Plasma Surface Modification in Biomedical Applications

1995 ◽  
Vol 414 ◽  
Author(s):  
I-H Loh ◽  
M-S Sheu
Keyword(s):  
Surface Modification ◽  
Biomedical Applications ◽  
High Energy ◽  
Glow Discharge Plasma ◽  
Specific Chemical ◽  
Plasma Surface Modification ◽  
Plasma Surface ◽  
Biomaterial Surfaces

AbstractSynthetic biomaterials are widely used for a variety of in vivo and in vitro biomedical applications. However, the performance, safety, and cost effectiveness of medical products are determined by desirable interactions between the physiological environments and biomaterial surfaces. Hence, development of surface modifications for biomaterials is strongly demanded by the biomedical industry. High energy techniques, such as glow discharge plasma, have been developed to impart specific chemical functionality to the biomaterial surfaces or to deposit new polymer films with desired properties. The use of plasma surface modification for biomedical applications is reviewed in this paper.

Enhancing tissue integration and angiogenesis of a novel nanocomposite polymer using plasma surface polymerisation, an in vitro and in vivo study

2016 ◽  
Vol 4 (1) ◽  
pp. 145-158 ◽  
Author(s):  
Michelle F. Griffin ◽  
Robert G. Palgrave ◽  
Alexander M. Seifalian ◽  
Peter E. Butler ◽  
Deepak M. Kalaskar
Keyword(s):  
Surface Modification ◽  
In Vivo Study ◽  
Plasma Surface Modification ◽  
Plasma Surface ◽  
Tissue Integration ◽  
Nanocomposite Polymer

Enhancing tissue integration and angiogenesis of a novel nanocomposite polymer using plasma surface modification, an in vitro and in vivo study.

Plasma surface modification of titanium by TiB precipitation for biomedical applications

2011 ◽  
Vol 206 (2-3) ◽  
pp. 330-337 ◽  
Author(s):  
A. Miklaszewski ◽  
M.U. Jurczyk ◽  
K. Jurczyk ◽  
M. Jurczyk
Keyword(s):  
Surface Modification ◽  
Biomedical Applications ◽  
Plasma Surface Modification ◽  
Plasma Surface ◽  
Modification Of Titanium

Plasma Surface Modification of Biomaterials for Biomedical Applications

2017 ◽  
pp. 95-166 ◽  
Author(s):  
Ajinkya M. Trimukhe ◽  
Krishnasamy N Pandiyaraj ◽  
Anuj Tripathi ◽  
Jose Savio Melo ◽  
Rajendra R. Deshmukh
Keyword(s):  
Surface Modification ◽  
Biomedical Applications ◽  
Plasma Surface Modification ◽  
Plasma Surface

scholarly journals Biocompatibility of SU-8 and Its Biomedical Device Applications

Micromachines ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 794
Author(s):  
Ziyu Chen ◽  
Jeong Bong Lee
Keyword(s):  
Surface Modification ◽  
Biomedical Applications ◽  
Pressure Sensors ◽  
Cell Encapsulation ◽  
Slight Modification ◽  
Biomedical Devices ◽  
Surface Modification Techniques ◽  
Negative Tone

SU-8 is an epoxy-based, negative-tone photoresist that has been extensively utilized to fabricate myriads of devices including biomedical devices in the recent years. This paper first reviews the biocompatibility of SU-8 for in vitro and in vivo applications. Surface modification techniques as well as various biomedical applications based on SU-8 are also discussed. Although SU-8 might not be completely biocompatible, existing surface modification techniques, such as O2 plasma treatment or grafting of biocompatible polymers, might be sufficient to minimize biofouling caused by SU-8. As a result, a great deal of effort has been directed to the development of SU-8-based functional devices for biomedical applications. This review includes biomedical applications such as platforms for cell culture and cell encapsulation, immunosensing, neural probes, and implantable pressure sensors. Proper treatments of SU-8 and slight modification of surfaces have enabled the SU-8 as one of the unique choices of materials in the fabrication of biomedical devices. Due to the versatility of SU-8 and comparative advantages in terms of improved Young’s modulus and yield strength, we believe that SU-8-based biomedical devices would gain wider proliferation among the biomedical community in the future.

Biological and biomedical applications of collagenous biomaterials

1990 ◽  
Vol 48 (3) ◽  
pp. 856-857
Author(s):  
Yasushi P. Kato ◽  
Michael G. Dunn ◽  
Frederick H. Silver ◽  
Arthur J. Wasserman
Keyword(s):  
Biomedical Applications ◽  
Soft Tissues ◽  
Collagen Fibers ◽  
Bone Collagen ◽  
Cover Slip ◽  
Fibroblast Migration ◽  
Cellular Expression ◽  
Defect Repair

Collagenous biomaterials have been used for growing cells in vitro as well as for augmentation and replacement of hard and soft tissues. The substratum used for culturing cells is implicated in the modulation of phenotypic cellular expression, cellular orientation and adhesion. Collagen may have a strong influence on these cellular parameters when used as a substrate in vitro. Clinically, collagen has many applications to wound healing including, skin and bone substitution, tendon, ligament, and nerve replacement. In this report we demonstrate two uses of collagen. First as a fiber to support fibroblast growth in vitro, and second as a demineralized bone/collagen sponge for radial bone defect repair in vivo.For the in vitro study, collagen fibers were prepared as described previously. Primary rat tendon fibroblasts (1° RTF) were isolated and cultured for 5 days on 1 X 15 mm sterile cover slips. Six to seven collagen fibers, were glued parallel to each other onto a circular cover slip (D=18mm) and the 1 X 15mm cover slip populated with 1° RTF was placed at the center perpendicular to the collagen fibers. Fibroblast migration from the 1 x 15mm cover slip onto and along the collagen fibers was measured daily using a phase contrast microscope (Olympus CK-2) with a calibrated eyepiece. Migratory rates for fibroblasts were determined from 36 fibers over 4 days.

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