scholarly journals Comparison of aortic pressures and aortic elastic properties between patients with end-stage renal disease and healthy controls

2019 ◽  
Vol 11 (2) ◽  
pp. 77-83 ◽  
Author(s):  
Macit Kalçık ◽  
Mucahit Yetim ◽  
Tolga Doğan ◽  
İbrahim Doğan ◽  
Barış Eser ◽  
...  
Keyword(s):  
Elastic Properties ◽  
End Stage Renal Disease ◽  
Aortic Stiffness ◽  
Aortic Distensibility ◽  
Ascending Aorta ◽  
Stiffness Index ◽  
Healthy Controls ◽  
Aortic Compliance ◽  
Stage Renal Disease ◽  
End Stage

Background Current evidence indicates that vascular calcification plays an essential role in the development of cardiovascular diseases in end-stage renal disease (ESRD) patients. Arterial stiffness is a marker of increased cardiovascular risk in various populations. The aim of this study is to evaluate the elastic properties of ascending aorta in patients with ESRD. Methods This single-center study enrolled 96 patients (45 females, age: 57.2 ± 12.8 years) with ESRD and 96 healthy controls (52 females, age: 55.3 ± 10.1 years). Aortic pressures and aortic elastic parameters including aortic strain, aortic distensibility, aortic stiffness index, and aortic compliance were calculated using accepted formulae. Results The hemodynamic parameters including aortic pulse pressure, aortic mean pressure, aortic fractional pulse pressure, and aortic pulsatility index were significantly higher in patients with ESRD. Systolic and diastolic aortic diameters were similar between the groups. However, pulsatile aortic diameter change, aortic strain, aortic distensibility, and aortic compliance were significantly lower, whereas aortic stiffness index was significantly higher in ESRD group. Conclusions The results demonstrated that a significant difference was present in terms of aortic blood pressures between patients with ESRD and controls. In addition, the elastic properties of ascending aorta were decreased in patients with ESRD.

EVALUATION OF ELASTIC PROPERTIES OF THE ASCENDING AORTA IN MALE TOBACCO ADDICTS BY ECHOCARDIOGRAPHY

2014 ◽  
pp. 71-76
Author(s):  
Minh Hoa Tran ◽  
Thi Thuy Hang Nguyen
Keyword(s):  
Elastic Properties ◽  
Aortic Stiffness ◽  
Cell Injury ◽  
Aortic Distensibility ◽  
Ascending Aorta ◽  
Aortic Diameter ◽  
Stiffness Index ◽  
Control Group ◽  
Chronic Smoking ◽  
Aortic Strain

Background: Cigarette smoking causes endothelial cell injury, loss of smoothness, elasticity, it would be easy to form plaques in the endothelium. Etude of elasticity of ascending aorta by echocardiography in male smokers contribute to the assessment of vascular changes through indices such as aortic strain, aortic stiffness, aortic distensibility. Aim: was to estimate the effects of chronic smoking on the elastic properties of the ascending aorta. Material and Methods: this study was carried on 180 male subject, 90 smokers, mean age 37.56 ± 7.31 and 90 healthy male non-smokers with similar age. They are all under echocardiography to measure systolic aortic diameter and diastolic aortic diameter, determine the indexes such as: aortic strain, aortic stiffness, aortic distensibility and blood pressure simultaneously. Results: strain index and aortic distensibility is significantly lower in smokers than the control group, whereas stiffness index in smokers is higher than the control group with p <0.001. Conclusions: In tobacco addicts, smoking change the elasticity of the aorta, so it is a predictor of cardiovascular risk factors. Keywords: Tobacco addicts, aortic elastic properties, echocardiography

SURVEY OF RELATIONSHIP BETWEEN SMOKING STATUS AND ELASTIC INDEXES OF THE ASCENDING AORTA BY ECHOCARDIOGRAPHY IN MALE TOBACCO ADDICTS

