scholarly journals Combination therapy with azathioprine, cyclosporine and ketoconazole in a dog with concurrent pemphigus foliaceus and hyperadrenocorticism – Case report

2020 ◽  
Author(s):  
Taesik Yun ◽  
Yoonhoi Koo ◽  
Sanggu Kim ◽  
Hakhyun Kim ◽  
Soochong Kim ◽  
...  
Keyword(s):  
Case Report ◽  
Combination Therapy ◽  
Clinical Signs ◽  
Poor Response ◽  
Pemphigus Foliaceus ◽  
Once Daily ◽  
First Case ◽  
History Of ◽  
Erythematous Plaques

AbstractA 10-year-old, spayed female Shih Tzu dog presented with a history of progressive erythema and multiple crusts developing 85 days previously. The dog had been diagnosed with hyperadrenocorticism (HAC) 55 days prior to presentation and was treated with oral trilostane (2.86 mg/kg, once daily) that was discontinued due to a poor response. In addition to generalised alopecia, erythematous plaques and crusts were noted on the trunk, head and footpads. Lesional impression smears revealed numerous acantholytic cells and non-degenerated neutrophils. Histopathological findings demonstrated subcorneal pustules with acantholytic cells and intact neutrophils. On the basis of these findings, we diagnosed pemphigus foliaceus (PF) with concurrent HAC. We wished to avoid glucocorticoids and, therefore, prescribed oral, once-daily azathioprine (2 mg/kg), modified cyclosporine (7 mg/kg) and ketoconazole (5 mg/kg). By day 71 post-treatment, the erythematous crusts had almost disappeared and the alopecia had improved considerably. However, by the subsequent follow-up examination on day 99, the clinical signs had reappeared due to the tapering of cyclosporine. To the best of our knowledge, this is the first case report describing concurrent PF and HAC in a dog. Combination therapy with azathioprine, modified cyclosporine and ketoconazole was effective, and should be considered for dogs diagnosed with concurrent autoimmune diseases and HAC.

scholarly journals Effect of doxycycline on stifle lameness: a preliminary clinical observation in twelve dogs

2011 ◽  
Vol 1 (1) ◽  
pp. 7
Author(s):  
Kei Hayashi ◽  
Joseph D. Frank ◽  
Paul A. Manley ◽  
Peter Muir
Keyword(s):  
Clinical Signs ◽  
Poor Response ◽  
Positive Outcome ◽  
Presumptive Diagnosis ◽  
Once Daily ◽  
Doxycycline Treatment ◽  
History Of ◽  
Group A ◽  
Group B

The clinical efficacy of oral doxycycline was evaluated in twelve dogs with stifle arthritis and a presumptive diagnosis of early cruciate disease. Doxycycline (2.5-4.5 mg/kg once daily) was administered orally for 3 to 8 weeks. Eight dogs, who presented prior to the treatment with clinical signs of 4 weeks or fewer duration (group B), had a good response to doxycycline, whereas four dogs with a longer history of lameness (group A) had a poor response. The follow-up periods ranged from 2 to 12 months after discontinuation of the doxycycline treatment (median=6.5 months, 3 months in group A, and 9.5 months in group B). There was a significant correlation between the duration of lameness and the subjective grading of clinical improvement. In 68% of these cases of dogs with stifle arthritis (8/12), the oral administration of doxycycline resulted in the improvement of lameness, even after discontinuation of doxycycline. Careful selection of patients based on the duration of their lameness appears to be crucial in order to achieve a positive outcome.

scholarly journals  Erythema multiforme minor in a dog following inappropriate intranasal Bordetella bronchiseptica vaccination: a case report

2011 ◽  
Vol 56 (No. 11) ◽  
pp. 568-572 ◽  
Author(s):  
MH Kang ◽  
HM Park
Keyword(s):  
Case Report ◽  
Erythema Multiforme ◽  
Clinical Signs ◽  
Skin Lesions ◽  
Bordetella Bronchiseptica ◽  
Hydropic Degeneration ◽  
First Case ◽  
History Of ◽  
One Year

