Repeated Naloxone Administration for Morphine Overdose in a 1-Month-Old Infant

PEDIATRICS ◽  
1979 ◽  
Vol 63 (4) ◽  
pp. 606-608
Author(s):  
Alan E. Gober ◽  
Gregory L. Kearns ◽  
Robert A. Yokel ◽  
Larry Danziger
Keyword(s):  
Adverse Effect ◽  
Cumulative Dose ◽  
Narcotic Antagonist ◽  
Naloxone Administration ◽  
Naloxone Hydrochloride ◽  
Apparent Adverse Effect

Repeated injections of naloxone hydrochloride, a pure narcotic antagonist, were administered to a 3,320-gm 4-week-old boy for treatment of an accidental morphine overdose. The infant received frequent naloxone hydrochloride injections (0.2 mg per injection) during the first 12 hours of therapy to reverse morphine-induced apnea, hypothermia, and flaccidity. A cumulative dose of 2.73 mg of naloxone hydrochloride (0.822 mg/kg) was administered over 27 hours without apparent adverse effect or evidence of toxicity.

Naloxone-Associated Patient Violence: An Overlooked Toxicity?

1992 ◽  
Vol 26 (2) ◽  
pp. 196-198 ◽  
Author(s):  
Gary M. Gaddis ◽  
William A. Watson
Keyword(s):  
Adverse Effect ◽  
Case Report ◽  
Respiratory Depression ◽  
Healthcare Workers ◽  
Violent Behavior ◽  
Healthcare Personnel ◽  
Naloxone Administration ◽  
Patient Violence ◽  
Public Safety Personnel ◽  
Unconscious Patients

OBJECTIVE: To report two cases of a previously unreported adverse effect, violent patient behavior, after the reversal of sedation by intravenous naloxone. DESIGN: Case report. PATIENTS/INTERVENTIONS: Responses of two individuals who had reversal of sedation by intravenous naloxone are compared. RESULTS: Placement of patient restraints before the administration of intravenous naloxone to obtunded or unconscious patients can make an important contribution to the safety of patients, healthcare personnel, and public safety personnel, as illustrated by the violent reaction of one unrestrained patient after naloxone administration. CONCLUSIONS: Patient restraint should be considered before naloxone administration to protect the patient and healthcare workers. In the prehospital setting, limiting the use of naloxone to patients with decreased mental status and respiratory depression would decrease the likelihood of naloxone-induced violent behavior.

Furosemide Abuse Without Apparent Adverse Effect

JAMA ◽  
1976 ◽  
Vol 235 (2) ◽  
pp. 146 ◽  
Author(s):  
Elliot J. Howard
Keyword(s):  
Adverse Effect ◽  
Apparent Adverse Effect

scholarly journals The biology and evolution of polyspermy: insights from cellular and functional studies of sperm and centrosomal behavior in the fertilized egg

Reproduction ◽  
2011 ◽  
Vol 142 (6) ◽  
pp. 779-792 ◽  
Author(s):  
Rhonda R Snook ◽  
David J Hosken ◽  
Timothy L Karr
Keyword(s):  
Adverse Effect ◽  
Reproductive Biology ◽  
Microtubule Dynamics ◽  
Taxonomic Distribution ◽  
Functional Studies ◽  
Fitness Consequences ◽  
Fertilized Egg ◽  
Apparent Adverse Effect

Recent studies of centrosome biogenesis, microtubule dynamics, and their management point to their role in mediating conditions such as aging and cancer. Centrosome dysfunction is also a hallmark of pathological polyspermy. Polyspermy occurs when the oocyte is penetrated by more than one sperm and can be pathological because an excess of centrosomes compromises development. However, in some taxa, multiple sperm enter the egg with no apparent adverse effect on zygote viability. Thus, some taxa can manage excess centrosomes and represent cases of non-pathological polyspermy. While these two forms of polyspermy have long been known, we argue that there is limited understanding of the proximate and ultimate processes that underlie this taxonomic variation in the outcome of polyspermy and that studying this variation could help uncover the control and role(s) of centrosomes during fertilization in particular, but also mitosis in general. To encourage such studies we: 1) describe taxonomic differences in the outcome of polyspermy, 2) discuss mechanistic aspects of reproductive biology that may contribute to the different consequences of polyspermy, and 3) outline the potential selective events that could lead to the evolution of variation in polyspermy outcomes. We suggest that novel insights into centrosome biology may occur by cooperative studies between reproductive and evolutionary biologists focusing on the mechanisms generating variation in the fitness consequences of polyspermy, and in the taxonomic distribution of all these events. The consequent discoveries of these studies may lead to informative insights into cancer and aging along with other centrosome-related diseases and syndromes.