2014 ◽  
pp. 84-89
Author(s):  
Thi Thuy Hang Nguyen
Keyword(s):  
Elastic Properties ◽  
Aortic Stiffness ◽  
Smoking Status ◽  
Aortic Distensibility ◽  
Ascending Aorta ◽  
Stiffness Index ◽  
Control Group ◽  
Strain Index ◽  
Chronic Smoking ◽  
Aortic Strain

Background: Many studies has reported that chronic smoking affects arterial stiffness. Smoking causes changes in both peripheral and central blood vessel function, even in young or middle-aged smokers. Echocardiography is a noninvasive and simple test, simply, to help evaluate the elastic properties of ascending aorta through the indices such as aortic strain, aortic stiffness, aortic distensibility. Aim: To determine the association between smoking status and elastic indexes of the ascending aortia measured by echocardiography. Material and Methods: this study was carried on 180 male subject, 90 smokers, mean age 37.56 ± 7.31 years and 90 healthy male non-smokers with similar age. Echocardiography was done with the following indexes: systolic and diastolic aortic diameter, aortic strain, aortic stiffness, aortic distensibility and blood pressure. Relationship between these indexes and duration of smoking was determined. Results: In group of smoking <17 pack one year, the indices of aortic elasticity is not different from the control group, p> 0,05. In group of smoking ≥ 17 pack year, strain index and aortic distensibility are significantly lower than the control group, whereas stiffness index is higher than the control group with p <0.001. Strain index and aortic distensibility of the ascending aorta were negatively correlated with duration of smoking, with p <0.0001. Stiffness index is positively correlated with duration of smoking, with p <0.0001. Conclusions: Smoking have decreased ascending aortic distensibility compared to non-smokers in a manner is related to duration of smoking. Keywords: Duration of smoking, aortic elastic properties, echocardiography

Fibrin clot structure in patients with end-stage renal disease

2007 ◽  
Vol 98 (08) ◽  
pp. 339-345 ◽  
Author(s):  
Johannes Sidelmann ◽  
Mikkel Brabrand ◽  
Robert Pedersen ◽  
Jørgen Pedersen ◽  
Kim Esbensen ◽  
...  
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Healthy Controls ◽  
Structure Characteristics ◽  
Stage Renal Disease ◽  
End Stage ◽  
Esrd Patients ◽  
Fibrin Structure ◽  
Plasma Markers ◽  
Fibrin Clots

SummaryFibrin clots with reduced permeability, increased clot stiffness and reduced fibrinolysis susceptibility may predispose to cardiovascular disease (CVD). Little is known, however, about the structure of fibrin clots in patients with end-stage renal disease (ESRD).These patients suffer from a high risk of CVD in addition to their chronic low-grade inflammation. Using permeability, compaction and turbidity studies in 22 ESRD patients and 24 healthy controls, fibrin clots made from patient plasma were found to be less permeable (p<0.001), less compactable (p<0.001), and less susceptible to fibrinolysis (p<0.001) than clots from controls.The maximum rate of turbidity increase was also higher for the patients than controls (p<0.001), and scan-ning electron microscopy revealed higher clot density of fibrin fibers in clots from patients than clots from controls (p<0.001). Patients had higher plasma concentrations of fibrinogen, C-reative protein and interleukin 6 than controls.These plasma markers of inflammation correlated significantly with most of the fibrin structure characteristics observed in the patients. In contrast, plasma markers of azothemia showed no such correlations. The results suggest that in ESRD patients fibrin clots are significantly different from healthy controls, and that the fibrin structure characteristics in the patients are associated primarily with the inflammatory plasma milieu rather than with level of azothemia.

