CARBOHYDRATE METABOLISM AND PITUITARY FUNCTION IN GONADAL DYSGENESIS (TURNER'S SYNDROME)

1966 ◽  
Vol 34 (3) ◽  
pp. 289-298 ◽  
Author(s):  
I. M. D. JACKSON ◽  
K. D. BUCHANAN ◽  
M. T. McKIDDIE ◽  
C. R. M. PRENTICE
Keyword(s):  
Carbohydrate Metabolism ◽  
Gonadal Dysgenesis ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Plasma Cortisol Concentration ◽  
Adrenal System ◽  
Insulin Tolerance ◽  
Plasma Insulin Levels ◽  
Blood Sugar Response

SUMMARY An oral glucose tolerance test was performed in eight patients with gonadal dysgenesis and in two a diabetic response was found. The plasma insulin levels were estimated in response to the glucose load and were abnormal in five out of the six patients examined. The blood sugar response to the standard insulin tolerance test was normal in six patients and showed increased insulin sensitivity in two. Plasma cortisol concentration was measured in response to the hypoglycaemia induced by insulin and in seven out of the eight patients rose considerably indicating a normally functioning pituitary-adrenal system. The sera of all eight patients were examined for auto-antibodies and were essentially negative. Possible reasons for the abnormalities in carbohydrate metabolism are discussed and it is suggested that gonadal dysgenesis may predispose to diabetes.

KOHLENHYDRATSTOFFWECHSEL BEI HYPERTHYREOSE: EINFLUSS EINER THYREOSTATISCHEN THERAPIE AUF ORALE UND INTRAVENÖSE GLUCOSETOLERANZ UND INSULINAKTIVITÄT

1971 ◽  
Vol 67 (2) ◽  
pp. 277-287 ◽  
Author(s):  
E. Nieschlag ◽  
B. Wördehoff ◽  
H. J. Gilfrich ◽  
J. Michaelis ◽  
C. Overzier
Keyword(s):  
Glucose Tolerance ◽  
Carbohydrate Metabolism ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Intravenous Glucose Tolerance Test ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Intravenous Glucose ◽  
Intravenous Glucose Tolerance ◽  
Initiation Of Therapy

ABSTRACT The influence of antithyroid therapy on the abnormalities of carbohydrate metabolism observed in hyperthyroidism was investigated in 10 patients. No history of diabetes mellitus was known in the patients or their families. 9 normal persons were taken as a control group. An oral and an intravenous glucose tolerance test were administered prior to and at intervals of 2 and 4 weeks after initiation of therapy. Prior to treatment an inpairment of oral glucose tolerance was observed, whereas the glucose assimilation coefficient in the intravenous glucose tolerance test was normal. Both tests however, revealed a significant rise in insulin values above normal. 2 weeks after initiation of therapy insulin values returned to normal during the intravenous glucose tolerance test. During the oral glucose tolerance test glucose and insulin concentration achieved normal levels only after 4 weeks of treatment. In all patients the abnormalities of carbohydrate metabolism observed were reversible.

HYPOTHALMIC-PITUITARY ADRENAL RESPONSIVENESS TO DEXAMETHASONE-INSULIN TOLERANCE TEST IN ACROMEGALIC PATIENTS BEFORE AND DURING TREATMENT WITH BROMOCRIPTINE

1978 ◽  
Vol 88 (1) ◽  
pp. 18-22 ◽  
Author(s):  
A. D. B. Harrower ◽  
N. McD. Davidson ◽  
P. L. Yap ◽  
I. M. Nairn ◽  
J. A. Fyffe ◽  
...  
Keyword(s):  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Insulin Tolerance Test ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Plasma Growth Hormone ◽  
Insulin Tolerance ◽  
Basal Plasma ◽  
The Mean ◽  
Plasma Gh

ABSTRACT Insulin tolerance tests were carried out in 10 acromegalic patients after 1 mg dexamethasone had been given the previous evening (DEX-ITT). Nine patients showed a rise in plasma 11-OHCS and four patients showed a rise in plasma growth hormone (GH) levels. These responses were unaltered after treatment with bromocriptine 10 mg daily for two months. Basal plasma GH levels fell in 6 of the patients and the mean plasma GH levels of the 10 patients during an oral glucose tolerance test (OGTT) fell from 63.2 ± 25.5 ng/ml before treatment to 53.0 ± 27.1 ng/ml (mean ± sem; P < 0.05). These data fail to confirm a previous report of abnormal hypothalmic-pituitary-adrenal suppressibility during a DEX-ITT in acromegalic patients. They also indicate that bromocriptine does not alter the responses of plasma 11-OHCS and plasma GH to the DEX-ITT despite lowering plasma GH levels.