A one-year-old, intact female, Yorkshire terrier dog was presented with a six-month history of multifocal, polycyclic erythematous lesions with epidermal collarette formation at the axillae, the trunk and ventral abdomen. The dog had a history of an inappropriate vaccine administration one day prior to the onset of clinical signs. The histopathology of the lesions revealed apoptosis of keratinocytes in the overlying epidermis, hydropic degeneration and lymphocytic exocytosis. The clinical signs and histopathology of the lesions were compatible with erythema multiforme. The skin lesions resolved after treatment with prednisolone combined with azathioprine for one month. No recurrence of clinical signs occurred during the follow-up period (four months). This is the first case report of erythema multiforme associated with an accidental subcutaneous injection of a Bordetella bronchiseptica vaccine.  

scholarly journals Diagnostic Workup and Treatment of a Rare Apocrine Hidrocystoma Affecting the Oral Mucosa: A Clinical and Histological Case Report

2017 ◽  
Vol 2017 ◽  
pp. 1-5
Author(s):  
Pier Paolo Poli ◽  
Luca Creminelli ◽  
Valeria Moramarco ◽  
Alessandro Del Gobbo ◽  
Franco Ferrante ◽  
...  
Keyword(s):  
Case Report ◽  
Oral Mucosa ◽  
Clinical Signs ◽  
Sweat Glands ◽  
Histopathological Analysis ◽  
Cystic Tumors ◽  
Left Posterior ◽  
History Of ◽  
Submucosal Mass

Apocrine hidrocystomas are rare benign cystic tumors originating from the secretory portion of apocrine sweat glands. To the best of our knowledge, there is no evidence currently available reporting the presence of apocrine hidrocystomas in the oral cavity. Therefore, this case report aims to describe the clinical and histological features of an apocrine hidrocystoma affecting the oral mucosa. A 69-year-old male patient presented with a 1-year history of a solitary, well-circumscribed, submucosal mass in the left posterior buccal mucosa. The clinical examination revealed a yellowish soft, fluctuant, and painless lesion with no clinical signs of erythema or ulcerations of the overlying epithelium. The entire lesion was excised and histopathological analysis confirmed the diagnosis of apocrine hidrocystoma. No recurrence was observed after a 1-year follow-up.

scholarly journals Posaconazole in the treatment of refractory Purpureocillium lilacinum (former Paecilomyces lilacinus) keratitis: the salvation when nothing works

2019 ◽  
Vol 12 (4) ◽  
pp. e228645 ◽  
Author(s):  
Mariana Almeida Oliveira ◽  
Analia Carmo ◽  
Andreia Rosa ◽  
Joaquim Murta
Keyword(s):  
Case Report ◽  
Clinical Condition ◽  
Penetrating Keratoplasty ◽  
Contact Lenses ◽  
Clinical Signs ◽  
Paecilomyces Lilacinus ◽  
Purpureocillium Lilacinum ◽  
History Of ◽  
History Of Pain

We report a case of a 41-year-old woman, wearer of contact lenses who was presented to the emergency room with a 2-month history of pain and red eye. She presented with a severe keratitis refractory to quinolones, fortified antibiotics and clotrimazole. Due to the risk of perforation, a tectonic penetrating keratoplasty (PK) was performed. Clinical signs of keratitis recurrence were observed and cultures were positive for Purpureocillium lilacinum (former Paecilomyces lilacinus). The patient did not improve on topical amphotericin B and intracameral voriconazole. Worsening of clinical condition required a new PK. Oral posaconazole was initiated postoperatively and suspended at the fourth postoperative month. The cornea remains clear until the last follow-up visit, 12 months after the second graft. To our knowledge, this is the second case report that documents the effectiveness of oral posaconazole in a refractory P. lilacinus keratitis, resistant to other second-generation triazoles and conventional antifungals.

scholarly journals Hydatid bone disease of the humerus: A case report from East Africa

2021 ◽  
Vol 2 (4) ◽  
Author(s):  
Antonio Loro ◽  
◽  
Francesca Loro ◽  
Niall Brown ◽  
◽  
...  
Keyword(s):  
Case Report ◽  
Bone Disease ◽  
Appendicular Skeleton ◽  
First Case ◽  
Healing Fracture ◽  
Health Centres ◽  
Diagnostic Difficulties ◽  
History Of ◽  
The Right

