scholarly journals Dyslipidemia in patients with arterial hypertension and extrasystoles

2016 ◽  
Vol 7 (2) ◽  
pp. 73-77
Author(s):  
N. V. Didyc
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Diastolic Dysfunction ◽  
Pressure Profile ◽  
Ventricular Volume ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Clinical Group ◽  
Hypertensive Disease ◽  
Functional Changes

The significant incidence of hypertensive disease among the Ukrainian population makes the search for new methods of management and treatment of patients suffering from this pathology a matter of high priority. Our research is focused on study of changes of some biochemical parameters in patients suffering from hypertensive disease as well as patients suffering from hypertensive disease and coexistent extrasystoles. Arterial hypertension leads to different structural and functional changes in the cardiovascular system. In many patients these changes may result in rhythm disorders. 120 patients have been examined (42 men and 78 women) between the ages of 27 to 81 (average 59.8) suffering from hypertensive disease of the II stage as defined by the Ukrainian Association of Cardiologists and from extrasystoles (more than 30 episodes per hour of research) of different topography and 30 persons (13 men and 17 women) suffering from hypertensive disease of the II stage between the ages 30 to 76 (average 56.4) without rhythm disturbance). The first clinical group was formed by 54 (45%) patients suffering from repeated supraventricular extrasystoles (SE) (average 62 ± 2 SE per hour of research). The second clinical group was formed by 42 (35%) patients suffering from repeated ventricular arhythmia (VA) (average 37 ± 2 VA per hour of research). The third group was formed by 24 (20%) patients suffering from both repeated SE and VA (average 48 ± 3 SE and 32 ± 3 VA per hour of research). We conducted 24 hours’ monitoring of blood pressure and electrocardiography using the “Dia Card”-system (“Solvaig”, Ukraine) for all patients. This revealed that ventricle extrasystoles and combined extrasystoles in patients with essential hypertension, II stage are associated with more unfavourable changes in 24 hours’ profile of blood pressure. The paper analyses the cardiac arhythmia structure of heart rate variability in patients with arterial hypertension (AH) and extrasystoles. The findings confirmed the presence of desynchronization in the activity of the neurohnmoral system. Thus, different mechanisms of arhythmogenesis were revealed in patients with arterial hypertension. In the results, frequent ventricular and combined extrasystoles were associated with an unfavourable blood pressure profile during 24-hours monitoring as well as higher end-diastolic left ventricular volume, diastolic dysfunction, aortic valve fibrosis, aorta remodeling, endothelial dysfunction and more prominent lipid disorders. Supraventricular extrasystoles were associated with hypertriglyceridemia, left ventricular diastolic dysfunction and left atrium enlargement. 

scholarly journals CIRCADIAN BLOOD PRESSURE PROFILE AND LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN CHRONIC PROSTATITIS

2013 ◽  
Vol 19 (2) ◽  
pp. 171-177
Author(s):  
D. N. Zaytsev
Keyword(s):  
Blood Pressure ◽  
Diastolic Dysfunction ◽  
Chronic Prostatitis ◽  
Pressure Profile ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Circadian Blood Pressure ◽  
Blood Pressure Profile ◽  
Ventricular Diastolic Dysfunction ◽  
Circadian Blood Pressure Profile

Objective.To study the relationship between diastolic left ventricular dysfunction and the circadian bloodpressure prof le in patients with chronic prostatitis.Design and methods.Eighty-two patients with chronic prostatitis underwent ambulatory blood pressure monitoring and echocardiography.Results and conclusion.The disturbances of circadian blood pressure profile in patients with chronic prostatitis include the abnormal nocturnal decrease in systolic and/or diastolic blood pressure, instable nocturnal systolic hypertension and an abnormality of the morning blood pressure surge. In patients with abnormal circadian blood pressure profile left ventricular diastolic dysfunction with increased myocardial mass and thickness of the posterior wall of the left ventricle was more prevalent.

