scholarly journals Intestinal Infarction and Portal Vein Thrombosis in a Patient with Henoch Schonlein Purpura

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Mekdess Abebe ◽  
Asha Patnaik ◽  
Frederick Miller ◽  
Heidi Roppelt ◽  
Nand K. Wadhwa ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Therapeutic Intervention ◽  
Systemic Vasculitis ◽  
Henoch Schonlein Purpura ◽  
Vein Thrombosis ◽  
Schonlein Purpura ◽  
Benign Course ◽  
Henoch Schönlein Purpura

Henoch Schonlein purpura is a systemic vasculitis that commonly affects children and teenagers but also affects adults of all ages. In most instances it has a benign course. Organ involvement, particularly in adults, and notably the kidneys and gastrointestinal tract may require therapeutic intervention and may have a less favorable outcome. We report a case of a 58-year-old man who presented with purpura and who rapidly developed catastrophic intestinal vasculitis, leading to his demise.

scholarly journals Successful Treatment of Hemorrhagic Bullous Henoch-Schönlein Purpura with Oral Corticosteroid: A Case Report

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Celebi Kocaoglu ◽  
Ramazan Ozturk ◽  
Yasar Unlu ◽  
Fatma Tuncez Akyurek ◽  
Sukru Arslan
Keyword(s):  
Case Report ◽  
Gastrointestinal Tract ◽  
Female Patient ◽  
Oral Corticosteroid ◽  
Systemic Vasculitis ◽  
Immunoglobulin A ◽  
Henoch Schonlein Purpura ◽  
Hemorrhagic Bullae ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Henoch-Schönlein purpura (HSP) is a vasculitis of small-sized blood vessels, resulting from immunoglobulin-A-mediated inflammation. It is the most common acute systemic vasculitis in childhood and mainly affects skin, gastrointestinal tract, joints, and kidneys. The characteristic rash of HSP consists of palpable purpuric lesions 2 to 10 mm in diameter concentrating in the buttocks and lower extremities. The occurrence of hemorrhagic bullae in children with HSP is rarely encountered. This report describes a 4.5-year-old female patient with HSP associated with hemorrhagic bullous lesions.

Steroid Effects on the Course of Abdominal Pain in Children With Henoch-Schonlein Purpura

PEDIATRICS ◽  
1987 ◽  
Vol 79 (6) ◽  
pp. 1018-1021
Author(s):  
NORMAN D. ROSENBLUM ◽  
HARLAND S. WINTER
Keyword(s):  
Abdominal Pain ◽  
Gastrointestinal Symptom ◽  
Systemic Vasculitis ◽  
Skin Lesions ◽  
Intestinal Bleeding ◽  
Controlled Trials ◽  
Henoch Schonlein Purpura ◽  
Intestinal Lesions ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Henoch-Schonlein purpura is a systemic vasculitis of unknown cause that is characterized primarily by abdominal pain, arthritis, and purpuric skin lesions. Abdominal pain is the most common gastrointestinal symptom, but intestinal bleeding and intussusception may occur. Previous studies have supported the use of steroids in managing the abdominal pain of Henoch-Schonlein purpura.1,2 Because there are no controlled trials using steroids in this disease, their value in affecting the intestinal lesions of Henoch-Schonlein purpura remains unknown. The purpose of this retrospective study was to assess the effect of corticosteroids on the outcome of abdominal pain in children with Henoch-Schonlein purpura. PATIENTS AND METHODS

scholarly journals Decreased glycolysis induced dysfunction of NK cells in Henoch-Schonlein purpura patients

