibody solution at a 1:5000 dilution for 2 hours, both at room temperature. Colored precipitate was formed by exposure to the alkaline phosphatase substrate nitrobluetetrazoliumchloride/ bromo-chloroindlylphosphate.

The Undercurrent of American Education

2003 ◽  
Vol 48 (4) ◽  
pp. 414-416
Author(s):  
Steven Stemler
Keyword(s):  
American Education

Pharmacokinetics of Full Length and Two-Domain Tissue Factor Pathway Inhibitor in Combination with Heparin in Rabbits

1993 ◽  
Vol 70 (03) ◽  
pp. 454-457 ◽  
Author(s):  
Claus Bregengaard ◽  
Ole Nordfang ◽  
Per Østergaard ◽  
Jens G L Petersen ◽  
Giorgio Meyn ◽  
...  
Keyword(s):  
Tissue Factor ◽  
Tissue Factor Pathway Inhibitor ◽  
Anticoagulant Activity ◽  
Fold Increase ◽  
Volume Of Distribution ◽  
Full Length ◽  
Heparin Binding ◽  
Extrinsic Pathway ◽  
C Terminus ◽  
Tissue Factor Pathway

SummaryTissue factor pathway inhibitor (TFPI) is a feed back inhibitor of the initial activation of the extrinsic pathway of coagulation. In humans, injection of heparin results in a 2-6 fold increase in plasma TFPI and recent studies suggest that TFPI may be important for the anticoagulant activity of heparin. Full length (FL) TFPI, but not recombinant two-domain (2D) TFPI, has a poly cationic C-terminus showing very strong heparin binding. Therefore, we have investigated if heparin affects the pharmacokinetics of TFPI with and without this C-terminus.FL-TFPI (608 U/kg) and 2D-TFPI (337 U/kg) were injected intravenously in rabbits with and without simultaneous intravenous injections of low molecular weight heparin (450 anti-XaU/kg).Heparin decreased the volume of distribution and the clearance of FL-TFPI by a factor 10-15, whereas the pharmacokinetics of 2D-TFPI were unaffected by heparin. When heparin was administered 2 h following TFPI the recovery of FL-TFPI was similar to that found in the group receiving the two compounds simultaneously, suggesting that the releasable pool of FL-TFPI is removed very slowly in the absence of circulating heparin.

Sign in / Sign up

Export Citation Format

Share Document