scholarly journals Acute pancreatitis in IgA vasculitis

2021 ◽  
Vol 17 (2) ◽  
pp. 164-167
Author(s):  
Anna Fedorczak ◽  
◽  
Dorota Szałowska-Woźniak ◽  
Krzysztof Zeman ◽  
◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Abdominal Pain ◽  
Gastrointestinal Tract ◽  
Blood Vessels ◽  
Clinical Manifestation ◽  
Systemic Vasculitis ◽  
Pancreatic Enzymes ◽  
Iga Vasculitis ◽  
Abdominal Symptoms ◽  
Schonlein Purpura

IgA vasculitis, also known as the Henoch–Schönlein purpura, is the most common systemic vasculitis in children. Inflammation most often involves small blood vessels of the skin, joints, kidneys and the gastrointestinal tract, but other organs may also be involved. Acute pancreatitis is a rare clinical manifestation of IgA vasculitis. We present a case of a 12-year-old girl with cutaneous and abdominal symptoms, who was diagnosed with acute pancreatitis during IgA vasculitis. In patients with IgA vasculitis who report abdominal pain acute pancreatitis should be taken into account and pancreatic enzymes measurement should be considered.

scholarly journals Meningismus in IgA vasculitis (Henoch–Schönlein purpura)

2020 ◽  
Vol 16 (4) ◽  
pp. 414-417
Author(s):  
Katarzyna Gmachowska ◽  
Keyword(s):  
Abdominal Pain ◽  
Disease Duration ◽  
Systemic Vasculitis ◽  
Symptomatic Treatment ◽  
Acute Onset ◽  
Neurological Symptoms ◽  
Meningococcal Sepsis ◽  
Iga Vasculitis ◽  
Meningeal Irritation ◽  
Schonlein Purpura

IgA vasculitis is the most common acute systemic vasculitis in children. Typical symptoms include cutaneous purpura not associated with thrombocytopenia, acute-onset abdominal pain, arthritis, renal symptoms and, less commonly, neurological symptoms. The disease is usually mild and self-limiting. Although the aetiology of IgA vasculitis is unknown, autoimmune involvement is suspected. Symptomatic treatment is mainly used; therapeutic method that would reduce disease duration and prevent recurrence is unknown. Meningococcal sepsis should always be ruled out in a child with cutaneous purpura. We present a case of a 4-year-old boy with IgA vasculitis who developed symptoms of meningeal irritation.

scholarly journals HENOCH-SCHÖNLEIN PURPURA Z NEZNAČILNIM POTEKOM BOLEZNI – predstavitev treh primerov in pregled literature

2016 ◽  
Vol 85 (2) ◽  
Author(s):  
Daša Kumprej ◽  
Tomaž Krenčnik ◽  
Aleksandra Aleksandrova Oberstar ◽  
Nataša Toplak
Keyword(s):  
Abdominal Pain ◽  
Renal Disease ◽  
Blood Vessels ◽  
Current Literature ◽  
Atypical Presentation ◽  
Disease Course ◽  
Henoch Schonlein Purpura ◽  
Skin Manifestation ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Background: Henoch-Schönlein purpura is the most common vasculitis of small blood vessels in children. The diagnosis of the disease is confirmed in a patient with a specific rash, joint inflamation, abdominal pain or renal disease. The specific rash is necesary for the confirmation of the diagnosis. Henoch-Schönlein purpura can rarely present with a complication withot a prior presentation of the rash. In these cases diagnosis is difficult until the presentation of the specific skin manifestation. In the majority of patients the disease course is not complicated and has a good prognosis.Conclusion: In this article we present three patients with an atypical presentation of the disease and a review of current literature on the topic.