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Wenjia Chai ◽  
Xiaolin Wang ◽  
Wei Wang ◽  
Hui Wang ◽  
Wenjun Mou ◽  
...  
Keyword(s):  
Nk Cells ◽  
Systemic Vasculitis ◽  
Metabolic Reprogramming ◽  
Healthy Children ◽  
Henoch Schonlein Purpura ◽  
Reduced Frequency ◽  
Activating Receptors ◽  
Innate Lymphocytes ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Abstract Background Henoch-Schonlein purpura (HSP) is the most common systemic vasculitis of the childhood. However, its mechanisms and pathogenesis still need more exploration. Natural killer (NK) cells are innate lymphocytes, and there is a growing appreciation that cellular metabolism is important in determining the immune responsiveness of lymphocytes. Thus, we aimed to analyze the NK cells phenotype and explore the association between glucose metabolism and NK cells function in HSP patients. Results A total number of 64 HSP patients and 34 healthy children were included. The HSP patients were divided into two groups according to whether accompanied with nephritis or not. NK cells in HSP patients without nephritis showed a reduced frequency in peripheral blood, a down-regulated expression of activating receptors both NKp30 and NKp46, and an attenuated cytotoxic function against tumor cells. In addition, the function impairment of NK cells was shown to exacerbate in HSPN. Our data further revealed an aberrant metabolic reprogramming of NK cells in HSP patients. Upon stimulation with cytokines (IL-15, IL-12 and IL-2), NK cells from healthy controls switched to an elevated glycolysis rate to support their effector function. By contrast, the glycolysis rate of activated NK cells in HSP group was not significantly up-regulated from the resting level possibly owing to the inhibition of mTORC1. Conclusions Our study found that HSP patients were accompanied with dysfunction of NK cells. We concluded that the dysfunction of NK cells in HSP patients was induced with a decreased glycolysis rate and suggested that metabolic reprogramming of NK cells might be a player in the pathogenesis of HSP.

scholarly journals The Characteristics of Video Capsule Endoscopy in Pediatric Henoch–Schönlein Purpura with Gastrointestinal Symptoms

2020 ◽  
Author(s):  
Youhong Fang ◽  
Kerong Peng ◽  
Hong Zhao ◽  
Jie Chen
Keyword(s):  
Gastrointestinal Tract ◽  
Capsule Endoscopy ◽  
Gastrointestinal Symptoms ◽  
Video Capsule Endoscopy ◽  
Small Vessel Vasculitis ◽  
Henoch Schonlein Purpura ◽  
Laboratory Findings ◽  
Pass Through ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Abstract Background Henoch–Schönlein purpura (HSP) is a systemic small-vessel vasculitis that commonly affects gastrointestinal tract. The video capsule endoscopy (VCE) characteristics of pediatric HSP patients were rarely investigated. Methods Patients diagnosed with HSP by VCE examination at our hospital from February 2010 to January 2019 are analyzed. The clinical features, laboratory findings, and the characteristics of VCE findings are studied. Results There are 30 patients enrolled in this investigation from February 2010 to January 2020. The mean age of these patients is 96.9±35.8 months, and the most frequent finding of VCE is mucosal erosion, which account for 69 % of the patients, and followed by mucosal erythema or petechia accounted for 79.3 % of the patients. Regarding to the disease location detected by endoscopy, jejunum is the most common involved part of the gastrointestinal tract in pediatric HSP patients. All the patients had jejunum involved except in one patient the VCE did not pass through the pylorus. One third of the patients involved the descent part of duodenum. No side effects are observed in this study. Conclusions VCE is safe and effective in the diagnosis of gastrointestinal involved HSP patients with or without typical skin purpura. Jejunum is the most common involve location in gastrointestinal.

scholarly journals Not Just A Rash!

