scholarly journals Extrahepaticus manifesztációk idült hepatitis C-vírus-fertőzöttekben

2017 ◽  
Vol 158 (16) ◽  
pp. 603-611
Author(s):  
Krisztina Hagymási ◽  
Anna Egresi ◽  
Gabriella Lengyel
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Antiviral Agents ◽  
Extrahepatic Manifestations ◽  
Hepatitis C Infection ◽  
Extrahepatic Manifestation ◽  
Direct Antiviral Agents

Abstract: The importance of chronic hepatitis C infection is significant. 3% of the World’s population is infected. There is at least one extrahepatic manifestation in 50% of HCV patients, which makes the prognosis and mortality worse. The pathomechanisms included are cryoglobulin production, immunmechanisms, and direct viral effects. The authors summarize the main extrahepatic manifestations, as well as treatment possibilities. The aim is to draw attention to this colourful infection in order to improve the recognition in the era of the new effective direct antiviral agents. Orv. Hetil., 2017, 158(16), 603–612.

scholarly journals Vitamin D in Patients with Chronic Hepatitis C Virus Infection Receiving the Direct Antiviral Agents

2020 ◽  
Vol 4 (1) ◽  
pp. 1-4
Author(s):  
Hsuan-Wei Chen ◽  
Hsuan-Hwai Lin ◽  
Yu-Lueng Shih ◽  
Tsai-Yuan Hsieh ◽  
Jung-Chun Lin ◽  
...  
Keyword(s):  
Vitamin D ◽  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Chronic Hepatitis C ◽  
Antiviral Agents ◽  
Hepatitis C Virus Infection ◽  
Chronic Hepatitis C Virus ◽  
Direct Antiviral Agents

The Effects of Interferon and Ribavirin in Chronic Hepatite C

2017 ◽  
Vol 68 (9) ◽  
pp. 2147-2150
Author(s):  
Liliana Coldea ◽  
Florin Grosu ◽  
Alina Liliana Pintea ◽  
Sebastian Ioan Cernusca Mitariu ◽  
Nicolae Grigore ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Antiviral Treatment ◽  
Public Health Problem ◽  
Complete Response ◽  
Extrahepatic Manifestations ◽  
Hépatite C ◽  
Response Versus

The chronic hepatitis C is a frequently problem in worldwide, the number of infected individuals is high and go on, getting a public health problem [1]. In Romania there are nearly 1 million persons infected with hepatitis C virus, the scope of spreading is related with specific risk factors. An important number of infection with hepatitis C virus present simultaneous extrahepatic manifestations proved to be alone manifestation tracing; its important for diagnosis and treatment. We analyzed the effects of interferon and ribavirin in chronic hepatitis C in General C.F. Hospital Sibiu, between 2008 � 2012. The association between infection with hepatitis C virus and extrahepatic manifestations is important to be recognized for adequate diagnosis tests. By comparing the results of therapy in patients with hepatic and extrahepatic manifestations, the study found that 30 patients (58.83 %) with liver manifestations had an incomplete response versus 10 patients (26.32 %) with extrahepatic manifestations; 11 patients (21.54 %) with hepatic manifestations had a complete response versus 3 patients (7.89 %) with extrahepatic manifestations; and 10 patients (19.63 %) with hepatic manifestations did not respond to treatment versus 25 patients (65.79 %) with extrahepatic manifestations. Analyzing the results of antiviral therapy in patients with hepatic manifestations and those with extrahepatic manifestations, antiviral treatment appears to be more advantageous in cases with only hepatic manifestations.

scholarly journals Hepatitis C virus vaccine development: old challenges and new opportunities

2015 ◽  
Vol 2 (3) ◽  
pp. 285-295 ◽  
Author(s):  
Dapeng Li ◽  
Zhong Huang ◽  
Jin Zhong
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Vaccine Development ◽  
Rna Virus ◽  
Antiviral Agents ◽  
Resistance Mutations ◽  
Direct Acting Antiviral ◽  
Direct Acting

Abstract Hepatitis C virus (HCV), an enveloped positive-sense single-stranded RNA virus, can cause chronic and end-stage liver diseases. Approximately 185 million people worldwide are infected with HCV. Tremendous progress has been achieved in the therapeutics of chronic hepatitis C thanks to the development of direct-acting antiviral agents (DAAs), but the worldwide use of these highly effective DAAs is limited due to their high treatment cost. In addition, drug-resistance mutations remain a potential problem as DAAs are becoming a standard therapy for chronic hepatitis C. Unfortunately, no vaccine is available for preventing new HCV infection. Therefore, HCV still imposes a big threat to human public health, and the worldwide eradication of HCV is critically dependent on an effective HCV vaccine. In this review, we summarize recent progresses on HCV vaccine development and present our views on the rationale and strategy to develop an effective HCV vaccine.

scholarly journals Improvement of insulin sensitivity in diabetic and non diabetic patients with chronic hepatitis C treated with direct antiviral agents

PLoS ONE ◽  
2018 ◽  
Vol 13 (12) ◽  
pp. e0209216 ◽  
Author(s):  
Alessandro Gualerzi ◽  
Mattia Bellan ◽  
Carlo Smirne ◽  
Margherita Tran Minh ◽  
Cristina Rigamonti ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Insulin Sensitivity ◽  
Chronic Hepatitis C ◽  
Antiviral Agents ◽  
Diabetic Patients ◽  
Direct Antiviral Agents
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