scholarly journals Application of a New Method of Noninvasive Aassessment of Carbohydrate Metabolism Disorders in the Population Screening

2020 ◽  
Vol 32 (5) ◽  
pp. 121-130
Author(s):  
Andrey Aleksandrovich Berezin ◽  
Roman Sergeevich Novikov ◽  
Maxim Aleksandrovich Novopashin ◽  
Boris Aronovich Pozin ◽  
Alexander Viktorovich Shmid

Method for conducting a non-invasive screening of the population for carbohydrate metabolism disorders (CMD) has been developed and described. The novelty of the method is that there are no medical standards in the field of endocrinology for the non-invasive type of screening, so the method was based on the results of a clinical study of electrocardiographic abnormalities in patients with CMD, where the method of non-invasive determination of CMD by first-lead ECG was used. During the development of the method, an additional analysis of the ECG sample obtained during the study was performed. As a result of the analysis, it was concluded that the effectiveness of the method (sensitivity and specificity) vary slightly depending on the time of taking an ECG during the day. This means that the patient can come to the screening using the new method of non-invasive detection of CMD not only in the morning and not necessarily on an empty stomach, in contrast to the invasive methods (fasting plasma glucose test and oral glucose tolerance test). To make a decision «there is a suspicion of CMD /there is no suspicion of CMD», the patient only needs to take up to 2 ECGs.

1971 ◽  
Vol 67 (2) ◽  
pp. 277-287 ◽  
Author(s):  
E. Nieschlag ◽  
B. Wördehoff ◽  
H. J. Gilfrich ◽  
J. Michaelis ◽  
C. Overzier

ABSTRACT The influence of antithyroid therapy on the abnormalities of carbohydrate metabolism observed in hyperthyroidism was investigated in 10 patients. No history of diabetes mellitus was known in the patients or their families. 9 normal persons were taken as a control group. An oral and an intravenous glucose tolerance test were administered prior to and at intervals of 2 and 4 weeks after initiation of therapy. Prior to treatment an inpairment of oral glucose tolerance was observed, whereas the glucose assimilation coefficient in the intravenous glucose tolerance test was normal. Both tests however, revealed a significant rise in insulin values above normal. 2 weeks after initiation of therapy insulin values returned to normal during the intravenous glucose tolerance test. During the oral glucose tolerance test glucose and insulin concentration achieved normal levels only after 4 weeks of treatment. In all patients the abnormalities of carbohydrate metabolism observed were reversible.


2004 ◽  
Vol 29 (1) ◽  
pp. 33-36 ◽  
Author(s):  
Dai WATANABE ◽  
Hiromi NAKARA ◽  
Keisuke AKAGI ◽  
Toshiya ISHII ◽  
Hiroyasu MIZUGUCHI ◽  
...  

Author(s):  
Govindasami Chandirasegaran ◽  
Chakkaravarthy Elanchezhiyan ◽  
Kavisa Ghosh ◽  
Subramaniyan Sethupathy

2019 ◽  
Author(s):  
Mehmet Yaprak ◽  
Raziye Şule Gümüştakım ◽  
Abdullah Tok ◽  
Adem Doğaner

1966 ◽  
Vol 34 (3) ◽  
pp. 289-298 ◽  
Author(s):  
I. M. D. JACKSON ◽  
K. D. BUCHANAN ◽  
M. T. McKIDDIE ◽  
C. R. M. PRENTICE

SUMMARY An oral glucose tolerance test was performed in eight patients with gonadal dysgenesis and in two a diabetic response was found. The plasma insulin levels were estimated in response to the glucose load and were abnormal in five out of the six patients examined. The blood sugar response to the standard insulin tolerance test was normal in six patients and showed increased insulin sensitivity in two. Plasma cortisol concentration was measured in response to the hypoglycaemia induced by insulin and in seven out of the eight patients rose considerably indicating a normally functioning pituitary-adrenal system. The sera of all eight patients were examined for auto-antibodies and were essentially negative. Possible reasons for the abnormalities in carbohydrate metabolism are discussed and it is suggested that gonadal dysgenesis may predispose to diabetes.


Pituitary ◽  
2011 ◽  
Vol 15 (4) ◽  
pp. 466-471 ◽  
Author(s):  
Laura Boero ◽  
Marcos Manavela ◽  
Karina Danilowicz ◽  
Analia Alfieri ◽  
Maria Carolina Ballarino ◽  
...  

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