2010 ◽  
Vol 9 (1) ◽  
pp. 27-29
Author(s):  
MA Fox ◽  
◽  
JA Fox ◽  
Al-Shamma S ◽  
Leiper K ◽  
...  
Keyword(s):  
Hidradenitis Suppurativa ◽  
Systemic Vasculitis ◽  
Gastrointestinal Haemorrhage ◽  
Henoch Schonlein Purpura ◽  
Classic Case ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Henoch-Schonlein Purpura (HSP) is the most common systemic vasculitis in childhood and can present in adults. It is a self-limiting disease characterised by a tetrad of manifestations including the mandated typical cutaneous hallmark. We present a classic case of HSP complicated by gastrointestinal haemorrhage associated with hidradenitis suppurativa.

scholarly journals Henoch-Schönlein purpura

2016 ◽  
Vol 1 (3) ◽  
Author(s):  
Natalia Zdanowska ◽  
Agnieszka Owczarczyk-Saczonek ◽  
Waldemar Placek
Keyword(s):  
Surgical Intervention ◽  
Systemic Vasculitis ◽  
Bowel Perforation ◽  
Careful Monitoring ◽  
Henoch Schonlein Purpura ◽  
Life Threatening ◽  
Adults And Children ◽  
The Central Nervous System ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

<p>Henoch-Schönlein purpura (HSP) is an acute, systemic vasculitis which usually occurs in young adults and children. The skin involvement may lead to the manifestation of symptoms associated with vasculitis in intestines, kidneys, and the central nervous system. The incidence of bowel perforation in course of HSP is very seldom and it occurs about 10 days after the appearance of the first symptoms. We present a 23-year-old male patient with jejunal intussusception in the course of HSP. The patient was operated urgently with resection of part of the small intestine. Adults rarely suffer from the occurrence of abdominal pain and fever, but sometimes they require careful monitoring and surgical intervention because misdiagnosis can be life threatening.</p><p class="Standard"> </p>

scholarly journals Tubulointerstitial Infiltration of M2 Macrophages in Henoch-Schönlein Purpura Nephritis Indicates the Presence of Glomerular Crescents and Bad Clinical Parameters

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Jisup Kim ◽  
Sung-Eun Choi ◽  
Keum Hwa Lee ◽  
Hyeon Joo Jeong ◽  
Jae Il Shin ◽  
...  
Keyword(s):  
Systemic Vasculitis ◽  
Renal Involvement ◽  
International Study ◽  
Clinical Parameters ◽  
M2 Macrophages ◽  
Henoch Schonlein Purpura ◽  
Severe Manifestation ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura ◽  
Purpura Nephritis

Henoch-Schönlein purpura (HSP) is the most common systemic vasculitis in children, and renal involvement (HSP nephritis, HSPN) is a severe manifestation. HSPN is histologically classified by the International Study of Kidney Disease in Children (ISKDC) based on mesangial hypercellularity and the extent of glomerular crescents. Macrophages, categorized as M1 or M2, frequently infiltrate in various glomerular and tubulointerstitial diseases and infiltration of specific subtypes is associated with disease progression. Therefore, to identify whether infiltration of M1 or M2 macrophages has clinical significance, we quantified the subtypes of macrophages in 49 HSPN specimens and correlated the counts with histologic features and clinical parameters. Higher tubulointerstitial M2 counts were associated with chronic renal failure (CRF), ISKDC classes III-IV, and crescents (P<0.001, 0.002, 0.001). Glomerular M2 counts were significantly related to ISKDC classes III-IV and crescents (area under curve, AUC 0.804, 0.833). Tubulointerstitial M2 counts were associated with CRF, ISKDC classes III-IV, and crescents (AUC 0.872, 0.778, 0.830). Tubulointerstitial M2 counts also revealed higher AUC than tubulointerstitial M1 counts for CRF (P=0.036) and ISKDC classes III-IV (P=0.047). Glomerular M2 counts revealed higher AUC than glomerular M1 counts for ISKDC classes III–IV (P=0.024). Tubulointerstitial M2 counts were the most powerful parameter for CRF (AUC 0.872) and revealed even higher AUC than ISKDC classification (AUC 0.716) with borderline significance (P=0.086) for CRF. In summary, tubulointerstitial M2 counts were a superior parameter to tubulointerstitial M1 counts and even to ISKDC classification indicating the presence of CRF.

