INVESTIGATIONS AND DIAGNOSIS OF GIANT PERIURETHRAL CONDYLOMA AND EFFICACY OF THE MANAGEMENT WITH CONVENTIONAL APPROACH: A CASE REPORT

Objective: This study aims to show our first case of female with periurethral condyloma and how we managed it. Case(s) Presentation: A 40-year-old female came with asymptomatic lesion in the genital area for 4 months, without any history of promiscuity. The physical examination showed a mass of 5 x 5 cm located in the periurethral area. The patient underwent mass excisions without any complication, further pathological examination confirmed the diagnosis of CA. Discussion: After operation and discharge there are no sign of recurrence after 6 months follow up. Conclusion: Despite the rare occurrence in periurethral region, clinicians should be aware of CA case in female and for our first case we used mass excision with satisfactory result.

Development, preparation and characterization of chitosan, gelatin and heparin membranes for biomedical applications

With the rising in life expectancy and the consequent population aging, degenerative chronic diseases have been figured as the major cause of morbidity and mortality in the world. It is believed that the production of a polymeric matrix composed of chitosan and gelatin may be an alternative to obtain a carrier base of heparin, with the prospective objective of applying these materials as an alternative to the conventional therapeutic resources biomedical. Based on the results, it can be concluded that the interaction between chitosan, gelatin, and heparin demonstrating a satisfactory result by the methodologies that were applied, making the study hypothesis concrete., certifying the use of a methodology for including heparin in a biodegradable polymeric base. Thus, expanding the alternatives for possible alternatives to the conventional therapeutic resources of vascular diseases with the application of the developed materials.

Surgical treatment of blepharoptosis (literature review)

Blepharoptosis is currently a serious pathology, the treatment of which does not always bring a satisfactory result. The article provides a review of the literature, describes the methods of surgical treatment of this ophthalmopathology. Each method is distinguished by indications, outcomes, efficiency. The method of surgical intervention depends on the cause of ptosis, the function of the levator muscle, the patient's age, visual acuity and a number of other indicators, but the main criteria are the degree of preservation of the levator function and lowering of the upper eyelid. The classic algorithm for treating patients with blepharoptosis involves shortening the levator or suspending the muscle that raises the upper eyelid to the eyebrow. Key words: ptosis of the upper eyelid, resection of the levator, function of the levator, operations of suspending type.

Numerical Analysis of Evacuation Start in Pangandaran

Tsunami evacuations plan should consider the behavior of local people. In this study tsunami evacuation start was analyzed using tsunami evacuation simulation consist of evacuee generation and evacuee behavior model. Pangandaran west beach was selected as the target area due to its popularity as a tourist spot and fishery activities in West Java. Evacuation simulations were conducted using 500 evacuations agents with tsunami shelter and grand mosques as goal for the safer place. A total of six evacuation scenarios were made using a different set of evacuation triggers parameter value with the combination of influence weight and effective range. The simulation result indicates that the influence weight which made 57% of people start evacuation immediately after the earthquake happened showed an instantaneous evacuation. Simulation result that was using lower influence weight and lower exposure range showed a more gradual tsunami evacuation. The simulation gave promising results that Pangandaran people could be safely evacuating if they raise their awareness and preparedness. The low-cost simulations that were used in this study provide an insight into the behaviors of Indonesians during disaster evacuation and might use as support for tsunami evacuation planning. However, to produce more satisfactory result we need to conduct field survey and tsunami drill to gain more information of people behavior during tsunami evacuation.

Experiment Investigation On Concrete With Partial Replacement Of Cement By Cow Dung Ash

Experimental investigations were carried out to study the cow dung ash on the strength of concrete. Cement was partially replaced with four percentages (5%, 10%, 15%, 20%) of cow dung ash by weight in M20 grade concrete mix. Test performed on the concrete mix are compressive strength, splitting tensile strength and workability. The compressive strengths of the concrete specimens were determined at 7 and 28 days respectively. The tests were performed on the moulds of size (150mm x150mm x150mm).Workability test is done using compaction factor apparatus. Workability Test shows that workability of concrete decreases as percentage of cow dung ash increases in concrete mix. When compared to normal concrete the concrete containing 10% of CDA has 17% increase in compressive strength and 15% increase in Tensile Strength. The Compressive Strength and Tensile strength tends to decrease after 10%. Thus 10% replacement of cement by CDA gives satisfactory result.

