Two faces of an illness: ankylosing spondylitis developed after rheumatoid arthritis

2009 ◽  
Vol 150 (43) ◽  
pp. 2000-2003
Author(s):  
Eszter Varga ◽  
Ágnes Petró ◽  
Rita Jáger ◽  
László Varga
Keyword(s):  
Rheumatoid Arthritis ◽  
Ankylosing Spondylitis ◽  
Hla B27 ◽  
Hla Dr ◽  
Spondylarthritis Ankylopoetica

A szerzők egy 35 éves nőbeteg kórtörténetét ismertetik, akinél 29 éves korában szeronegatív rheumatoid arthritist igazoltak a reumatológiai osztályon. A betegség remisszióját sikeres graviditás követte, majd két évvel később kizárólag axiális tüneteket mutató spondylarthritist diagnosztizáltak. A major hisztokompatibilitási komplex vizsgálata során a hagyományos szerológiai módszerekkel a HLA B27 spondylarthritis ankylopoeticára jellemző, valamint HLA DR1 rheumatoid arthritisre jellemző haplotípust mutattak ki. A HLA DRB-polimorfizmus vizsgálata során a rheumatoid arthritis létrejöttében és kórlefolyásában szerepet játszó HLA DR B1 0101 allél jelenlétét igazolták. A betegben tehát ritka kombinációként a spondylarthritis ankylopoetica és a rheumatoid arthritis létrejöttében is szerepet játszó HLA-formáció egyaránt megtalálható volt.

Using internet search data to explore the global public concerns in ankylosing spondylitis

2020 ◽  
pp. postgradmedj-2019-137407
Author(s):  
Yong-Jun Mei ◽  
Yan-Mei Mao ◽  
Fan Cao ◽  
Tao Wang ◽  
Zhi-Jun Li
Keyword(s):  
Rheumatoid Arthritis ◽  
Ankylosing Spondylitis ◽  
Public Interest ◽  
Global Scale ◽  
Hla B27 ◽  
Internet Search ◽  
Search Volume ◽  
Significant Seasonal Variation ◽  
Search Data ◽  
Public Concerns

ObjectiveThis study explored the changes of global public interest in internet search of ankylosing spondylitis (AS) based on Google Trends (GT) data, in order to reflect the characteristics of AS itself.MethodsGT was used to obtain the search popularity scores of the term ’AS’ on a global scale, between January 2004 and December 2018, under the ’health’ classification. Based on the global search data of AS provided by GT, the cosinor analysis was used to test whether there was seasonality in AS.ResultsIn general, AS related search volume demonstrated a decreasing trend from January 2004 to December 2014 and then remain stable from January 2015 to December 2018. No obvious seasonal variations were detected in AS related search volume (amplitude=1.54; phase: month=3.9; low point: month=9.9; p>0.025), which peaked in April and bottomed out in October. The top 17 rising topics were adalimumab, spondylolisthesis, Morbus, Vladimir Mikhailovich Bekhterev, autoimmune disease, rheumatoid arthritis, ankylosis, HLA- B27 positive, Crohn’s disease, rheumatology, spondylosis, arthritis, uveitis, rheumatism, sacroiliac, psoriatic arthritis and spondylitis.ConclusionsGlobally, there is no significant seasonal variation in GT for AS. The top fast-growing topics related to AS may be beneficial for doctors to provide targeted health education of the disease to patients and their families.

HLA-B27 is a Risk Factor for Rheumatoid Arthritis: Suggestion for an Evidence-based Update

2020 ◽  
Vol 17 (1) ◽  
pp. 7-10
Author(s):  
Seyyed Amir Yasin Ahmadi ◽  
Reza Mohammadrezaei-Khorramabadi ◽  
Saber Abbaszadeh ◽  
Jafar Rezaian ◽  
Farhad Shahsavar
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factor ◽  
Ankylosing Spondylitis ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Human Leukocyte ◽  
Evidence Based ◽  
Hla B27 ◽  
Leukocyte Antigen ◽  
And Personalized Medicine

Previously, the association of human leukocyte antigen (HLA)-B27 with ankylosing spondylitis has been investigated as original and meta-analysis studies. However, the association of HLA-B27 with rheumatoid arthritis is not currently investigated as a meta-analysis. Hence, in this letter, a brief meta-analysis on this association will be performed. Although there were some studies on the association of RA and HLA-B27, however, there was not a pooled odds ratio reported in textbooks. Based on this brief metaanalysis, number 2.687 can be reported as the odds ratio of this association. It shows that this association is neither sensitive nor specific, but can be an idea for pharmacogenomics and personalized medicine as a potential risk factor. Such other associations should be reported numerically and updated in textbooks.

Association of hla-b39 with hla-b27-negative ankylosing spondylitis and pauciarticular juvenile rheumatoid arthritis in japanese patients

1995 ◽  
Vol 38 (11) ◽  
pp. 1672-1677 ◽  
Author(s):  
Akihiro Yamaguchi ◽  
Naoyuki Tsuchiya ◽  
Hiroshi Mitsui ◽  
Michiko Shiota ◽  
Atsuko Ogawa ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Ankylosing Spondylitis ◽  
Juvenile Rheumatoid Arthritis ◽  
Japanese Patients ◽  
Hla B27

scholarly journals HLA alleles associated with risk of ankylosing spondylitis and rheumatoid arthritis influence the gut microbiome

2019 ◽  
Author(s):  
Mark Asquith ◽  
Peter R. Sternes ◽  
Mary-Ellen Costello ◽  
Lisa Karstens ◽  
Sarah Diamond ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Ankylosing Spondylitis ◽  
Gut Microbiome ◽  
Marker Gene ◽  
Intestinal Microbiome ◽  
Hla B27 ◽  
Microbial Composition ◽  
Hla Alleles ◽  
Microbiome Composition ◽  
Stool Samples

ABSTRACTObjectivesHLA alleles affect susceptibility to more than 100 diseases, but the mechanisms to account for these genotype-disease associations are largely unknown. HLA-alleles strongly influence predisposition to ankylosing spondylitis (AS) and rheumatoid arthritis (RA). Both AS and RA patients have discrete intestinal and faecal microbiome signatures. Whether these changes are cause or consequence of the diseases themselves is unclear. To distinguish these possibilities, we examine the effect ofHLA-B27andHLA-DRB1RA-risk alleles on the composition of the intestinal microbiome in healthy individuals.Methods568 samples from 6 intestinal sites were collected from 107 otherwise healthy unrelated subjects and stool samples from 696 twin pairs from the TwinsUK cohort. Microbiome profiling was performed using sequencing of the 16S rRNA bacterial marker gene. All patients were genotyped using the Illumina CoreExome SNP microarray, and HLA genotypes were imputed from these data.ResultsAssociation was observed betweenHLA-B27genotype, and RA-riskHLA-DRB1alleles, and overall microbial composition (P=0.0002 and P=0.00001 respectively). These associations were replicated in the TwinsUK cohort stool samples (P=0.023 and P=0.033 respectively).ConclusionsThis study shows that the changes in intestinal microbiome composition seen in AS and RA are at least partially due to effects ofHLA-B27and –DRB1on the gut microbiome. These findings support the hypothesis that HLA alleles operate to cause or increase the risk of these diseases through interaction with the intestinal microbiome, and suggest that therapies targeting the microbiome may be effective in their prevention and/or treatment.

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