scholarly journals The Capabilities of Amlodipine/Lisinopril Single-Pill Combination in the Treatment of Newly Diagnosed Arterial Hypertension in a Middle-Aged Patient (Case Report)

2020 ◽  
Vol 16 (2) ◽  
pp. 221-230
Author(s):  
A. I. Kochetkov ◽  
M. V. Lopukhina ◽  
E. A. Kotaeva ◽  
A. A. Kirichenko ◽  
O. D. Ostroumova
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Left Ventricular ◽  
Favorable Effect ◽  
Newly Diagnosed ◽  
Functional Changes ◽  
Collagen Formation ◽  
Cardiovascular Morbidity And Mortality ◽  
Single Pill ◽  
Left Atrial Stiffness

Arterial hypertension (AH) is one of the most significant modifiable risk factors that increase cardiovascular morbidity and mortality worldwide, including Russia. The complex of structural and functional changes in the heart that occurs during AH consists not only in the formation of left ventricular (LV) myocardial hypertrophy, but also in the myocardial stiffness increasing due to collagen formation and cardiomyocytes apoptosis. These abnormalities are substrate for diastolic function disturbances, electrical myocardial instability and ischemia. The article provides a clinical case of amlodipine/lisinopril single-pill combination (A/L SPC) use in real clinical practice in a patient with stage II grade 2 newly diagnosed AH and its effect on blood pressure and echocardiographic myocardial fibrosis markers, including speckle tracking parameters The high antihypertensive efficacy of A/L SPC, a favorable effect on blood pressure circadian rhythm, as well as pronounced target-organ protective properties, in particular the ability to reduce LV and left atrial stiffness, were demonstrated. So, we conclude that A/L SPC improve the elastic properties of the left heart.

scholarly journals Microalbuminuria as a Marker of Preclinical Diastolic Dysfunction in Newly Diagnosed and Never-Treated Essential Hypertension

2013 ◽  
Vol 35 (1) ◽  
pp. 3-8
Author(s):  
RM Gajurel ◽  
A Sayami
Keyword(s):  
Essential Hypertension ◽  
Diastolic Dysfunction ◽  
Myocardial Dysfunction ◽  
Public Health Problem ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Newly Diagnosed ◽  
Spot Urine ◽  
Functional Changes ◽  
Ventricular Diastolic Dysfunction

Introduction: Hypertension (HTN) is a global public health problem with one fourth adults worldwide estimated to have high blood pressure (BP)1 The incidence of hypertension continues to increase in all developed and developing societies as the population grows older and more obese. The Framingham Study and other epidemiological surgeys have clearly defined HTN as an important cause of morbidity and mortality. The aim of this study was to determine the spot urine Microalbuminuria as a marker of preclinical cardiac structural and functional changes in the form of left ventricular diastolic dysfunction in newly diagnosed and never treated essential hypertensive subjects. Methods: A cross sectional study was used for those patients who were attended outpatient clinic of MCVTC with diagnosis of newly diagnosed and never treated hypertension over a period of October 2011 to November 2012. Results: A total of 130 essential hypertensive patients underwent for spot urine for microalbuminuria estimation and Echocardiography for evaluation of left ventricular diastolic function. Among 56 (43.1%) urine samples showed negative test [(Microalbuminuria -); ( UACR 30 mg/Gm)] and those 74 (56.9%) samples revealed positive test [(Microalbuminuria+); (UACR 30 to 300 mg/Gm)]. Patients with microalbuminuria positive was found to have more left ventricular diastolic dysfunction than those who were negative for Microalbuminuria. Conclusion: Microalbuminuria was found to have early preclinical marker of myocardial dysfunction in the form of left ventricular diastolic dysfunction in new and never treated essential hypertension. DOI: http://dx.doi.org/10.2126/joim.v35i1.8890  Journal of Institute of Medicine, April, 2013; 35:3-8

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