Steroid Effects on the Course of Abdominal Pain in Children With Henoch-Schonlein Purpura

PEDIATRICS ◽  
1987 ◽  
Vol 79 (6) ◽  
pp. 1018-1021
Author(s):  
NORMAN D. ROSENBLUM ◽  
HARLAND S. WINTER
Keyword(s):  
Abdominal Pain ◽  
Gastrointestinal Symptom ◽  
Systemic Vasculitis ◽  
Skin Lesions ◽  
Intestinal Bleeding ◽  
Controlled Trials ◽  
Henoch Schonlein Purpura ◽  
Intestinal Lesions ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Henoch-Schonlein purpura is a systemic vasculitis of unknown cause that is characterized primarily by abdominal pain, arthritis, and purpuric skin lesions. Abdominal pain is the most common gastrointestinal symptom, but intestinal bleeding and intussusception may occur. Previous studies have supported the use of steroids in managing the abdominal pain of Henoch-Schonlein purpura.1,2 Because there are no controlled trials using steroids in this disease, their value in affecting the intestinal lesions of Henoch-Schonlein purpura remains unknown. The purpose of this retrospective study was to assess the effect of corticosteroids on the outcome of abdominal pain in children with Henoch-Schonlein purpura. PATIENTS AND METHODS

scholarly journals Intravenous γ Globulin for Intractable Abdominal Pain due to IgA Vasculitis

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
George Naifa ◽  
George Totikidis ◽  
Sonia Alexiadou ◽  
Christina Kolona ◽  
Elpis Mantadakis
Keyword(s):  
Abdominal Pain ◽  
Iga Vasculitis ◽  
Controlled Clinical Trials ◽  
Corticosteroid Administration ◽  
Randomized Controlled Clinical Trials ◽  
Randomized Controlled ◽  
Term Administration ◽  
Schonlein Purpura ◽  
Safe Treatment Option

IgA vasculitis (formerly known as Henoch–Schönlein purpura or anaphylactoid purpura) is a usually benign vasculitis that affects children of school age. The disease is characterized by the tetrad of palpable purpura, arthralgia/arthritis, abdominal pain, and hematuria. Treatment of IgA vasculitis is mainly supportive, with administration of simple analgesics. Corticosteroids have been shown to reduce and/or ameliorate the occurrence of abdominal pain which may be severe. We present two children with IgA vasculitis and severe abdominal pain despite corticosteroid administration, who responded promptly to intravenous γ globulin (IVIg) with complete resolution of their symptoms and review of the relevant medical literature. Given the toxicity and/or need for long-term administration of other second-line immunosuppressive therapies in corticosteroid-resistant IgA vasculitis, such as rituximab, cyclosporine, cyclophosphamide, azathioprine, or colchicine, we propose that IVIg may be a useful and safe treatment option, although randomized controlled clinical trials are needed in order to clarify its role in the treatment of abdominal pain in IgA vasculitis.

scholarly journals Intestinal Infarction and Portal Vein Thrombosis in a Patient with Henoch Schonlein Purpura

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Mekdess Abebe ◽  
Asha Patnaik ◽  
Frederick Miller ◽  
Heidi Roppelt ◽  
Nand K. Wadhwa ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Therapeutic Intervention ◽  
Systemic Vasculitis ◽  
Henoch Schonlein Purpura ◽  
Vein Thrombosis ◽  
Schonlein Purpura ◽  
Benign Course ◽  
Henoch Schönlein Purpura

Henoch Schonlein purpura is a systemic vasculitis that commonly affects children and teenagers but also affects adults of all ages. In most instances it has a benign course. Organ involvement, particularly in adults, and notably the kidneys and gastrointestinal tract may require therapeutic intervention and may have a less favorable outcome. We report a case of a 58-year-old man who presented with purpura and who rapidly developed catastrophic intestinal vasculitis, leading to his demise.

scholarly journals Acute appendicitis as the first manifestation of HenochSchönlein purpura

2020 ◽  
Vol 0 ◽  
pp. 1-3
Author(s):  
Pedro Nogarotto Cembraneli ◽  
Julia Brasileiro de Faria Cavalcante ◽  
Renata Brasileiro de Faria Cavalcante ◽  
José Edison da Silva Cavalcante
Keyword(s):  
Abdominal Pain ◽  
Acute Appendicitis ◽  
Acute Abdomen ◽  
Joint Pain ◽  
Systemic Vasculitis ◽  
Symptom Control ◽  
Small Vessel ◽  
Palpable Purpura ◽  
Gangrenous Appendicitis ◽  
Schonlein Purpura