scholarly journals Application of a New Method of Noninvasive Aassessment of Carbohydrate Metabolism Disorders in the Population Screening

2020 ◽  
Vol 32 (5) ◽  
pp. 121-130
Author(s):  
Andrey Aleksandrovich Berezin ◽  
Roman Sergeevich Novikov ◽  
Maxim Aleksandrovich Novopashin ◽  
Boris Aronovich Pozin ◽  
Alexander Viktorovich Shmid
Keyword(s):  
Carbohydrate Metabolism ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
New Method ◽  
Oral Glucose ◽  
Non Invasive ◽  
Medical Standards ◽  
Glucose Test ◽  
Electrocardiographic Abnormalities

Method for conducting a non-invasive screening of the population for carbohydrate metabolism disorders (CMD) has been developed and described. The novelty of the method is that there are no medical standards in the field of endocrinology for the non-invasive type of screening, so the method was based on the results of a clinical study of electrocardiographic abnormalities in patients with CMD, where the method of non-invasive determination of CMD by first-lead ECG was used. During the development of the method, an additional analysis of the ECG sample obtained during the study was performed. As a result of the analysis, it was concluded that the effectiveness of the method (sensitivity and specificity) vary slightly depending on the time of taking an ECG during the day. This means that the patient can come to the screening using the new method of non-invasive detection of CMD not only in the morning and not necessarily on an empty stomach, in contrast to the invasive methods (fasting plasma glucose test and oral glucose tolerance test). To make a decision «there is a suspicion of CMD /there is no suspicion of CMD», the patient only needs to take up to 2 ECGs.

A double-blind cross-over study on the effects of ORG OD14 compared to oestradiol valerate and placebo on lipid and carbohydrate metabolism in oophorectomized women

1983 ◽  
Vol 102 (3) ◽  
pp. 451-455 ◽  
Author(s):  
N. Crona ◽  
G Silfverstolpe ◽  
G. Samsioe
Keyword(s):  
Glucose Tolerance ◽  
Carbohydrate Metabolism ◽  
Glucose Tolerance Test ◽  
Marked Decrease ◽  
Clinical Stage ◽  
Density Lipoprotein ◽  
Tolerance Test ◽  
Continuous Treatment ◽  
Oral Glucose ◽  
Double Blind

Abstract. ORG OD14 is a synthetic steroid which in traditional bioassays has been shown to have oestrogenic and progestogenic as well as very weak androgenic-anabolic properties. As judged from earlier studies, this steroid seems suitable for continuous treatment of climacteric deficiency symptoms. The aim of this study was to evaluate the effects induced by OD14 on lipid, lipoprotein and carbohydrate metabolism, as compared to E2V and placebo. Twenty-two women, oophorectomized as part of the treatment of cervical carcinoma in clinical stage IB or IIA, were given ORG OD14 2.5 mg/day, oestradiol valerate (E2V) 2 mg/day and a placebo for 6 weeks each, in a double-blind cross-over study. There was a marked decrease in all lipid components of HDL (high density lipoprotein), i.e. total and free cholesterol, triglycerides and phospholipids (P < 0.001), after OD14. The oral glucose tolerance test showed higher values after OD14 compared to both E2V and placebo (P < 0.05), indicating a slightly impaired glucose tolerance. The lipid metabolic changes induced by OD14 indicate a rather strong androgenic influence in this respect.

Abstract #873: Association of Patterns in the Oral Glucose Tolerance Test and Different Clinical Features in Patients with Insulinoma

2005 ◽  
Vol 11 ◽  
pp. 28
Author(s):  
Fanny Rodriguez Vallejo ◽  
Juan Manuel Rios Torres ◽  
Francisco J. Gomez-Pérez ◽  
Juan A. Rull Rodrigo ◽  
Bernardo Pérez Enriquez
Keyword(s):  
Glucose Tolerance ◽  
Oral Glucose Tolerance Test ◽  
Clinical Features ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Oral Glucose Tolerance
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