Modern TLC: A key technique for identification and quality control of botanicals and dietary supplements

2005 ◽  
Vol 18 (101) ◽  
pp. 34-38 ◽  
Author(s):  
Anne Schibli ◽  
Eike Reich
Keyword(s):  
Quality Control ◽  
Dietary Supplements

scholarly journals Optimization of spectrophotometric method for determination nattokinase activity in dietary supplements

2020 ◽  
Vol 3 (2) ◽  
pp. 96-103
Author(s):  
Dieu Thu Nguyen Thi ◽  
Dung Hoang Viet ◽  
Hong Ngoc Nguyen Thi ◽  
Thanh An Vu Thi ◽  
Thanh Hoa Mac Thi ◽  
...  
Keyword(s):  
Quality Control ◽  
Reaction Time ◽  
Dietary Supplements ◽  
Dietary Supplement ◽  
Reaction Temperature ◽  
Spectrophotometric Method ◽  
Fibrinolytic Activity ◽  
Valuable Contribution ◽  
Label Product ◽  
Measured Activity

Nattokinase is an enzyme with a strong fibrinolytic activity that can be used for preventing thrombolytic diseases. The fibrinolytic activity of the Nattokinase in dietary supplements is determined by spectrophotometric method. In this study, the conditions of the assay were examined and finally optimized as pH: 8.5, reaction temperature: 40oC, and reaction time: 60 minutes. The proposed method was validated and successfully applied to determine the Nattokinase activity in 10 dietary supplements. The results showed that the proportion of measured activity compared to label product activity were within in the range 79.1 - 98.0%. The effect of herbal compounds and excipients on Nattokinase activity were also surveyed. From the evaluated results and application to commercial samples, this method will be a valuable contribution to quality control of dietary supplement products containing Nattokinase.  

scholarly journals Development of the Analytical Methods and Reference Materials Program for Dietary Supplements at The National Institutes of Health

2004 ◽  
Vol 87 (1) ◽  
pp. 162-165 ◽  
Author(s):  
Leila G Saldanha ◽  
Joseph M Betz ◽  
Paul M Coates
Keyword(s):  
Quality Control ◽  
Dietary Supplements ◽  
Reference Materials ◽  
Analytical Methods ◽  
Research Agenda ◽  
Control Unit ◽  
Lessons Learned ◽  
National Institutes Of Health ◽  
Good Manufacturing Practices ◽  
The U.S

Abstract The need for validated analytical methods and reference materials to identify and measure constituents in dietary supplements is essential. Such methods allow for the documentation that products meet manufacturer's specifications and contain what their labels declare. In March 2003, the U.S. Food and Drug Administration issued a proposed rule that would establish specific current good manufacturing practices for dietary supplements. This proposed rule requires that companies create a quality control unit to set specifications and ensure compliance with these specifications using scientifically valid procedures. This report provides insights and lessons learned from 3 meetings the Office of Dietary Supplements (ODS) at the National Institutes of Health helped organize. These meetings were structured to (1) educate individuals about the importance and need for validated analytical methods and reference materials to identify and quantify constituents of dietary supplements; (2) identify resources required to fulfill this need; and (3) serve as a platform to obtain input from interested parties to help frame the research agenda for the Dietary Supplements Methods and Reference Materials Program within ODS. Stakeholder's opinions and views expressed at these 3 meetings are outlined in this report.

scholarly journals Retrospective analysis and current state of the improving qualification of pharmacists on quality questions of medicines in Shupyk NMAPE

2019 ◽  
pp. 24-36
Author(s):  
S. H. Ubohov ◽  
L. B. Pilipchuk ◽  
V. I. Todorova ◽  
A. P. Radchenko ◽  
L. O. Fedorova ◽  
...  
Keyword(s):  
Quality Control ◽  
Quality Assurance ◽  
Dietary Supplements ◽  
Retrospective Analysis ◽  
Scientific Activity ◽  
Biologically Active ◽  
Analytical Control ◽  
Active Ingredients ◽  
Scientific Publications ◽  
Current State