Henoch-Schönlein purpura (HSP) is a small vessel systemic vasculitis. Typical symptoms include palpable purpura, joint pain, and abdominal pain. Most cases improve after a few weeks, not requiring any treatments other than symptom control. Acute abdomen resulting from vasculitis is very rare and should be treated as a surgical emergency. We report the case of a 9-year-old boy with acute gangrenous appendicitis as the first manifestation of HSP.

scholarly journals The characteristics of video capsule endoscopy in pediatric Henoch–Schönlein purpura with gastrointestinal symptoms

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Youhong Fang ◽  
Kerong Peng ◽  
Hong Zhao ◽  
Jie Chen
Keyword(s):  
Gastrointestinal Tract ◽  
Capsule Endoscopy ◽  
Gastrointestinal Symptoms ◽  
Video Capsule Endoscopy ◽  
Small Vessel Vasculitis ◽  
Henoch Schonlein Purpura ◽  
Laboratory Findings ◽  
Abdominal Symptoms ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Abstract Background Henoch–Schönlein purpura (HSP) is a systemic small-vessel vasculitis also named IgA vasculitis that commonly affects the gastrointestinal tract. The video capsule endoscopy (VCE) characteristics of pediatric HSP patients are rarely reported. Methods Patients diagnosed with HSP and analyzed by VCE examination at our hospital from February 2010 to January 2019 are enrolled. The clinical features, laboratory findings, and the characteristics of VCE findings are studied. Results There are 30 patients enrolled in this investigation from February 2010 to January 2020. The mean age of these patients is 96.9 ± 35.8 months, and the most frequent finding of VCE is mucosal erosion, which account for 79.3% of the patients, and followed by mucosal erythema or petechia accounted for 69% of the patients. Regarding the disease location detected by endoscopy, jejunum is the most common involved part of the gastrointestinal tract in pediatric HSP patients. All the patients had the jejunum involved except in one patient the VCE did not pass through the pylorus. One third of the patients involved the descending portion of duodenum. No side effect is observed in this study. Conclusions VCE may be an excellent adjust tool for evaluation of the gastrointestinal tract in children with abdominal symptoms without typical purpura in suspected pediatric HSP patients. VCE appears to be superior to esophagogastroduodenoscopy in detecting small intestinal lesions of HSP and has an excellent safety profile.

scholarly journals The Association between Absence of Abdominal Pain and Mortality in Lower Intestinal Perforation in Patients with Autoimmune Rheumatic Diseases

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Yukari Endo ◽  
Yoshiyuki Abe ◽  
Shingo Kawano ◽  
Taiki Ando ◽  
Kazuhiro Sakamoto ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Abdominal Pain ◽  
Kidney Disease ◽  
Rheumatic Diseases ◽  
Intestinal Perforation ◽  
Kidney Diseases ◽  
Systemic Vasculitis ◽  
Poor Prognostic Factor ◽  
Autoimmune Rheumatic Diseases ◽  
Abdominal Symptoms