Aortic Stiffness and Diastolic Flow Abnormalities in End-Stage Renal Disease Assessed by Magnetic Resonance Imaging

2008 ◽  
Vol 109 (1) ◽  
pp. c1-c8 ◽  
Author(s):  
Arthur Doyle ◽  
Patrick B. Mark ◽  
Nicola Johnston ◽  
John Foster ◽  
John M.C. Connell ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Aortic Stiffness ◽  
Resonance Imaging ◽  
Diastolic Flow ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Risk Estimation of Aortic Stiffness in Patients with End Stage Renal Disease on Maintenance Haemodialysis

2019 ◽  
Vol 9 (1) ◽  
pp. 59-62
Author(s):  
Muhammad Abdur Razzak ◽  
Debasish Kumar Saha ◽  
Muhammad Ehsan Jalil ◽  
Mohammad Omar Faruque Miah ◽  
Abu Noim Md Abdul Hai ◽  
...  
Keyword(s):  
Renal Disease ◽  
Serum Calcium ◽  
End Stage Renal Disease ◽  
Aortic Stiffness ◽  
Serum Phosphate ◽  
Serum Phosphate Level ◽  
Maintenance Haemodialysis ◽  
Stage Renal Disease ◽  
End Stage ◽  
Esrd Patients

Background: The stiffness of the large elastic arteries increase the morbidity and mortality. The purpose of the present study was to estimate the risk of aortic stiffness among end stage renal disease patients on maintenance haemodialysis. Methods: This cross-sectional study was carried out in the Department of Nephrology at National Institute of Kidney Diseases and Urology (NIKDU), Dhaka and National Institute of Cardiovascular Disease and Hospital (NICVD), Dhaka, Bangladesh from January 2013 to December 2014 for a period of two years. Chronic kidney disease in stage 5 [CKD-5(D)] patients older than 18 years on maintenance haemodialysis (MHD) for more than 3 months were designated as case group and age and sex matched non CKD patients were considered as control group. Serum calcium, serum albumin, serum phosphate and iPTH were estimated by semi-automated biochemistry analyzer from the Department of Biochemistry of NIKDU, Dhaka and NICVD, Dhaka. Plain Xray abdomen in lateral view was performed for all patients. Result: A total number of 100 patients were enrolled for this study of which 50 patients were in end stage renal disease (ESRD) group and the rest 50 patients were in non-CKD group. Mean (±SD) aortic stiffness index was significantly higher (P<0.001) among ESRD population (3.27±1.70) compared to non CKD group of population (2.00±0.73). Mean (±SD) serum calcium (corrected) level was significantly high (P<0.001) in ESRD patients (9.79±0.87) compared to non CKD group of population (9.13±0.70). Mean (±SD) serum phosphate level was significantly higher (P<0.001) in ESRD patients (5.71±0.96) compared to non CKD group of population (4.20±0.59). However, mean (±SD) iPTH level showed no significant difference between ESRD (25.33±51.98) and non CKD group of population (38.53±19.52). Conclusion: In conclusion, aortic stiffness is significantly higher among ESRD subjects. Birdem Med J 2019; 9(1): 59-62

scholarly journals Inflammatory and metabolic profiles of patients with end-stage renal disease: potential strategy for predictive, preventive, and personalized medicine

2021 ◽  
Author(s):  
Xiaoxin Ma ◽  
Yongli Wang ◽  
Hongyu Wu ◽  
Fei Li ◽  
Xiping Feng ◽  
...  
Keyword(s):  
Personalized Medicine ◽  
End Stage Renal Disease ◽  
Healthy Controls ◽  
Preventive And Personalized Medicine ◽  
Hydroxyphenylacetic Acid ◽  
Potential Strategy ◽  
Stage Renal Disease ◽  
End Stage ◽  
Esrd Patients ◽  
And Personalized Medicine