Indications for hemithyroidectomy for nodular goiteragainst the background of autoimmune thyroiditis and prognosis of long-term results

Aim — to study the possibility of determining the indications for choice of the extent of surgery in patients with unilateral nodular goiteragainst the background of autoimmune thyroiditis(AIT) with compression syndrome and prognosis for the long-term results of surgical treatment.Materials and methods. The analysis has been performed for the long-term results of hemithyroidectomy in 101 women aged from 23 to 72, patients with unilateral nodular goiteragainst the AITbackground with compression syndrome. It has been established what exactly indications to the surgery,includingvolume of the gland, echostructure variant, blood levels of thyroid stimulating hormone(TSH), free thyroxine and triiodothyronine, thyroid peroxidase(TPO) antibodies, apoptosis and proliferation indicators, provided satisfactory and unsatisfactory treatment results.Results. Based on the results of investigation in 3 years after hemithyroidectomy, no violations of the functional state of the thyroid glandwere revealed in 75 patients; in them ultrasoundinvestigation of parenchyma of the remaining lobe of the gland showed that pre-operativeAITsigns did not progress or progressed without hypothyroidism and changes of the variant of ultrasound picture (satisfactory result). In 26 patients an increase in the volume of the remaining part of the thyroid gland and progression of the autoimmune process with the development of hypothyroidism were established (unsatisfactory result).One can expect the satisfactory result of hemithyroidectomy in the treatment of patients with unilateral nodular goiteragainst the AIT backgroundwith compression syndrome in cases where at the time of surgery the volume of the lobe does not exceed 10 cm3, its echostructure corresponds to hypoechoic and heterogeneous and pseudomicronodular variants, TSH is not higher than 2.85 IU/L, levels of free thyroxine and triiodothyronine are not lower than 16.7 and 5.3 pmol/l, respectively, TPO antibodies level is not higher than 150 IU/ml.Conclusions. One of the possible options for surgical treatment of patients with unilateral nodular goiteragainst the AIT background with compression syndrome may be hemithyroidectomy with preserved hormonal function of the gland and structural changes in the parenchyma in the lobe, which remains at the level of hypoechoic and heterogeneous or pseudomicrous variants. Hemithyroidectomy is contraindicated in cases of pseudolarge nodular and severe variants of parenchyma echostructure of the thyroid gland.

About primary gastric sarcoma

The only radical method of treatment of malignant neoplasms of the stomach today is surgical, surgical intervention. The results of such an intervention are closely related to how timely and. it is radically produced. It is therefore clear that in relation to malignant tumors of the stomach, it is not important to recognize the disease in general, but to early recognition, in which radical intervention can give a satisfactory result.

An Effective Prediction on COVID-19 Prevalence for India and Japan using Fbprophet Model

Coronavirus has become a significant concern for the whole world. It has had a substantial influence on our social and economic life. The infection rate is rapidly increasing at every moment throughout the world. At present, predicting coronavirus has become one of the challenging issues for us. As the pace of COVID-19 detection increases, so does the death rate. This research predicts the number of coronavirus detection and deaths using Fbprophet, a tool designed to assist in performing time series forecasting at a large scale. Two major affected countries, India and Japan, have been taken into consideration in our approach. Using the prophet model, a prediction is performed on the number of total cases, new cases, total deaths and new deaths. This model works considerably well, and it has given a satisfactory result that may help the authority in taking early and appropriate decisions depending on the predicted COVID situation.

Triple intramural dexamethasone injections increase the efficiency of endoscopic bougienage of esophageal re-stenosis and anastomosis

Purpose of the study. To analyze retrospectively our own experience of using intramural dexamethasone injections during endoscopic bougienage of recurrent or very tight (refractory) benign cicatricial strictures of the esophagus and esophageal anastomoses.Materials and methods. From 2013 to March 2021, this method was applied in 43 patients (26 — men, 17 — women) with peptic (11), cicatricial (8), burn (6) esophageal strictures and strictures of anastomoses (18) prone to restenosis. Dexamethasone was injected into the constricted area with a needle passed through the endoscope biopsy channel as an addition to supportive bougienage.Results. After dexamethasone injections, 41 (95.3%) of 43 patients achieved a satisfactory lumen diameter, at which the symptoms of dysphagia disappeared for a long time without relapse. In most patients, the lumen in the stricture zone stabilized at a diameter of 8–18 mm (average 13 mm). With strictures of the esophagus, it was possible to achieve a diameter of 8–14 mm (average 11 mm), and with strictures of the anastomoses — 10–18 mm (average 14 mm).Conclusion. With the tendency of stricture to restenosis, the standard algorithm for endoscopic bougienage, developed in the endoscopy department of the “Petrovsky National Research Center of Surgery”, was supplemented with intramural injections of dexamethasone. This combined endoscopic treatment made it possible to increase the diameter of the bougie and the intervals between bougienage due to the stabilization of the scar frame and to complete the endoscopic treatment with a satisfactory result in 95.3% of patients.

Choriocarcinoma brain metastasis in a patient in the third trimester: a case report

Background Metastatic choriocarcinoma in the third trimester of pregnancy is extremely rare. Case presentation A 25-year-old Chinese woman (gravida 3, para 0) who was 28 weeks pregnant was admitted for sudden convulsion, aconuresis, and unconsciousness. The decision was made to perform an emergency cesarean delivery and craniotomy, hematoma clearance, and decompression. Pathological examination confirmed choriocarcinoma with brain metastasis. The patient underwent chemotherapy with the etoposide, cisplatin (EP) and etoposide, methotrexate and dactinomycin alternating with cyclophosphamide and vincristine (EMACO) regimens. A satisfactory result was achieved. Conclusions When encountering intracranial mass or bilateral pulmonary nodules in a pregnant woman, especially one in the third trimester, metastatic choriocarcinoma should be considered.