To date, one of the advanced educational and research centers of Kiev and Ukraine, which is the improving qualification of pharmacists on quality questions of medicines, is the Department of Quality Control and Standardization of Medicines of Shupyk National Medical Academy of Post-Graduate Education (NMAPE). The aim of the work is to analyze the historical stages of formation and development of the Department of Quality Control and Standardization of Medicines of Shupyk NMAPE. The materials of the research are: archival and current documentation of the department, scientific publications, encyclopedic reference materials. Studies were conducted using methods: content analysis, historical documentary, generalization and systematization of historical data. In this work a retrospective analysis was performed and current state of activity of the Department of Quality Control and Standardization of Medicines of Shupyk NMAPE was considered. The basic stages of formation and historical development of the department during 1938 to 2018 are determined. The contribution to the development of pharmaceutical education and science of professors (prof. Ya.A. Fialkov, N.P. Maksyutina, O.M Gritsenko, N.O. Vetiutneva, etc.) was noted. The educational cycles, taught at the department, are shown, namely: specialization cycles, internships, pre-certification training in the specialties «Analytical Control Pharmacy», «General Pharmacy»; thematic improvement cycles on topical issues of pharmacy, quality assurance and prevention of falsification of medicines, functioning of quality systems of pharmacies (for pharmacists); cycles of improvement of assistant pharmacists; thematic improvement cycles on the scientific basis of phytotherapy and the use of modern medicines based on active ingredients of natural origin (for physicians). The basis of educational-methodical and scientific production of the department is described. The main areas of the scientific activity of the department are described, covering the following areas: development of methods for the investigation of complex synthetic compounds, methods for express analysis of extemporal multicomponent medicines, methods for quality control the of phytotherapeutic and homeopathic medicines; study of the composition and intermolecular interaction of biologically active compounds in plants and phytopreparations; synthesis and creation of new medicines and dietary supplements; study of the properties of crown compounds; study of the interaction of auxiliary substances with active ingredients; research on increasing the solubility of difficult soluble substances; substantiation of methodological and organizational-methodical principles of quality assurance of medicines at stages of wholesale, retail sale and medical use, etc. Analysis of the activities of the Department of Quality Control and Standardization of Medicines of Shupyk NMAPE during 1938 to 2018 testifies to its significant contribution and great potential for the development of pharmaceutical science and practice, in particular in the direction of the creation, standardization, assurance and control of quality of medicines and dietary supplements.

scholarly journals Evaluation of Thin-Layer Chromatography Methods for Quality Control of Commercial Products Containing Aesculus hippocastanum, Turnera diffusa, Matricaria recutita, Passiflora incarnata, and Tilia occidentalis

2007 ◽  
Vol 90 (4) ◽  
pp. 920-924 ◽  
Author(s):  
Rosalba RAMÍREZ-DURÓN ◽  
LucÍa Ceniceros-Almaguer ◽  
Ricardo Salazar-Aranda ◽  
Ma De La Luz Salazar-Cavazos ◽  
Noemi Waksman De Torres
Keyword(s):  
Quality Control ◽  
Thin Layer ◽  
Dietary Supplements ◽  
Thin Layer Chromatography ◽  
Aesculus Hippocastanum ◽  
Commercial Products ◽  
Matricaria Recutita ◽  
Turnera Diffusa ◽  
Passiflora Incarnata ◽  
Layer Chromatography

Abstract In Mexico, plant-derived products with health claims are sold as herbal dietary supplements, and there are no rules for their legal quality control. Aesculus hippocastanum, Turnera diffusa, Matricaria recutita, Passiflora incarnata, and Tilia occidentalis are some of the major commercial products obtained from plants used in this region. In this paper, we describe the effectiveness of thin-layer chromatography methods to provide for the quality control of several commercial products containing these plants. Standardized extracts were used. Of the 49 commercial products analyzed, only 32.65% matched the chromatographic characteristic of standardized extracts. A significant number of commercial products did not match their label, indicating a problem resulting from the lack of regulation for these products. The proposed methods are simple, sensitive, and specific and can be used for routine quality control of raw herbals and formulations of the tested plants. The results obtained show the need to develop simple and reliable analytical methods that can be performed in any laboratory for the purpose of quality control of dietary supplements or commercial herbal products sold in Mexico.

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