Abstract Objectives Few studies reported the periodontal disease-related metabolic profile of end-stage renal disease (ESRD) patients. The present study aimed to compare the inflammatory and metabolic differences between patients with ESRD and healthy controls, and to identify potential useful biomarkers for predictive, preventive, and personalized medicine (PPPM) in GCP and serum of ESRD patients.Methods Patients with ESRD (ESRD group; n = 52) and healthy controls (HC group; n = 44) were recruited. Clinical periodontal parameters were recorded. The differential metabolites in the GCF and serum were identified by liquid chromatography/mass spectrometry. Inflammatory markers including Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Interleukin-8 (IL-8) and C-reactive protein (CRP) were also assessed. Results In ESRD group, IL-8 and CRP were significantly higher in GCF, whereas IL-6 and CRP were significantly higher in serum, compared with HC group (all P < 0.05). In the case of GCF, taurine levels were positively correlated with IL-8 levels in both groups (all P < 0.05). In the case of serum, L-phenylalanine and p-hydroxyphenylacetic acid levels were positively correlated with CRP levels in both groups (all P < 0.05). Significant positive correlation was observed between pseudouridine and IL-6 levels only in ESRD group. Conclusions IL-8 and CRP were potential inflammatory makers. Metabolites of taurine in GCF as well as L-phenylalanine and p-hydroxyphenylacetic acid in serum were possible biomarkers that correlated with inflammatory cytokine. All these biomarkers may consider as a potential strategy for the prediction, diagnosis, prognosis, and management of personalized periodontal therapy in the population with ESRD.

scholarly journals Pharmacologic Therapies for Aortic Stiffness in End-Stage Renal Disease: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 7 ◽  
pp. 205435812090697
Author(s):  
Rosendo A. Rodriguez ◽  
Matthew Spence ◽  
Richard Hae ◽  
Mohsen Agharazii ◽  
Kevin D. Burns
Keyword(s):  
Systematic Review ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Aortic Stiffness ◽  
Meta Analysis ◽  
Quality Of Evidence ◽  
Randomized Studies ◽  
Stage Renal Disease ◽  
End Stage

Background: Increased carotid-femoral pulse wave velocity (cf-PWV), a surrogate of increased aortic stiffness, is a risk factor for cardiovascular events and all-cause mortality in end-stage renal disease (ESRD). To minimize the deleterious effects of an increased aortic stiffness in ESRD patients, several interventions have been developed and cf-PWV has been used to monitor responses. Objective: The aim of this study was to determine the effects of pharmacologic interventions that target aortic stiffness on cf-PWV and systolic blood pressure (SBP) in adults with ESRD. Study design: This study implements a systematic review and meta-analysis. Data sources: MEDLINE, EMBASE, Cochrane Central, Health Technology Assessment, and EBM databases were searched. Study eligibility, participants, and interventions: Randomized and non-randomized studies involving adults (>18 years) with ESRD of any duration, receiving or not renal replacement therapy (hemodialysis, peritoneal dialysis) and exposed to a pharmacologic intervention whose effects were assessed by cf-PWV. Methods: Study screening, selection, data extraction, and quality assessments were performed by 2 independent reviewers. Narrative synthesis and quantitative data analysis summarized the review. Results: We included 1027 ESRD participants from 13 randomized and 5 non-randomized studies. Most pharmacologic interventions targeted bone mineral metabolism disorder or hypertension. Treatment with vitamin D analogues or cinacalcet did not decrease cf-PWV or SBP over placebo or matched controls ( P > .05). Calcium-channel blockers (CCB) decreased cf-PWV and SBP compared with placebo or standard care ( P < .05). Renin-angiotensin system inhibitors did not show any advantage over placebo in decreasing cf-PWV ( P > .05). Limitations: Quality of evidence ranged from very low to moderate. Overall evidence was limited by the low number of studies, small sample sizes, and methodological inconsistencies. Conclusions: Pharmacologic interventions targeting aortic stiffness in ESRD have mixed effects on reducing cf-PWV, with some strategies suggesting potential benefit. The quality of evidence, however, is insufficient to draw definitive conclusions on their use to slow progression of aortic stiffness in ESRD. Further well-designed studies are needed to confirm these associations and their impact on cardiovascular outcomes in ESRD. Registered in PROSPERO (CRD42016033463)

The Relationship Between Serum Endocan Level and Aortic Elastic Properties in Patients With Newly Diagnosed Essential Hypertension