Skeletal hydatidosis is extremely rare and involvement of the long bones of the appendicular skeleton is exceptional. We report on a case of a 68-year-old Ugandan woman who presented with a long standing history of a non-healing fracture of the mid-diaphysis of the right humerus. She had undergone multiple surgeries in peripheral health centres during the previous years. A shoulder disarticulation was carried out in our facility in agreement with the patient, who refused any other attempt of bone reconstruction. A diagnosis of hydatid bone disease was confirmed intra-operatively. There is no recurrence of the disease for a two-year follow-up period. To our knowledge this is the first case report of skeletal hydatosis in Uganda. It emphasises the diagnostic difficulties and delays, and how this led to inadequate management for the patient in this case.

scholarly journals Idiopathic seasonal alopecia in horse: case report

2020 ◽  
Vol 72 (2) ◽  
pp. 431-436
Author(s):  
A.F. Souza ◽  
J. Schade ◽  
M.S. Casa ◽  
S.D. Traverso ◽  
J.H. Fonteque
Keyword(s):  
Case Report ◽  
Hair Growth ◽  
Inflammatory Infiltrate ◽  
Clinical Signs ◽  
Hair Shaft ◽  
Hair Follicles ◽  
Histological Evaluation ◽  
Unknown Etiology ◽  
First Case

ABSTRACT This report describes the first case of idiopathic seasonal alopecia in a horse in Brazil. The disease is of unknown etiology, characterized by alopecic processes in the thoracic and lateral abdominal regions, in a bilaterally symmetrical way. An eight-year-old male grade horse was treated presenting hair loss in a bilaterally symmetrical manner in the arm and abdomen areas, without any other associated clinical signs. The areas with alopecia showed no pruritus, inflammation or scaling. On the epidermis, the histological evaluation presented irregular hyperplasia, hyperpigmentation, compact orthokeratosis, edema and an inflammatory infiltrate. The hair follicles were active and containing hair shaft. The case was monitored with photographic records for two consecutive years (2012 to 2014), in which the hair fall occurred at the end of autumn with spontaneous hair growth in the middle of the summer. The diagnosis was based on the history, histopathology and photographic follow-up performed. Although mentioned in the literature, this is the first clinical and pathological description of such disorder affecting an equine in Brazil.

scholarly journals A95 DO BENIGN LIVER TUMOURS ALWAYS STAY BENIGN? A CASE REPORT OF HEPATIC INFLAMMATORY PSEUDOTUMOR AND SUBSEQUENT CHOLANGIOCARCINOMA

2020 ◽  
Vol 3 (Supplement_1) ◽  
pp. 110-111
Author(s):  
K Onizuka ◽  
M Schell ◽  
K Tsoi
Keyword(s):  
Case Report ◽  
De Novo ◽  
Fatty Infiltration ◽  
Fibrous Tissue ◽  
Inflammatory Cell Infiltrate ◽  
Benign Lesions ◽  
First Case ◽  
Spindle Cell Proliferation ◽  
History Of

Abstract Background Hepatic inflammatory pseudotumors (HIPTs) are rare, benign lesions of unclear etiology which can be challenging to diagnose and differentiate from malignant processes. The optimal treatment and follow up of these lesions is controversial, and literature exists to support both surgical resection as well as conservative medical management. The natural history of HIPTs is generally benign, however there are some reports of disease recurrence, and two reports of malignant transformation to lymphoma. Aims To describe a case of HIPT with progression to malignancy. Methods Case report and review of the literature. Results A 53-year-old male presented to St. Joseph’s Healthcare Hamilton in August 2019 with a three-week history of abdominal pain and distention. He had a previous diagnosis of HIPT, incidentally found on ultrasound four years earlier. CT in January 2016 reported two well-marginated focal liver masses with peripheral rim enhancement and central hypodensity, 3.9 x 3.9cm in segment 2, and a 6 x 4.6cm central lesion, as well as diffuse fatty infiltration of the liver. Bloodwork showed a mildly elevated Ca19-9 626 kU/L, and normal CEA and AFP. Two biopsies were performed in 2016, both demonstrating dense fibrous tissue and abundant chronic inflammatory cell infiltrate composed of lymphocytes, histiocytes, eosinophils, and plasma cells, with some areas of bland spindle cell proliferation. No malignant cells, and histology was felt to be consistent with HIPT. MRI in September 2017 showed progression of disease, prompting Rheumatology to initiate immunosuppressive medications, however serial imaging continued to show increase in the size and number of lesions. Upon presentation to hospital in August 2019 ultrasound showed new ascites, with ascitic fluid analysis reporting highly atypical cells with prominent nucleoli of uncertain origin. CT showed extensive intrahepatic lesions throughout both lobes of the liver, and tumor markers were elevated with Ca19-9 16,581 kU/L, CEA 10 ug/L, Ca125 511 kU/L, and normal AFP. Repeat liver biopsy reported adenocarcinoma, likely cholangiocarcinoma, with background cirrhosis. Medical oncology did not feel he would tolerate chemotherapy, and he was thus discharged home with palliative supports. Conclusions HIPTs are benign lesions that are often initially misdiagnosed as malignancy, however this is the first case reporting progression of HIPT to cholangiocarcinoma. It is unclear if HIPT itself has premalignant potential, or whether its presence delays diagnosis of subsequent de novo malignancies. Given these uncertainties, as well as the lack of clarity on optimal management of HIPT, this case illustrates the importance of long-term clinical and radiographic follow up of these uncommon lesions, with consideration of repeat biopsy if the disease is not following the expected clinical course. Funding Agencies None

