PATHOGENESIS ASPECTS OF FORMATION OF THE DISADAPTATION CHANGES OF CARDIOVASCULAR SYSTEM, COURSED BY INTENSIVE PHYSICAL ACTIVITIES

2016 ◽  
Vol 26 (3) ◽  
pp. 336-348
Author(s):  
Larisa A. Balykova ◽  
◽  
Stanislav A. Ivyanskiy ◽  
Yelena V. Gromova ◽  
Kristina A. Varlashina ◽  
...  
Author(s):  
I. M. Uneze ◽  
D. N. Azionu ◽  
A. S. Ogunbowale

Antibiotics have been reported to produce varied degree of toxicity to different organs and systems. Thus, the present study investigated the effect of Norbactin on the lipid profile of the cardiovascular system of Albino rats. The research was performed on 20 adult male Albino rats, randomly placed in 5 groups (A,B,C,D,E) of 4 rats in each. Group A,B,C,D were administrated 5.72,11.43,17.15 and 22.86(mg/kg) respectively of Norbactin solution. Group E was the control. The administration was by oral intubation and lasted for 7 consecutive days. Physical activities, feed and water intake was found to decrease in the test groups while the control did not show significant (p>0.05) changes. Concentration of total cholesterol, triglyceride and low density lipoprotein in the groups administered the drug was significantly (p>0.05) higher than the control. The level of high density lipoprotein recorded in group A,B,C and D was significantly (p<0.05) lower than in the control. This effect were found to be dose dependent. The findings of this study suggest that Norbactin may be toxic to the cardiovascular system. It may not be suitable for a patient with cardiovascular disorders.


2020 ◽  
Vol 134 (17) ◽  
pp. 2243-2262
Author(s):  
Danlin Liu ◽  
Gavin Richardson ◽  
Fehmi M. Benli ◽  
Catherine Park ◽  
João V. de Souza ◽  
...  

Abstract In the elderly population, pathological inflammation has been associated with ageing-associated diseases. The term ‘inflammageing’, which was used for the first time by Franceschi and co-workers in 2000, is associated with the chronic, low-grade, subclinical inflammatory processes coupled to biological ageing. The source of these inflammatory processes is debated. The senescence-associated secretory phenotype (SASP) has been proposed as the main origin of inflammageing. The SASP is characterised by the release of inflammatory cytokines, elevated activation of the NLRP3 inflammasome, altered regulation of acetylcholine (ACh) nicotinic receptors, and abnormal NAD+ metabolism. Therefore, SASP may be ‘druggable’ by small molecule therapeutics targeting those emerging molecular targets. It has been shown that inflammageing is a hallmark of various cardiovascular diseases, including atherosclerosis, hypertension, and adverse cardiac remodelling. Therefore, the pathomechanism involving SASP activation via the NLRP3 inflammasome; modulation of NLRP3 via α7 nicotinic ACh receptors; and modulation by senolytics targeting other proteins have gained a lot of interest within cardiovascular research and drug development communities. In this review, which offers a unique view from both clinical and preclinical target-based drug discovery perspectives, we have focused on cardiovascular inflammageing and its molecular mechanisms. We have outlined the mechanistic links between inflammageing, SASP, interleukin (IL)-1β, NLRP3 inflammasome, nicotinic ACh receptors, and molecular targets of senolytic drugs in the context of cardiovascular diseases. We have addressed the ‘druggability’ of NLRP3 and nicotinic α7 receptors by small molecules, as these proteins represent novel and exciting targets for therapeutic interventions targeting inflammageing in the cardiovascular system and beyond.


2014 ◽  
Vol 62 (S 01) ◽  
Author(s):  
M. Sigler ◽  
S. Huell ◽  
R. Foth ◽  
W. Ruschewski ◽  
T. Tirilomis ◽  
...  

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