Angiology ◽  
2019 ◽  
Vol 70 (7) ◽  
pp. 662-668 ◽  
Author(s):  
Mustafa Çelik ◽  
Erdoğan Sökmen ◽  
Serkan Sivri ◽  
Cahit Uçar ◽  
Rukiye Nar ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Elastic Properties ◽  
Aortic Stiffness ◽  
Surrogate Marker ◽  
Aortic Distensibility ◽  
Stiffness Index ◽  
Newly Diagnosed ◽  
The Relationship ◽  
Aortic Elastic Properties ◽  
Aortic Strain

Endothelial dysfunction plays role in the generation of both essential hypertension (EH) and aortic stiffness. We evaluated the relationship between serum endocan level and aortic elastic properties (AEPs) assessed with the aortic strain, aortic distensibility, and aortic stiffness index by echocardiography. Newly diagnosed EH patients (n = 67) and controls (n = 70) were included in the study. The EH group was subdivided into stage 1 and 2 EH groups. A higher endocan level was found in the EH group, compared to the controls (34.2 ± 13.0 vs 24.1 ± 7.3 ng/mL, respectively, P < .001). All the AEP parameters were worse in the EH group, compared to the controls. Further, endocan levels correlated with aortic distensibility ( r = −0.305, P < .001) and aortic strain ( r = −0.181, P = .038), but not with aortic stiffness index ( r = 0.162, P = .064) in the whole study population. Aortic elastic properties deteriorate and serum endocan level increases in patients with EH. Moreover, serum endocan level shows a correlation with deteriorated AEPs, and hence may a surrogate marker of escalating aortic stiffness in patients with newly diagnosed EH.

Immunodiagnosis and molecular validation of Toxoplasma gondii infection among patients with end-stage renal disease undergoing haemodialysis

Parasitology ◽  
2019 ◽  
Vol 146 (13) ◽  
pp. 1683-1689 ◽  
Author(s):  
Zahra Arab-Mazar ◽  
Shirzad Fallahi ◽  
Davood Yadegarynia ◽  
Amirreza Javadi Mamaghani ◽  
Seyyed Javad Seyyed Tabaei ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Immunoglobulin M ◽  
Enzyme Linked Immunosorbent Assay ◽  
Healthy Controls ◽  
Blood Samples ◽  
Igm Antibodies ◽  
Stage Renal Disease ◽  
End Stage

AbstractInfection is a significant cause of morbidity and mortality in patients with chronic kidney disease, especially who were under dialysis due to their depressed immunity. Toxoplasma gondii is a ubiquitous parasite that causes severe manifestations in immunocompromised patients. This case-control study was conducted to the immunodiagnosis and molecular validation of T. gondii infection among patients with end-stage renal disease undergoing haemodialysis. The study population consisted of 260 haemodialysis patients and 259 healthy controls referred to the main dialysis centres of Tehran, Iran during 2016. Anti-T. gondii immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies were assessed using enzyme-linked immunosorbent assay. As well, the T. gondii genomic DNA in whole blood samples of IgM-positive patients and healthy controls was evaluated using GRA6-polymerase chain reaction (PCR) and SAG1-loop-mediated isothermal amplification (LAMP) assays. The anti-T. gondii IgG and IgM antibodies were detected in 175 (67.3%) and 18 (7%) of haemodialysis patients and 122 (47%) and 4 (1.5%) of controls, respectively. Two of the 18 blood samples from IgM-positive patients and none of the IgM-positive control subjects were positive by GRA6-PCR. Whereas, nine and two blood samples of IgM-positive patients and controls were positive for Toxoplasma DNA by a SAG1-LAMP technique respectively. The seropositivity of the Toxoplasma IgM antibody was significantly different between haemodialysis patients and healthy controls which was confirmed by PCR and LAMP. The higher prevalence of T. gondii infection in haemodialysis patients compared with the controls proposes that these patients can be a group at risk for toxoplasmosis and screening for toxoplasmosis before dialysis is necessary for the patients.

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