scholarly journals Bilateral auricular aneurysm with intact pericardial sac in a dog

2021 ◽  
Vol 14 (1) ◽  
pp. 46-49
Author(s):  
Aline Viott ◽  
◽  
Mayane Faccin ◽  
Mônica Matos ◽  
João Cavasin ◽  
...  
Keyword(s):  
Case Report ◽  
Connective Tissue ◽  
Physical Examination ◽  
Clinical Signs ◽  
Adequate Treatment ◽  
First Case ◽  
History Of

A nine-year-old, male, Pekingese dog was presented with a history of dyspnea, lethargy, syncope, polyuria, polydipsia, and selective appetite over two years. When the clinical signs first began, a radiographic exam revealed a radiopaque mass in the cranial mediastinum. An adequate treatment was not performed and the dog was presented to the hospital with severe tachycardia, dyspnea, and tachypnea, and died during physical examination. On necropsy, the heart presented bilateral auricular aneurysms. The pericardial sac was intact, and no other defects were found within the heart. Microscopically, the cardiomyocytes were marked degenerated and proliferation of connective tissue. This is the first case report of a bilateral auricular aneurysm with intact pericardial sac in a dog.

scholarly journals Hailey-Hailey Disease Treated Successfully with Acitretin

2021 ◽  
Vol 33 (2) ◽  
Keyword(s):  
Case Report ◽  
Skin Disease ◽  
Skin Lesions ◽  
Medical Illness ◽  
Once Daily ◽  
First Case ◽  
History Of

Hailey-Hailey disease (HHD) is a rare genodermatosis characterized by acantholysis and dyskeratosis of the intertriginous areas. This article presents the case of a 41-year-old Bahraini male, not known to have any medical illness, who presented with a two-year history of bilateral, painful, fissured skin lesions on the groin and axilla. The diagnosis of HHD was confirmed by biopsy. The patient was treated with a course of acitretin 25mg once daily orally for three months, and the treatment led to significant improvement. Up to date, this is the first case to be reported in Bahrain. The case report demonstrated the benefit of using acitretin in the management of HHD. Keywords: Acantholysis, Acitretin, Axilla, Benign Familial Pemphigus, Groin, Skin Disease

scholarly journals INVESTIGATIONS AND DIAGNOSIS OF GIANT PERIURETHRAL CONDYLOMA AND EFFICACY OF THE MANAGEMENT WITH CONVENTIONAL APPROACH: A CASE REPORT

2022 ◽  
Vol 29 (1) ◽  
Author(s):  
Stefanus Cahyo Ariwicaksono ◽  
Hendy Mirza
Keyword(s):  
Case Report ◽  
Physical Examination ◽  
Satisfactory Result ◽  
Conventional Approach ◽  
Pathological Examination ◽  
Rare Occurrence ◽  
Genital Area ◽  
First Case ◽  
History Of

Objective: This study aims to show our first case of female with periurethral condyloma and how we managed it. Case(s) Presentation: A 40-year-old female came with asymptomatic lesion in the genital area for 4 months, without any history of promiscuity. The physical examination showed a mass of 5 x 5 cm located in the periurethral area. The patient underwent mass excisions without any complication, further pathological examination confirmed the diagnosis of CA. Discussion: After operation and discharge there are no sign of recurrence after 6 months follow up. Conclusion: Despite the rare occurrence in periurethral region, clinicians should be aware of CA case in female and for our first case we used mass excision with satisfactory result.

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