Endophytic Fungi as a reservoir of Lignocellulolytic Enzymes- A Review

2021 ◽  
Vol 16 (11) ◽  
pp. 134-140
Author(s):  
Ram Kumar Pundir ◽  
Pranay Jain
Keyword(s):  
Adverse Effect ◽  
Natural Products ◽  
Enzymatic Activity ◽  
Endophytic Fungi ◽  
Present Status ◽  
Lignocellulolytic Enzymes ◽  
Agricultural Industries ◽  
Potential Use ◽  
Apparent Adverse Effect

The potential use of microorganisms as biotechnological sources of industrially important enzymes has stimulated interest in exploration of extracellular enzymatic activity in several microorganisms. Endophytic fungi are those fungi which colonize plants internally without apparent adverse effect. Endophytic fungi are relatively unexplored producers of metabolites useful to pharmaceutical and agricultural industries. As a result, the role of endophytes in production of various natural products with greater bioactivity has received increased attention. Endophytic fungi have been found to degrade lignocellulose consisting of lignin, cellulose and hemicellulose with the aid of lignocellulases enzynes. This review highlights the potential of endophytic fungi for production of lignocellulases and also discusses the present status and future prospectives in this field.

Letter: Furosemide abuse without apparent adverse effect

JAMA ◽  
1976 ◽  
Vol 235 (2) ◽  
pp. 146b-146 ◽  
Author(s):  
E. J. Howard
Keyword(s):  
Adverse Effect ◽  
Apparent Adverse Effect

scholarly journals THE EFFECT OF CHLORDANE AND THIRAM ON DAMPING-OFF AND SEEDLING GROWTH

1961 ◽  
Vol 37 (3) ◽  
pp. 211-216 ◽  
Author(s):  
J. Cockerill
Keyword(s):  
Adverse Effect ◽  
Seedling Growth ◽  
Root Development ◽  
Red Pine ◽  
Damping Off ◽  
White Grub ◽  
Seedling Mortality ◽  
Apparent Adverse Effect

Chlordane, applied to seed beds of red pine to control white grub infestation, increased seedling mortality due to damping-off in these beds. Losses were significantly reduced when the seed was pelleted with thiram prior to sowing. Neither chlordane nor thiram, alone or in combination, had any apparent adverse effect on seedling growth, root development, or the formation of mycorrhiza.

Two Cases of Agranulocytosis on Addition of a Butyrophenone to a Long-Standing Course of Phenothiazine Treatment

1989 ◽  
Vol 154 (5) ◽  
pp. 710-712 ◽  
Author(s):  
Allan Young ◽  
Robert Kehoe
Keyword(s):  
Adverse Effect ◽  
Cumulative Dose ◽  
Previous Exposure ◽  
Prolonged Administration ◽  
First Time ◽  
The Relationship

Two cases of agranulocytosis occurring after addition of a butyrophenone to a course of phenothiazine treatment are reported and possible mechanisms for this interaction are discussed. Agranulocytosis is a well-documented adverse effect of phenothiazine administration (Vincent, 1986). Important factors are the total amount of drug given and the duration of administration. Agranulocytosis usually occurs within the first three months of therapy (Pisciotta, 1971; Marcus & Mulvihill, 1978) and the relationship with the cumulative dose has been emphasised (Ananth et al, 1973). Agranulocytosis following prolonged administration has been rarely reported (Denber, 1970, Pisciotta, 1978). We report two cases where agranulocytosis developed in patients with a long previous exposure to phenothiazines, treated for the first time with a combination of phenothiazines and a butyrophenone.

scholarly journals Ototoxicity, a rare but reversible adverse effect of a commonly used antimicrobial agent

2019 ◽  
Vol 12 (7) ◽  
pp. e230251 ◽  
Author(s):  
Pawan Kumar Singh ◽  
Vishal Sharma
Keyword(s):  
Adverse Effect ◽  
Hearing Loss ◽  
Cumulative Dose ◽  
Serological Test ◽  
Dramatic Improvement ◽  
Haemophagocytic Lymphohistiocytosis ◽  
Mixed Hearing Loss ◽  
Rare Manifestation ◽  
Before And After ◽  
Objective Improvement

In this case report, we describe a rare manifestation of amphotericin B (AMB) toxicity. A case of fever, hepato-splenomegaly and pancytopenia was diagnosed, based on serological test and demographic profile, as visceral leishmaniasis complicated with secondary haemophagocytic lymphohistiocytosis. He was managed with conventional AMB. Subsequently, patient was showing subjective and objective improvement. Suddenly after receiving 450 mg of cumulative dose of AMB, patient developed hearing loss. On evaluation, he was found to have bilateral mixed hearing loss. Patient was investigated for the causes of hearing loss. When nothing could be attributed as an aetiology, AMB was stopped (after 500 mg cumulative dose). After missing the dose of AMB, patient had a dramatic improvement in his sense of hearing, which was confirmed objectively by audiometry before and after the event.

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