scholarly journals Endoscopic and microscopic findings of gastrointestinal tract in Henoch–Schönlein purpura

Medicine ◽  
2019 ◽  
Vol 98 (20) ◽  
pp. e15643 ◽  
Author(s):  
Yeeun Han ◽  
So-Young Jin ◽  
Dong Won Kim ◽  
Yoon Mi Jeen ◽  
Yon Hee Kim ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Henoch Schonlein Purpura ◽  
Schonlein Purpura ◽  
Microscopic Findings ◽  
Henoch Schönlein Purpura

scholarly journals Successful Outcome of a Corticodependent Henoch-Schönlein Purpura Adult with Rituximab

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Taylor Pindi Sala ◽  
Jean-Marie Michot ◽  
Renaud Snanoudj ◽  
Marion Dollat ◽  
Emmanuel Estève ◽  
...  
Keyword(s):  
Systemic Vasculitis ◽  
Transplant Rejection ◽  
Immunoglobulin A ◽  
Corticosteroid Treatment ◽  
Successful Outcome ◽  
Henoch Schonlein Purpura ◽  
Small Vessels ◽  
History Of ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Henoch-Schönlein purpura (HSP) is a systemic vasculitis involving small vessels with deposition of immunoglobulin A (IgA) complexes, usually affecting children. Compared with children, HSP in adults is more severe and frequently associated with cancer. We report the case of a 49-year-old woman with medical history of kidney transplantation for segmental glomerular hyalinosis. Eight years after the transplantation, while taking combined immunosuppressive therapy with tacrolimus and azathioprine indicated for the prevention against transplant rejection, she developed a Henoch-Schönlein purpura. Vasculitis involves skin and sciatic peroneal nerve and she received systemic corticosteroid treatment. Because of four relapses and corticosteroid dependence, the patient was treated with rituximab (two intravenous infusions of 1000 mg given two weeks apart). Successful outcome was observed along two years of follow-up. This new case of successful use of rituximab in HSP promotes more investigations of this treatment in clinical trials.

scholarly journals The characteristics of video capsule endoscopy in pediatric Henoch–Schönlein purpura with gastrointestinal symptoms

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Youhong Fang ◽  
Kerong Peng ◽  
Hong Zhao ◽  
Jie Chen
Keyword(s):  
Gastrointestinal Tract ◽  
Capsule Endoscopy ◽  
Gastrointestinal Symptoms ◽  
Video Capsule Endoscopy ◽  
Small Vessel Vasculitis ◽  
Henoch Schonlein Purpura ◽  
Laboratory Findings ◽  
Abdominal Symptoms ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Abstract Background Henoch–Schönlein purpura (HSP) is a systemic small-vessel vasculitis also named IgA vasculitis that commonly affects the gastrointestinal tract. The video capsule endoscopy (VCE) characteristics of pediatric HSP patients are rarely reported. Methods Patients diagnosed with HSP and analyzed by VCE examination at our hospital from February 2010 to January 2019 are enrolled. The clinical features, laboratory findings, and the characteristics of VCE findings are studied. Results There are 30 patients enrolled in this investigation from February 2010 to January 2020. The mean age of these patients is 96.9 ± 35.8 months, and the most frequent finding of VCE is mucosal erosion, which account for 79.3% of the patients, and followed by mucosal erythema or petechia accounted for 69% of the patients. Regarding the disease location detected by endoscopy, jejunum is the most common involved part of the gastrointestinal tract in pediatric HSP patients. All the patients had the jejunum involved except in one patient the VCE did not pass through the pylorus. One third of the patients involved the descending portion of duodenum. No side effect is observed in this study. Conclusions VCE may be an excellent adjust tool for evaluation of the gastrointestinal tract in children with abdominal symptoms without typical purpura in suspected pediatric HSP patients. VCE appears to be superior to esophagogastroduodenoscopy in detecting small intestinal lesions of HSP and has an excellent safety profile.

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