Objective. To determine mortality and predictive factors for lower intestinal perforation (LIP) among patients with autoimmune rheumatic diseases.Methods. This retrospective, single-center, observational study analyzed mortality rates in 31 autoimmune rheumatic disease patients with LIP who were admitted to our hospital from January 2002 to June 2017. The primary outcome was the mortality rate during hospitalization.Results. The median age at the time of LIP was 61 years, and the survival rate at discharge was 64.5%. Eleven patients died of sepsis during hospitalization. Cox univariable analysis for mortality during hospitalization showed that absence of abdominal pain (hazard ratio (HR) 5.61, 95% confidence interval (CI) 1.38–22.9), higher age (HR 1.06, 95% CI 1.01–1.11), chronic kidney disease (HR 6.89, 95% CI 1.85–25.7), systemic vasculitis (HR 3.95, 95% CI 1.14–13.6), higher blood urea nitrogen (HR 1.02, 95% CI 1.01–1.04), higher serum creatinine (HR 1.41, 95% CI 1.06–1.87), and LIP due to malignancy (HR 14.3, 95% CI 1.95–105.1) significantly increased mortality.Conclusion. Abdominal pain was absent in 16% of LIP patients with autoimmune rheumatic diseases, and this absence was a poor prognostic factor in this cohort. Moreover, higher age, chronic kidney disease, systemic vasculitis, and LIP due to malignancy were associated with significantly increased mortality. Physicians should be aware of LIP in autoimmune disease patients with higher age, chronic kidney diseases, or systemic vasculitis even if patients reveal mild abdominal symptoms.

scholarly journals Gastrointestinal Involvement in Henoch Schonlein Purpura : A Case Report

2020 ◽  
Vol 8 (2) ◽  
Author(s):  
Siti Kamariah CM ◽  
Rohaizan Y
Keyword(s):  
Case Report ◽  
Bowel Wall ◽  
Systemic Vasculitis ◽  
Bowel Ischemia ◽  
Gastrointestinal Involvement ◽  
Henoch Schonlein Purpura ◽  
Small Vessels ◽  
Abdominal Symptoms ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Henoch-Schonlein purpura or anaphylactoid purpura is a systemic vasculitis of unknown cause that affects small vessels and mainly involves the skin, joints, gastrointestinal tract and kidneys. Gastrointestinal involvement occurs in more than half of patients and is thought to be related to edema and intramural haemorrhage. Radiologically the gastrointestinal findings are mainly those of bowel ischemia with “thumbprinting” and bowel wall oedema. Although this disease is usually treated conservatively, aggressive intervention is occasionally performed because of acute abdominal symptoms due to complications, such as perforation, intussusception and obstruction. This report illustrates a case of Henoch-Schonlein purpura with acute abdominal symptoms due to intussusception.

scholarly journals Effect of early enteral feeding on recovery profile in mild acute pancreatitis

2020 ◽  
Vol 7 (6) ◽  
pp. 1969
Author(s):  
Kailash Chandran ◽  
Sam Christy Mammen
Keyword(s):  
Acute Pancreatitis ◽  
Abdominal Pain ◽  
Hospital Stay ◽  
Enteral Feeding ◽  
The Body ◽  
Advantages And Disadvantages ◽  
Duration Of Hospital Stay ◽  
Early Enteral Feeding ◽  
Abdominal Symptoms ◽  
Mild Acute Pancreatitis

Background: Acute pancreatitis is a pestilent disease with severity ranging from mild and self-limiting to a rapidly progressive illness leading to multi organ failure. Mild acute pancreatitis is inflammation of the pancreas with minimal remote organ involvement. Since the disturbance in the homeostasis is minimal, the treatment aims at supporting the native reparative processes of the body. One of the main supportive mechanisms is adequate nutritional supplementation. Gut barrier damage in the early phase of acute pancreatitis accounts for the bacterial translocation, initiation of sepsis, infected pancreatic necrosis and SIRS. Aim of the study was to determine the feasibility, advantages and disadvantages of early enteral nutrition in mild acute pancreatitis.Methods: 40 patients taken consecutively from units which start enteral feeds before 48 hours (study group) were compared against 40 patients taken consecutively from units where patients will be kept fasting for 48 hours (control group) to determine whether early enteral feeding is better in determining the recovery in terms of duration of hospital stay, reduction in abdominal symptoms and use of analgesics.Results: There was significant reduction in the duration of hospital stay (p=0.011), intensity and duration of abdominal pain, need for analgesics, and risk of oral food intolerance in the study group.Conclusions: Patients with mild acute pancreatitis can safely be started on early enteral feeds. It reduces gastro intestinal adverse effects, abdominal pain and need for analgesics and improves oral food tolerance causing shorter hospital stay. 

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